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مناظر احسن گیلانی

مولانا مناظر احسن گیلانی
حضرت الاستاذ رحمۃ اﷲ علیہ کا حادثہ وفات ابھی فراموش نہ ہوا تھا کہ آسمان علم و ادب کا ایک اور آفتاب غروب ہوگیا اور مولانا مناظر احسن گیلانی نے ۵؍ جون ۱۹۵۶؁ء کو انتقال کیا، وہ اپنے اوصاف و کمالات میں علمائے سلف کی یادگار اور علوم کی جامعیت، ذہانت و ذکاوت، دین و تقویٰ اور اخلاق و سیرت میں اس دور میں یگانہ تھے، جو اسلامی علوم میں ان کی نگاہ نہایت وسیع اور اس کی ہر شاخ میں ان کے قلم و زبان کی روانی یکساں تھی، اپنی ذہانت و اطباعی سے ایسے ایسے گوشوں سے معلومات و مسائل کا استنباط اور معمولی معمولی باتوں میں ایسے ایسے لطائف و نکات پیدا کرتے تھے کہ حیرت ہوتی تھی، علم ان کے تابع تھا وہ علم کے تابع نہ تھے ان کی ذہانت کتابوں کے انبار سے بے نیاز تھی، وہ تھوڑے معلومات سے ایسے مطول مضامین اور ضخیم کتابیں لکھ دیتے تھے جس کے لیے دوسرے مصنفین کو بڑے بڑے کتب خانوں کی ضرورت ہوتی ہے، ان کا نکتہ آفریں دماغ اور موّاج قلم جدھر رخ کردیتاتھا، تحریر کا دریا بہادیتا تھا، اور اپنے زور میں لعل و جواہر اور خس و خاشاک سب کو بہالے جاتا تھا۔
وہ ایک عرصہ تک جامعہ عثمانیہ کے شعبۂ دینیات کے صدر رہے، اور چوتھائی صدی سے زیادہ، ان کا علمی و تعلیمی فیض جاری رہا، اس زمانہ میں انھوں نے اپنے تلامذہ سے جو علمی و تحقیقی مقالات لکھوائے وہ اسلامی علوم کو جدید رنگ میں پیش کرنے کا ایک نمونہ ہیں، اس کے ذریعہ انھوں نے اس موضوع پر کام کرنے والوں کے لئے ایک شاہراہ قائم کردی۔
جامعہ عثمانیہ کے طلبہ میں اسلامی علوم پر تحقیقات اور جدید علوم سے ان کے موازنہ کا جو ذوق پیدا ہوا، اس...

Endoscopic Versus Open Radial Artery Harvesting Used in Coronary Artery Bypass Grafting, Our Experience at Queen Alia Heart Institute Endoscopic versus open radial artery harvesting used in coronary artery

Coronary artery stenosis bypass by using radial artery is good techniques which have longer outcomes. In coronary artery bypass grafting (CABG) the radial artery has several advantages. The radial artery has a thick muscular wall which is more susceptibleto contraction from the competitive flow. As compared to the open harvesting technique endoscopic harvest of the radial artery has long lasting cosmetic results it also reduces the post-operative complications. The purpose of the study is to compare the two harvesting techniques and compare the short term and long term results related to intra-operative and post-operative outcomes Methods: This is retrospective study (In Queen Alia Heart Institute, Amman, Jordan) to compare endoscopic radial artery technique versus open technique by reviewing patients files through a period between June 2013 and June 2018. Total 50 patients of CABG surgery was selected they were divided into two groups. Group A includes endoscopic radial harvest (n= 10) and Group B includes open harvest (n=40). Data was collected on predesigned Performa. Data were entered and analyze through IBM SPSS 22.0 Results: There was insignificant dissimilarity between the pre-operative outcomes between groups. The Post-operative outcomes were almost same in both groups except hand numbness (P-value<0.005). The comparison of intraoperative outcomes like harvest time between both groups indicate that the mean harvest time in group A was shorter than group B (39.20 + 3.73 Vs 51.90 + 2.09, P-value=0.000). The operative time in group A was higher than the group B (306.0 + 11.6 Vs 278 + 4.25 p-value=0.00). The hospital stays in both groups were insignificantly different (p = 0.09) Conclusions: Endoscopic radial artery harvest is best suited technique for CABG surgery as it significantly decreases the harvest time as well as hospital stay. It is also proven that it is safer, less painful and better wound appearance technique with exceptional outcomes based on positive surgical experience.

Assessment of Anti-Proliferative and Anti-Inflammatory Potential of Thymoqunione Tq and Thymohydroquinone Thq Coupled With Poly Lactide-Co-Glycolide Nanoparticles

Current study was designed to extract phytochemical compounds, thymoquinone (TQ) and thymohydroquinone (THQ) from indigenous herbs i.e., Nigella sativa (seeds) and Thymus vulgaris (aerial parts). Extracted compounds were further subjected to evaluate their anti-proliferative and anti-inflammatory activities and loaded in novel biodegradable drug carrier system including pectin and poly lactide-co-glycolide (PLGA) to achieve a controlled drug release system. Drug carrier system was synthesized by extracting pectin from waste peels of citrus fruits (lemon, orange and grape fruit). To enhance the stability, FDA approved PLGA drug carrier was physically cross-linked with pectin hydrogel. This may potentially introduce an opportunity to utilize organic waste in pharmacology.Results showed that soxhlet extraction at ratio of n-hexane: methanol (1:4) has been the appropriate combination to extract maximum yield of TQ from N. sativa (56.13%) and T. vulgaris (22%). THQ extraction was not achievable due to its very less stability. HPLC quantification of essentials oil of N. sativa showed higher amount of TQ i.e., 368.55±0.12 mg/kg (Mean±SEM) and T. vulgaris had 197.58±0.7 mg/kg. The pectin was successfully extracted in maximum yield from waste peels of lemon as compared to other two samples i.e., 35.3±0.66 g (Mean±SEM). Characterization of pectin extracted from each samples showed orange pectin potentially more suitable for hydrogel formation. SEM analysis confirmed the nanoparticles of TQ efficaciously produced loaded in PLGA-PEG at average size of 280 nm. TQ has been proved to be potent anti-proliferative and anti-inflammatory agent by in-vivo antioxidant assays (DPPH and FRAP assay), MTT assay against HeLa cancer cell line and SRB assay against HCT116 colon cancer cell line. Inhibition concentration (IC50) of TQ against HeLa and HCT116 cancer cell lines showed less significant difference (p > 0.05) to the IC50 of control commercial anti-cancer drug (cisplatin). TQ and its nanoparticles loaded in pectin hydrogel showed delayed release of TQ thus enabling the controlled drug release from 24 to 72 hours. TQ thus obtained can be utilized against early treatments of variety of cancers as can be observed from IC50 obtained against HeLa and HCT116 cancer cell lines. Findings of the current study indicate the potential of local resources in effectiveness against cancer. Therefore, increased incidences of cancer can be reduced among impoverished areas.
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