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ڈاکٹر محمد حمیداﷲ

آہ! فاضل گرامی ڈاکٹر محمد حمیداﷲ رحلت فرما گئے
افسوس صد افسوس کہ وہ فرزند اسلام نہیں رہا، جس کی اذانِ توحید سے مغرب کی وادیاں گونج رہی تھیں اور ہزاروں نفوس ایمان و اسلام کی دولت سے بہرہ ور ہورہے تھے، وہ سرچشمہ ہدایت بند ہوگیا جس سے مریضانِ کفر و ضلالت شفایاب ہورہے تھے، واحسرتاکہ دین و دانش کا وہ آفتاب غروب ہوگیا جس سے مشرق و مغرب دونوں ضیابار تھے اور تاریکیوں میں بھٹکنے والے راہ یاب ہورہے تھے، علم کا وہ بے کراں سمندر راکد ہوگیا جس سے اسلام کا درخت سرسبز و شاداب تھا، دریاے تحقیق کا وہ شناور اور غواص چلا گیا جو یورپ کے کتب خانوں میں اپنے آبا کی موجود کتابوں سے علم کے جواہر نکالتا تھا، وہ پیکرِ علم و فن روپوش ہوگیا جو ابرنیساں بن کر پون صدی سے موتی لٹارہا تھا، حکمت و معرفت کا وہ مجمع البحرین دنیا سے رخصت ہوگیا جو مشرق کے علمی میخانوں سے بھی سرشار تھا اور مغرب کے میکدہ حکمت سے بھی مخمور تھا، وہ ہستی نہیں رہی جس کے فیض و کمال کا سکہ بلادِ مشرق اور عالمِ اسلام ہی میں نہیں، یورپ و امریکہ میں بھی چل رہا تھا، حیف صدحیف اس ذات گرامی کا خاتمہ ہوگیا جس کا دماغ نادر معلومات کا خزینہ اور سینہ علومِ نبوی کا سفینہ تھا، جس کا قلم دشمنانِ اسلام کی علمی خیانتوں اور عیاریوں کو بے نقاب کرتا تھا اور اسلام اور اسلامی تعلیمات کی حقانیت و صداقت کو آشکار کرتا تھا، آہ ثم آہ کہ وہ سراپا علم و تحقیق روپوش ہوگیا جو تاریخ اسلام اور سیرت نبوی کے اولین مصادر اور مسلمانوں کے نایاب اور گم شدہ علمی اندوختوں کو ڈھونڈ نکالتا تھا، وہ وجودِ مقدس خاموش ہوگیا جس نے پیرس میں بھی آداب سحر خیزی نہیں چھوڑے، جس...

Analysis of Factors that Influence Purchasing Decisions for Wardah Cosmetics in Pekanbaru City

The objective of this study was to identify the factors that influence consumers' decisions to purchase Wardah cosmetics in Pekanbaru city. The sample size consisted of 100 participants selected using the accidental sampling technique. This study aimed to be unbiased, clear, and concise, utilizing a formal register and precise language to ensure comprehension. The data analysis employed quantitative multiple linear regression, and the data were analyzed using the SPSS software. Based on the results of this study, it is evident that product quality has an impact on the decision to purchase Wardah cosmetics in the city of Pekanbaru. The customer's perception of prices also affects their decision to purchase the said cosmetics, as well as promotions.  The independent variables, namely product quality, price perception, and promotion, have a significant impact on the dependent variable, i.e., purchasing decision, concerning Wardah Cosmetics in Pekanbaru city. The R Square value of 0.845 or 84.5% indicates that the purchasing decision is influenced by product quality, price, and promotion while 15.5% is attributable to other variables not considered in this study.

Genetic Studies of Cardiovascular Diseases

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the underdeveloped countries like Pakistan, leading to socioeconomic destabilization of the community. Among the different factors that play a role in the onset and progression of disease, raised plasma cholesterol levels is considered to be a major factor in the development of atherosclerosis, a typical character for the development of CVDs. Candidate gene screening of hypercholesterolemia families and sporadic individuals revealed two mutations in LDL-C binding domain (La) of LDLR (c.264G>C, p.R88S and c.887_889GCA>AGC, p.296*), four missense mutations in EGF like domain (c. 1019_1020delinsTG, p.C340L; c.1211C>T, p.T404I; c.1214 A>C, p.N405T; c.1634G>A, p.G545E and c.1916T>G, p.V639) and one premature terminating mutation (c.2416_2417 Ins G, p.V806GfsX11) in the transmembrane domain of LDLR. The La domain mutation has been shown to lead to inefficient binding of LDL-C with the receptor, while mutations in EGF like domain were found to cause decreased recycling of LDLR to the hepatocytes surface, which resulted in raised cholesterol levels in the patients. Two variants in PCSK9 i.e., c.314G>A, p.R105Q and c.464C>T, p.P155L, were also found in two different families with a history of CABG. The variant c.314G>A, p.R105Q resulted in 19% decrease in LDL-C levels in heterozygote carriers compared to homozygote normal individuals predicting it to be a “loss of function mutation”, while the second variant c.464C>T, p.P155L was located in the autocatalytic site of PCSK9 which may impact on LDL-C, but its exact effect could not be determined due to the small family size. In case control studies on MI cases in Pakistani population, the screening of selected panel of single nucleotide polymorphisms (SNPs) within five different genes was conducted. It was found that rs1333049 (ANRIL) was significantly associated with the onset of disease (p<0.001), while rs10920501 (FAM5C), rs1042579 (THBD), rs4646994 (ACE) and Intron 4 VNTR (eNOS) were not associated with the onset of MI (p>0.05). The stratification of data based on coronary artery disease (CAD) family history revealed significant association of the risk allele in ACE and eNOS polymorphisms with OR 1.83(95% CI=1.06-3.14) and 1.82(95% CI=1.03-3.22), respectively. This also indicates that the clustering of genetic factors within the ixfamilies are responsible for the onset of MI in Pakistani families. The relationship of rs1333049 risk allele “C” with phenotype impact on the lipid profile also showed a marked decrease in total cholesterol in individual homozygous for risk allele, which was observed in an independent cohort of hypercholesterolemia patients from the affected families as compared to their normolipidemic individuals. From this study, it is revealed that the Pakistani population has genetic heterogeneity, which predisposes the individuals to an increased risk of MI.
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