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صدیق رضی اللہ تعالیٰ عنہ کے لیے ہے خدا کا رسول صلی اللہ علیہ و آلہٖ وسلم

’’صدیق کے لئے ہے خدا کا رسول بس‘‘
امت کے بہترین افراد کو نبیصلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کے نام سے یاد کیا جا تا ہے ، یہ ایسے نفوس قدسیہ ہیں جن کے پیشِ نظر نزول وحی ہوتا ہے۔ جن کی نظر یں جلوۂ نبوت کا طواف کرتی ہیں۔ جن کے کانوں سے زبانِ مصطفیٰ صلی اللہ علیہ و آلہٖ وسلمسے نکلنے والے الفاظ معانقہ کرتے ہیں، جن کی کفِ پانقش نعلینِ مصطفی صلی اللہ علیہ و آلہٖ وسلمکی تلاش میں سر گرداں رہتی ہیں، جن کے شب وروز معجزات نبی صلی اللہ علیہ و آلہٖ وسلم کا مشاہدہ کرتے رہتے ہیں، نبی صلی اللہ علیہ و آلہٖ وسلمکی نظر یں جن کی تربیّت کرتی ہیں، جن کی آنکھوں میں نبوت سراپا، قلوب و اذہان میں نبی صلی اللہ علیہ و آلہٖ وسلمکی سوچ اور تعمیر میں نبی صلی اللہ علیہ و آلہٖ وسلم کا کردار پیش نظر ہوتا ہے۔
جس طرح جملہ انبیاء کرام علیہ السلام میں گنبدِخضریٰ کے مکین کا کوئی ثانی نہیں ہے۔ اسی طرح آپ صلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کی بھی مثال دیگر انبیاء علیہ السلام کے صحابہ سے نہیں ملتی۔ حضور صلی اللہ علیہ و آلہٖ وسلم کے تمام صحابہ کرام رضوان اللہ تعالیٰ اجمعین آپ صلی اللہ علیہ و آلہٖ وسلم کے جانثار تھے لیکن جانثاری کی جو مثالیں صدیقِ اکبر ثنے قائم کیں۔ تاریخ کے اوراق ایسی مثال سے قاصر ہیں۔ تاریخِ اسلام کا مؤرخ ایسی مثال پیش کرنے سے قاصر ہے، تاریخِ عالم رقم کرنے والے جملہ مؤرخین ایک عظیم محبت اور جانثاری کی مثال دینے کیلئے اپنے لبوں کو اور اپنے قلم کوجنبش دینے میں بے بس نظر آتے ہیں۔ سیدنا صدیقِ اکبر ص کا اوڑھنا بچھونا سنت ِمصطفی صلی اللہ علیہ...

إنهاض المجتمع و تنوير العقل دراسة في روايات طه حسين و نذير أحمد

Egyptian society and Indian society faced many social issues, especially during the British colonial rule in the nineteenth and twentieth centuries. The British occupation was an era of decline for the Muslims of the sub-continent. Public minds were not able to recognize this change and did not fully understand the requirements of the time. Writers and poets of that time discussed and dealt with social isues and tried to raise the almost dead community back to life. They wanted their people to be rationalized and to understand the problems of society. Two of those leading writers were Taha Hussein and Deputy Nazir Ahmed.             This article will examine Taha Hussein’s role and contribution in raising of Egyptian society and enlightening the Arab minds and also throw light on the efforts of Deputy Nazir Ahmed, a leading social novelist in the sub-continent. The most important issues that were treated through their novels and their writings were the problems and issues of woman and the issue of moral decline in society.

Mutation Spectrum in Pakistani Patients With Inherited Metabolic Disorders

Inherited metabolic disorders constitute a diverse class of genetic diseases caused by impairment in biochemical processes because of defective enzymes or transporters consequent upon which compromised conversion of substrate into the product takes place. These disorders are manifested phenotypically with a wide overlapping spectrum of signs and symptoms that could either be due to accumulation of toxic upstream substrates, insufficient production of downstream products or abnormal alternative substrate metabolism. Biochemical and molecular investigations help in diagnosis of hereditary metabolic disorders and that if attempted early, could improve therapeutic outcome in some cases. The current study was performed to investigate the spectrum of genetic variants in Pakistani patients with inherited metabolic disorders. A cohort of sixty-eight patients was enrolled in the study from local hospitals. Twenty-five of these patients were diagnosed with inherited unconjugated hyperbilirubinemias, one with GM1 gangliosidosis, nineteen with various types of mucopolysaccharidoses (MPS), and twenty-three with Wilson’s disease. Genomic DNA samples of these patients were subjected to Sanger sequencing of respective genes. The identified variants were confirmed in families of the patients for segregation. Sequence analysis of UGT1A1 in twenty-five patients diagnosed with inherited unconjugated hyperbilirubinemias identified 16 different variants, six of which were novel. The c.622-625dupCAGC and c.1021C>T were the most frequently observed UGT1A1 variants. DNA sequencing of GLB1 in one patient diagnosed with GM1 gangliosidosis identified a novel homozygous 2-bp deletion c.881-882delAT (p.Tyr294Terfs) in exon 8. Among nineteen patients diagnosed with various types of mucopolysaccharidoses during the study period, MPS type I was the most prevalent phenotype. DNA sequencing of IDUA in MPS type I patients revealed a diverse spectrum of variants spanning the whole gene. A missense variant c.1469T>C (p.Leu490Pro) was the most common variant identified in five patients in homozygous condition. Mutations identified in other MPS types were all private mutations and include c.1006+1G>C, c.1165C>T in IDS, c.531+5G>A in NAGLU, c.902G>A, c.1175C>T, c.IVS4-1G>A in GALNS and c.511-512delGG in ARSB. DNA sequencing in a cohort of twenty-three Wilson’s disease patients identified a diverse spectrum of 18 ATP7B variants spanning over the whole gene. The mutation detection rate was 71.7% and seven of the identified variants were novel. The most frequently observed ATP7B variant was c.3809A>G followed by c.3182G>A. To our knowledge, this is the first comprehensive study of inherited metabolic disorders from Pakistan. It should be helpful in neonatal screening, improved genetic counseling, and prenatal diagnosis in the affected families.
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