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Home > Synthesis and Characterization of New Sulfonamides of Triazoles As Potential Biological Agents

Synthesis and Characterization of New Sulfonamides of Triazoles As Potential Biological Agents

Thesis Info

Author

Mahmood-Ul-Hassan Khan

Department

Deptt. of Chemistry, QAU.

Program

Mphil

Institute

Quaid-i-Azam University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2005

Thesis Completion Status

Completed

Page

57

Subject

Chemistry

Language

English

Other

Call No: DISS/M.Phil CHE/625

Added

2021-02-17 19:49:13

Modified

2023-02-19 12:33:56

ARI ID

1676716788341

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غلام محمد (گورنر جنرل پاکستان)

غلام محمد صاحب (گورنر جنرل پاکستان)
افسوس ہے کہ غلام محمد صاحب گورنر جنرل پاکستان نے ایک طویل علالت کے بعد انتقال کیا، وہ نہ صرف اپنے عہدوں بلکہ دل و دماغ کے لحاظ سے بھی اس دور کے نامور لوگوں میں تھے، خصوصاً مالیات کے بڑے ماہر تھے، ایک زمانہ میں حکومت ہند اور ریاست حیدرآباد میں فنانس کے بڑے بڑے عہدوں پر ممتاز رہے تھے اور ہر جگہ اپنی مہارت فن کا ثبوت دیا، پاکستان کی گورنر جنرلی کے زمانہ میں ان کی سیاسی اور دماغی قابلیتیں نمایاں ہوئیں، چنانچہ انھوں نے بڑے نازک موقعوں پر پاکستان کی حکومت کو اپنی ہوشمندی اور قوت سے خطرات سے بچایا اور اس کے استحکام کی کوشش کی، گو ان کے بعض اقدام آمرانہ تھے، لیکن پاکستان جیسے ڈاواں ڈول سیاست والے ملک کے لیے ایسے ہی مضبوط لیڈر بلکہ ایک اچھے ڈکٹیٹر کی ضرورت ہے، اس کے بغیر اس کو استحکام نہیں ہوسکتا۔
ان کی قابلیتوں کے ساتھ ان کی ذات مختلف حیثیتوں سے بڑی غنیمت تھی، وہ پنجابی تھے لیکن ان کی تعلیم علی گڑھ میں ہوئی تھی، پھر ملازمت کے سلسلہ میں عرصہ تک دلی اور لکھنو میں رہے، اس لیے اس صوبہ کے لوگوں سے ان کے بڑے تعلقات تھے، پنڈت جواہر لال نہرو بھی ان کے دوستوں میں تھے، اس لیے قدرۃً اس کا اثر دونوں ملکوں کی سیاست پر بھی پڑتا تھا، چنانچہ غلام محمد صاحب مرحوم کی گورنر جنرلی کے زمانہ میں دونوں ملک ایک دوسرے کے بہت قریب آگئے تھے، جس کی توقع نئے اور اجنبی لوگوں سے نہیں ہوسکتی، مذہبی حیثیت سے راسخ العقیدہ بلکہ خوش عقیدہ مسلمان تھے، حج و زیارت سے بھی مشرف ہوئے تھے، حاجی وارث علی قدس سرہ سے ان کو بڑی عقیدت تھی، چنانچہ اپنی گورنر جنرلی کے زمانہ میں وہ ان کے مزار...

بدائع التفاسیرکی روشنی میں سماجی حسد سے بچنے کے تدابیر کا تحقیقی مطالعہ

Like all the physical diseases, which are fatal for a body, all the ethical weaknesses, like avarice, rampage, and malignity are also most harmful for a man. But, amidst these, envy is the malady which, apart from personally, also affects badly the whole society. Individually, the victim of envy suffers from a high psychological troubles and inner becomes subjected to many diseases. The reaction of envy firstly attacks the envier, rather than the envied person. There can never come affection or consolidation in the society which contains this moral disease: envy. That is why, the Holy Qur┐’n directs us to seek refuge from the envy of an envier. The Holy Qur┐’n says : ( Say, I seek refuge) from the evil of an envier when he envies. The Holy Prophet said: Avoid yourselves from envy, it eats one’s good deeds such as a fire eats the wood.

Development, Modification and Applications of Polymeric Substances for Biomolecules in Separation Science

The availability of stationary phases for crude and specific separations is an important task achieved by a separation chemist. This necessity becomes vital when the complex samples like biofluids are to be dealt with proteome science. The emergence of new synthetic polymers has a massive and continuing effect on the direction and capabilities of modern analytical science. The derivatization of these polymers has made them an efficient class of substrate, having unique properties and the selectivity tailored surface chemistries for target molecules. The deeper and detailed characterization of complex sample types has become feasible due to the enhanced selectivity and sensitivity offered by these polymer materials. The work presented here involves the synthesis and application of a terpolymeric sorbent and two bi-functional polymers with different functionalizations adapted for the selective enrichment of biomolecules of interest from biological fluids. Also a polymeric monolith is prepared and modified by controlled growth of porous coordination network to enable it for the selective enrichment for biologically relevant phosphopeptides. Each of bifunctional monomers, glycidyl propargyl ether (GPE) and allylglycidyl ether (AGE) is thermally polymerized with divinylbenzene (DVB) to form poly(GPE/DVB) and poly(AGE/DVB). Synthesis of terpolymer is carried out by the radical polymerization of monomers; methyl acrylate, acrylic acid and vinyl acetate with diethylene glycol dimethacrylate as cross-linking agent benzoyl peroxide as initiator. Synthesized polymers are characterized by scanning electron microscopy (SEM), energy dispersive X-Ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR). The polymers are further derivatized to IMAC (immobilized metal ion affinity chromatography) and are investigated by loading different metal ions (Fe3+, Ti4+, Zr4+ and La3+). The trypsin digested products of phosphoproteins, such as casein, non-fat milk, egg yolk, HeLa cell extract and human blood serum, are used to explore phosphopeptide enrichment ability of the modified polymers from complex samples. Serum profiling of healthy and diseased samples demonstrates the potential of new polymer to impart in the disease diagnosis. The identification with their sequence coverage is made using mascot and Phosphosite Plus. Poly(AGE/DVB) has high selectivity of 1:2000 with BSA background. Hydrophobicity is introduced to the polymers through octadecyl amine (ODA) which provides compatible results to commercially available reverse phase materials for the desalting of complex mixtures of all caseins. In another approach, an iron-benzenetricarboxylate (FeBTC) coordination network has been confined within the pores of a polystyrene-divinyl benzene-methacrylic acid polymer monolith by means of a step-by-step in-situ growth mechanism. The enhanced amount of active metal sites due to the gradual incorporation of Fe(III) through coordination with trimesic acid enables the selective enrichment of biologically relevant phosphopeptides. The FeBTC-porous polymer monolith preparation is adapted to a capillary column format, obtaining for the first time, a flow- through miniaturized device containing a porous coordination polymer thin layer, which is implementable for the efficient purification of biological samples.