Search or add a thesis

Advanced Search (Beta)
Home > Combined Impact of Islamic Work Ethics and Supportive Organizational Culture on Organizational Citizenship Behavior, Knowledge Sharing Behavior, and Creative Performance

Combined Impact of Islamic Work Ethics and Supportive Organizational Culture on Organizational Citizenship Behavior, Knowledge Sharing Behavior, and Creative Performance

Thesis Info

Author

Riaz, Muhammad

Supervisor

Khurram Shahzad

Institute

Riphah International University

Institute Type

Private

City

Islamabad

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Page

xiv, 88 . : ill. ; 30 cm. +CD

Subject

Management & Auxiliary Services

Language

English

Other

Includes bibliographical references;; English; Call No: 658.3044 RIA

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676711880934

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

عشق دا کریے جدوں آغاز

عشق دا کریے جدوں آغاز
راز نوں رکھیے راز ہی راز
جیہڑا رزق حلال کماوے
ہے اقبال دا اوہ شہباز
دل وچ رکھ کے یاد سجن
سمجھو ایہو خاص نماز
راہاں وچ چھڈیں نہ دلبر
ایہو ساڈا عجز نیاز
اساں تاں پھردے دھرتی اُتیّ
سجناں دی اچی پرواز
دل نہ بدلے جس تھیں کجھ
کی کرنا اوہ سن کے ساز
کوٹھے تے چڑھ دیواں ہوکا
عشق توں رہنا سجنو باز
پاک نبیؐ سرور تے ہر دم
پڑھ دے رہیے سلام نماز

پاکستانی معاشرہ اور تعلیمات قرآنی میں بعد

In spite of the fact that Pakistan is an Islamic Republic, 97% of the population is Muslim and majority of it is considered sentimently staunch Muslims; it is a fact that society is not familiar and closely attached with Quranic injunctions. There are many reasons for that such as custom of teaching Quran Nazira (reciting Quran without understanding), Arabic language is not part of curriculum and when it is taught in DiniMadaris, it is taught in boring Grammar Method relying on memorization. Quran is not taught in modern schools, colleges and universities and lower social status of Quran teachers etc. It is absolutely necessary that teaching Quran with comprehension and understanding is given due importance by Ulama, governments and Muslim society at large. It should be made integral part of curriculum in modern schools and universities. Status of Quran/Arabic teachers should be elevated and Arabic language should be taught in an attractive method;  and other necessary measures are taken to make Quran ‘talk of the town’ so that every Muslim understands it and acts upon its injunctions.

Synthesis of Some N4-Substituted Isatins-3-Thiosemicarbazones and Their Transition Metal Complexes As Potential Bioactive Agents.

The focus of this thesis is on the synthesis and in vitro biological testing of some target N4- substituted isatin-3-thiosemicarbazones and their transition metal complexes. Thus, three series of N4-benzyl substituted isatin-3-thiosemicarbazones (19-33), (34- 48) and (49-63) were synthesized by condensing isatin, 5-nitroisatin and 5-chloroisatin, respectively, with the appropriate N-substituted thiosemicarbazides. All the synthesized thiosemicarbazones (19-63) were characterized by means of their analytical (CHN) and spectral (IR, 1H-NMR, 13C-NMR, EIMS) data and tested for the selected biological properties i.e. antiurease, phytotoxic, cytotoxic, anticarbonic anhydrase and antiglycation activities. All the synthetic thiosemicarbazones (19-63) proved to be highly potent inhibitors of urease, displaying excellent inhibitory activity (IC50 = 0.87 ± 0.25 − 11.23 ± 0.19 µM) even better than the reference inhibitor, thiourea (IC50 = 22.3 ± 1.06 µM) used in the assay. In phytotoxicity assay, 33 out of 45 thiosemicarbazones tested i.e. (19-22), (25), (26), (28-30), (32), (33), (34-40), (42-44), (46-48), (51), (52), (56-61) and (63) appeared to be active, exhibiting weak or non-significant (5-100%) growth inhibition of Lemna aequinocitalis at 1000 or 500 µg/mL concentrations in comparison to paraquat (the standard herbicide), which showed 100% plant growth inhibition at 0.015 µg/mL concentration. In the brine shrimp (Artemia salina) lethality bioassay, only 4 compounds i.e. (20), (28), (33) and (42) were found to be active, demonstrating cytotoxic activity with LD50 values 3.63 × 10-5, 2.90 × 10-5, 2.31 × 10-4 and 2.55 × 10-5 M, respectively. The remaining compounds gave LD50 values greater than 2.36 × 10-4 − 3.22 × 10-4 M and were, therefore, considered to be almost inactive. On the other hand, in the carbonic anhydrase (CA-II) inhibition bioassay, all the trial compounds (19-63) showed less than 50% of enzymatic inhibition and thus were considered to be inactive. However, in the antiglycation activity assay, 21 out of 45 compounds tested i.e. (20-22), (24), (26), (28), (29), (34), (36), (39), (45), (47), (48), (50), (51), (56-59), (61) and (62) proved to be potent inhibitors of glycation, demonstrating inhibition with IC50 values ranging from 114.51 ± 1.08 to 643.80 ± 5.80 µM. Of these, (21), (22), (26), (28), (29), (34), (36), (51), (56-58) and (62) exhibited superb inhibitory activity (IC50 = 114.51 ± 1.08 – 241.90 ± 1.97 µM) even better than the reference inhibitor, rutin (294.50 ± 1.50 µM) and thus may act as convincing leads for further studies. The synthetic thiosemicarbazones (19), (21), (22), (24-31), (34-37), (39-42), (44-46) and (48) were used as ligands for synthesizing their Cu(II) complexes. All the synthesized metal complexes (64-86) were characterized by means of their analytical (CHN), spectral (IR, R (Raman), UV-Vis), magnetic moments, thermal and molar conductance data, and evaluated for the selected biological properties viz. antiurease, anticarbonic anhydrase and antiglycation activities. In antiurease assay, coordination of all the thiosemicarbazone ligands to metal ions was found to lead to decrement in the enzyme inhibitory activity that they possessed. Relatively, extensive decrease occurred in the cases of (65), (67), (68), (71), (73), (76-81) and (84). On the contrary, in CA inhibition bioassay, coordination of the ligands to metal ions was found to give rise to induction of enzyme inhibitory activity in certain cases. For example, the metal complexes (66), (72-76), (80) and (83-86) exhibited promising enzymatic inhibition with IC50 values 5.9 ± 0.00 − 21.26 ± 0.35 µM in contrast to the corresponding ligands (22), (29-31), (34), (35), (40), (44-46) and (48), which displayed less than 50% (i.e. from − 9.3 to 33.1%) inhibition of the enzyme and thus considered to be inactive. Similarly, the coordination of thiosemicarbazone ligands to metal ions was found to bring about either induction or enhancement of antiglycation activity. For example, the metal complexes (64), (68), (70), (73), (74), (76), (78), (80-83) and (85) showed excellent activity with IC50 values ranging from 105.74 ± 3.1 to 247.06 ± 1.75 µM as compared to the relevant ligands (19), (25), (27), (30), (31), (35), (37), (40-43) and (46), which demonstrated less than 50% (i.e. 10.32−40.98 %) inhibition of glycation. Similarly, the metal complexes (65-67), (69), (71), (72), (75), (77), (79) and (84) displayed markedly enhanced antiglycation activity in comparison to the respective ligands (21), (22), (24), (26), (28), (29), (34), (36), (39) and (45) (IC50 values 94.64 ± 0.99 − 135.20 ± 1.87 vs. 209.87 ± 0.37 − 522.68 ± 9.1 µM).