Search or add a thesis

Advanced Search (Beta)
Home > سیرت النبیﷺاور مستشرقین کا علمی و تنقیدی جائزہ

سیرت النبیﷺاور مستشرقین کا علمی و تنقیدی جائزہ

Thesis Info

Author

دوست محمد خان

Supervisor

سعید اللہ قاضی

Department

شعبہ اسلامیات

Program

PhD

Institute

University of Peshawar

Institute Type

Public

City

Peshawar

Province

KPK

Country

Pakistan

Degree Starting Year

1994

Degree End Year

1995

Subject

Orientalism

Language

Urdu

Keywords

استشراق، سیرت
Orientalism,Sirah

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676709369442

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

مولانا عامر عثمانی

مولانا عامر عثمانی
افسوس ہے پچھلے دنوں مولانا عامر عثمانی ایڈیٹر تجلی دیوبند کابھی غریب الوطنی میں قلب کادورہ پڑنے سے اچانک انتقال ہوگیا، مولانا مفتی عتیق الرحمن صاحب عثمانی کے برادرعم زاد تھے، دارالعلوم دیوبند سے فراغت پائی تھی، ذہانت و طباعی اورشعرو ادب کا ذوق اس خاندان کی خصوصیت ہے۔ مرحوم کوبھی اس سے بہرۂ وافر ملا تھا۔چنانچہ اردو زبان کے نغزگوشاعر بھی تھے اورایک صاحب طرزادیب بھی،شگفتہ نگاری کے ساتھ قلم بے حد شوخ اوربے باک تھا۔تنقید میں لگی لپٹی کچھ اٹھا کے نہیں رکھتے تھے اوراس اعتبار سے اس شعر کامصداق تھے:
ناوک نے تیرے صید نہ چھوڑا زمانہ میں
تڑپے ہے مرغ قبلہ نما آشیانہ میں
لیکن تنقید بڑی محنت اورکثیر مطالعہ کے بعدکرتے تھے، مذہبیات میں طنز نگاری ان کی ایجاد تھی۔ اﷲ تعالیٰ کمزوریوں سے عفوودرگزر فرما کرمغفرت وبخشش کی نعمتوں سے سرفراز فرمائے۔آمین [مئی۱۹۷۵ء]

Efficacy, Safety and Tolerability of Valsartan and Hydrochlorothiazide Compared to Valsartan and Amlodipine in Stage 2 Hypertension

Background: Hypertension is a growing medical and public health issue. The United States and European treatment guidelines have been issued to attain smooth control of hypertension in various categories of patients. It is a need of time to unveil safe combination therapies in various populations. Objectives: (i) To determine the efficacy of valsartan and hydrochlorothiazide versus valsartan and amlodipine (ii) To determine the safety and tolerability of both combinations. Materials & Methods: This experimental study was conducted at Shalamar Hospital Lahore. 126 patients with stage 2 hypertension were recruited from the medical outdoor of Shalamar Hospital Lahore after getting informed consent. In group A, 63 patients were given valsartan and hydrochlorothiazide. In group B, 63 patients were given valsartan and amlodipine. Blood pressure (BP) of both study groups was recorded on day zero, 2nd, 4th, and 8th weeks and the readings were entered on a Proforma. The efficacy of drug combinations was accessed in both groups by recording the change in mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP). The safety and tolerability of the drug combinations were assessed in terms of side effects and laboratory findings. Results: In group A, there was a 39±7mmzHg and 18±1mmHg decrease in MSBP and MDBP, respectively, from baseline BP. In group B, there was a 26.7±4mmHg and 14±2 mmHg decrease in MSBP and MDBP, respectively, from baseline BP. Both combinations were safe, and no significant difference in the efficacy of both combinations was observed after 8-week of treatment. Conclusion: Both combinations are effective for control of BP, but the valsartan and hydrochlorothiazide combination (group A) appears to have better tolerability and greater effect in decreasing BP as compared to the combination of valsartan and amlodipine (group B), although this difference is not statistically significant.  

The Anti Diabetic Effect of Guaiacum Officinale in Streptozotocin Induced Male Albino Rats

Diabetes mellitus is a metabolic disorder and most common disease worldwide. In Asia more than 99% population suffered from type-2 diabetes. The occurrence and consequences of diabetes type 2 in children are also increasing with its complications. In the present study, the effect of Guaiacum officinale in streptozotocin induced diabetic rats in male albino rats was observed. For determining the anti-diabetic effect of bark extract of Guaiacum officinale, we developed type 2 diabetic rat model in albino rats by the use of streptozotocin at 30 mg /kg dose by intraperitoneal route. Initially OGTT was performed for the confirmation the development of type 2 diabetic model and the estimation of serum insulin by ELIZA technique. To determine the anti-diabetic activity of Guaiacum officinale, we selected male albino (Wistar) rats, weight 200±20 gms, acclimatized in uniform environment and conditions. Animals were divided in to four groups. Control group, streptozotocin induced diabetic group (positive control) Glibenclamide (Standard) group and Guaiacum officinale (treated) group. Streptozotocin administered at a dose 30 mg/ kg, I/P, single dose. Glibenclamide at 0.5 mg/kg dose by oral route for 28 days and Guaiacum officinale at 500mg/kg dose, orally for 28 days. After treatment of 28 days, we drawn blood samples by cardiac puncture technique for estimation of blood glucose, serum insulin, pancreatic enzymes, liver enzymes, bilirubin, kidney functions and electrolytes. Histo pathological studies were also performed by H&E staining and scanning electron microscopy. Animals were sacrificed by cervical decapitation, dissected and isolate the vital organs (pancreas, kidney and liver) to observe the histological changes in all 2 groups. Blood glucose was determined by glucometer and the data was analyzed by ANOVA SPSS version 20. Expressed in (Mean±SEM). The results of blood glucose level of treated group (G.O) showed highly significant results as compare to control group. The serum insulin level was performed by ELIZA rat kit. 144 animals were selected, results were expressed in (Mean± SEM) showed that the treated group found highly significant results equivalent to control group. The estimation of pancreatic enzymes (Amylase and Lipase) were performed, 144 male albino wistar strain weight 200±20 gms were selected, results were presented in (Mean±SEM) showed that the amylase level of treated (G.O) group was found highly significant and the level of pancreatic lipase of treated group was found highly significant. In the present study, determine the effect of Guaiacum officinale on liver enzymes, selected 144 albino rats, divided in to four groups, treated group treat with extract and standard group treated with Glibenclamide for 28 days. Blood was collected in a vacutainer containing gel tubes, centrifuged at 3000 rpm; serum was separated for estimation of liver enzymes. Data was analyzed by ANOVA SPSS version 20 and expressed in (Mean ± SEM). The results of serum Aspartate transaminase (AST/SGOT) showed that Guaiacum officinale (treated) group was found highly significant results as compare to control. The Gamma glutamyl transferase (γ- GT) level of treated albino rats with G. officinale for 28 days showed insignificant results were expressed in (Mean± SEM). The results of Alanine transaminase (ALT/SGPT) with compare to control, expressed in (Mean ± SEM) showed that the level of ALT/SGPT in treated albino rats was found insignificant. The alkaline phosphatase (ALP) of treated group (methanolic extract of Guaiacum officinale) at 500 mg /kg dose for 28 days by oral route. Results were expressed in (Mean±SEM) and compare with control, the treated group was found highly significant. The effect of G. officinale on bilirubin (Direct and indirect) was estimated in male albino Wistar rats, weight 200±20 gms, acclimatized under control conditions, divided in four groups. Treated group treated with (G. officinale) and standard group treated with GLB for 28 days. The results expressed in (Mean ± SEM) showed direct and indirect bilirubin was found insignificant.The effect of Guaiacum officinale was determined at 500 mg / kg dose on total lipids of male albino rats. The animals were treated with bark extract orally for 28 days. The level of cholesterol and triglycerides compare with control group expressed in (Mean ± SEM) was showed that the treated group (G. officinale) group was found to be highly significant. The level of triglycerides of male albino rats by the treatment with bark extract of G. officinale expressed in (Mean±SEM) showed significant results as compare to control.The effect of extract on high density lipoprotein (HDL) of albino rats estimated by ANOVA SPSS , expressed in (Mean± SEM) showed insignificant results with compare to control, while the results of low density lipoprotein (LDL) was showed highly significant and the value of VLDL showed insignificant result with compare to control. The effect of G. officinale at 500mg/kg dose on kidney functions (Urea and Creatinine) in male albino rats. The results were expressed in (Mean ± SEM) by ANOVA. The results of both urea and creatinine were found highly significant with respect to control.In present study, the effect of Guaiacum officinale on electrolytes (Sodium and Potassium) were observed in male albino rats at 500 mg/kg dose orally route for 28 days. Animals (144) were selected, weight 200±20 gms, divided in to four groups. Data expressed in (Mean± SEM) showed serum sodium of G. officinale treated group was found highly significant and serum potassium level was found to be insignificant with compare to control. The histo-pathological effects of Guaiacum officinale on tissues (pancreas, kidney and liver) of male albino rats were observed by H &E staining. The observations through microscopic examination proved that the bark extract of G. officinale showed highly significant with respect to control and supported by biochemical and hematological results. The histological studies of Guaiacum officinale on tissues (pancreas, liver and kidney) of male albino rats by scanning electron microscopy. The observations through electron microscope at different magnification showed that the bark extract of G. officinale protect the vital organs from diabetes and its disasters.