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Assembly Line Efficiency Improvement Using Value Stream Mapping [Bs Program] [+Cd]

Thesis Info

Author

Abbas Amin, Muhammad; Umair Bari, Muhammad

Supervisor

Abbas Raza

Department

University of Management and Technology

Program

BS

Institute

University of Management and Technology

Institute Type

Private

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Page

52 . CD

Subject

Manufacturing

Language

English

Other

Report presented in partial requirement for BS degree Advisor: Abbas Raza; EN; Call No: TP 670.42 ABB-A

Added

2021-02-17 19:49:13

Modified

2023-01-06 20:56:29

ARI ID

1676713268666

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کچھ مصنف کے بارے میں

کچھ مصنف کے بارے میں
بسم اللہ الرحمن الرحیم نحمدہٗ و نصلی علی رسولہِ الکریم
قانون ِقدرت ہے کہ جب دنیا میں صدق و حقیقت پر خواہش اور نفس پرستی کے غبار اور پردے پڑ جاتے ہیں تو اللہ تعالیٰ اپنے بندے پیدا کرتا ہے جو صدق و سچائی اور حقیقت کو دنیا میں روشن کر دیتے ہیں۔
ایسے ہی میرے تایا زاد حافظ محمد اکرم راشدؔ صاحب کو اللہ تعالیٰ نے گو نا گوں صفات سے نوازا ہے۔ عارف والا کے نواحی گائوں 37 ای بی میں 1962 کے اوائل میں علمی خانوادے میں آنکھ کھولی والدِ محترم حافظ اللہ یار رحمۃ اللہ علیہ عالم باعمل تھے ابتدائی تعلیم اُ ن سے حاصل کی ۔ پانچ سال کی عمر میں والدِ محترم داغِ مفارقت دے گئے ۔ اُس کے بعد حقیقی چچا میرے والدِ محترم حضرت علامہ حافظ شیر علی رحمتہ اللہ علیہ نے آغوشِ محبت میں لیا اور علم کی تکمیل تک ساتھ دیا ۔ میٹرک کر نے کے بعد علمی پیاس بجھانے کے لئے کراچی گئے وہاں علم کی پیاس بجھاتے ہوئے علم کے سمندر بن گئے ۔ فاضل درسِ نظامی ، فاضل طب وجراحت، فاضل عربی، فاضل اردو کرنے کے بعد پنجاب گورنمنٹ میں بطورِ مدرس تعینات ہوئے ۔ دورانِ سروس ایم ۔اے ایجوکیشن ،ایم اے اسلامیات اور ایم اے عربی (گولڈ میڈلسٹ) پاس کیا۔
علمی زندگی میں روزنامہ ایکسپریس ، نوائے وقت میں مضامین لکھے اور عوام کی کثیر تعداد نے مضامین کو پسند کیا۔تاحال عارفوالا کے نواحی گائو ں میں ہیڈ مدرس ہیں اور عارفوالا شہر میں بطورِ خطیب خدمات سر انجام دے رہے ہیں ۔ حافظ صاحب اپنے حلقہ احباب میں اپنی خوش اخلاقی اور بذلہ سنجی کی وجہ سے بہت مقبول ہیں ۔ اِن کی مذکورہ کتاب اُن کے علمی تبحّر کی گواہ ہے اللہ تعالیٰ اُن...

Exploring the Role of Female Successor “Amrah Bint Abd Al-Raḥmān” in Narration of Prophetic Traditions

Although several studies have investigated the contribution of Muslim women about their lives and works in large corpus of the ḥadīth sciences until now, but much are needed to be explored. Doubtlessly 'Amrah bint 'Abd al-Raḥmān had contributed to the large corpus of the ḥadīth sciences and also the core of Islamic knowledge parallel to her male counterparts. By highlighting her efforts for learning and her struggle for transmission of fundamental text, reveals how a female successor acquired exemplary reputations in her era. Particularly, her rich insight, deep knowledge in ḥadīth sciences and exemplary piety attracted students and placed parallel to her male counterparts in Islamic knowledge of her time. In sum, this study not merely sheds light upon the prolific contribution of an eminent female successor 'Amrah bint 'Abd al-Raḥmān in ḥadīth narrations, but argues that these scholarly females should be given more credit for being interacting educators and not just transmitters. Doubtlewssly, the study would be helpful to revise our understandings of Islamic knowledge during early period of Islam regarding gendered dynamics and their great contribution to dissemination and transmission of classical text and Islamic knowledge.

Synthesis, Structural Analysis and Pharmaceutical Screening of S-Substituted Derivatives of 1, 3, 4- Oxadiazole-2-Thiol and 1, 2, 4-Triazole-3-Thiol Having 4-Methylphenyl Sulfonyl Piperidine

Heterocyclic compounds are being focused by the organic and synthetic chemists because of their wide range of biological and other desirable applications. Five membered heterocyclic moieties, oxadiazoles and triazoles are among the most considered five membered heterocyclic cores for the production of new potential synthetic drugs. The most studied isomers of these heterocyclic moieties are 1,3,4- oxadiazole and 1,2,4-triazole owing to their potent pharmaceutical activities. Keeping in view the importance of 1,3,4-oxadiazole and 1,2,4-triazole heterocycles, a number of different S-substituted derivatives of 1,3,4-oxadiazole-2- thiol and 1,2,4-triazole-3-thiol having 4-methylphenyl sulfonyl piperidine have been synthesized and screened for the evaluation of pharmaceutical potential including antibacterial and enzyme inhibition. The antibacterial potential was evaluated against certain strains of Gram positive and Gram negative bacteria. Enzyme inhibition potential was evaluated against lipoxygenase (LOX) enzyme responsible for inflammation. The list of ninety seven (97) synthesized derivatives includes fifty seven (57) derivatives of 1,3,4-oxadiazole (7a-w, 11a-v, 14a-l) and forty (40) derivatives of 1,2,4-triazole (18a-t, 19a-t). The multistep protocols for all of these compounds have been described in five (5) schemes. The compound ethyl 1-tosylpiperidine-4- carboxylate (3) was synthesized by the reaction of 4-methylphenyl sulfonyl chloride (1) and ethyl isonipecotate (2) using 10% aqueous solution of Na2CO3 as reaction medium. The compound 3 was further converted into corresponding carbohydrazide (4) by hydrated hydrazine in methanol under reflux. 5-(1-(4-Methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5) was synthesized from compound (4) by reflux in ethanol in the presence of carbon disulfide (CS2) in basic medium. Twenty three (23) alkyl/aralkyl derivatives of 1,3,4-oxadiazole-2-thiol having 4-methylphenyl sulfonyl piperidine were synthesized (7a-w, Scheme-1) by the reaction of 5 and 6a-w. N-Substituted alkyl/aralkyl amines (8a-v) were made to react with 2-bromoacetyl bromide (9) to synthesize 2-bromo-N-substituted acetamides (10a-v) as electrophiles. The synthesized 1,3,4-oxadiazole-2-thiol (5) was further derivatized by these electrophiles (10a-v) to synthesize twenty two (22) N-substituted acetamide derivatives (11a-v, Scheme-2). N-substituted alkyl/aralkyl amines (8a-g,j,m,n,p,v) were made to react with 3-bromopropionyl bromide (12) to synthesize 3-bromo-Nsubstituted propanamides (13a-l). Again the synthesized 1,3,4-oxadiazole-2-thiol (5) was derivatized with these electrophiles (13a-l) to synthesize twelve (12) Nsubstituted propanamides (14a-l, Scheme-3). Compound 4 was refluxed with isothiocyanatobenzene (15) in methanol to produce N-phenyl-2-(1-4- methylphenylsulfonylpiperidine-4-carbonyl)hydrazine carbothioamide (16). The compound 16 was cyclized to 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3- thiol (17) using 10% aqueous solution of NaOH as reaction medium. The synthesized 1,2,4-triazole-3-thiol (17) was used to produce twenty (20) derivatives (18a-t, Scheme-4) on reaction with different alkyl/aralkyl halides (6a-t) in a polar aprotic medium. The synthesized electrophiles, 2-bromo-N-substituted acetamides (10a-s,u), were stirred with the synthesized 1,2,4-triazole-3-thiol (17) to yield twenty (20) different N-substituted acetamide derivatives (19a-t, Scheme-5). Structures of all the synthesized compounds were confirmed using Infra Red (IR) spectroscopy, Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR) spectroscopy and Electron Impact Mass Spectrometry (EIMS) data. Ring formation of 1,3,4-oxadiazole and 1,2,4-triazole was confirmed through 13C-NMR. The determined physical data of all the target compounds includes physical state, color, yield, melting point, molecular formula and molecular mass which are given in results section (Chapter-4). The synthesized compounds were screened for antimicrobial potential against Gram-positive and Gram-negative bacterial strains. The results of antibacterial potential are given as % inhibition and minimum inhibitory concentration (MIC) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 7a, 7c and 7m remained the most active against P. aeruginosa, S. aureus and E. coli respectively and compound 7o against both of S. typhi and B. subtilis. All of these (7a, 7c, 7m, 7o) showed antibacterial activity comparable to that of the reference standard, Ciprofloxacin. Among the acetamide derivatives (11a-v) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 11c and 11s exhibited proficient activity against S. typhi and P. aeruginosa, respectively and compound 11d against three strains including E. coli, S. aureus and B. subtilis. These three most active compounds also showed activity comparable to that of Ciprofloxacin. Among the propanamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl) piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), compounds 14b showed efficient activity against B. subtilis and P. aeruginosa; compounds 14d, 14f and 14g against E. coli, S. aureus and S. typhi, respectively and also comparable to that of Ciprofloxacin. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4- phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), compound 18a executed better potential against four bacterial strains S. typhi, E. coli, B. subtilis and P. aeruginosa and 18c against S. aureus. The observed potential was also comparable to the reference. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), the most active compounds were 19a against S. typhi, 19d against E. coli, 19o against B. subtilis and 19h against P. aeruginosa with MIC value close to that of the reference. Lipoxygenase (LOX) inhibition potential was evaluated with reference to Baicalein, the reference standard. The enzyme inhibition activity results are given as % inhibition and concentration for 50% inhibition (IC50) values. Among the alkyl/aralkyl S-substituted derivatives (7a-w) of 5-(1-(4-methyl phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 7a, 7b and 7c with reference of the standard, Baicalein. Among the acetamide derivatives (11a-v) of 5-(1-(4-methylphenylsulfonyl)piperidin- 4-yl)-1,3,4-oxadiazole-2-thiol (5), three the most potent inhibitors of LOX were 11m, 11n and 11t. Among the propionamide derivatives (14a-l) of 5-(1-(4- methylphenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (5), two the most potent inhibitors of LOX were 14e and 14f. Among the alkyl/aralkyl S-substituted derivatives (18a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (17), three the most potent inhibitors of LOX were 18a, 18b and 18c. Among the acetamide derivatives (19a-t) of 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole- 3-thiol (17), three the most potent inhibitors of LOX were 19g, 19n and 19r. The activity of all these compounds was compared to the reference, Baicalein. Furthermore, the molecular docking studies have been discussed in Chapter-4 for LOX inhibition activity. Overall a number of compounds exhibited moderate LOX inhibition potential as compared to reference standard, Baicalein. Many compounds showed excellent antibacterial potential. The most active compounds against bacterial strains might be suitable as new drug candidates in pharmaceutical industries to develop potent drugs for the different bacterial infection. The most active LOX inhibitors might be further forwarded as new drug candidates for inflammatory diseases.