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Design and Synthesis of 1, 24, Triazoles As Cytochrome P-450 Inhibitors

Thesis Info

Author

Zaheer Ahmad

Supervisor

Uzma Yunus

Institute

Allama Iqbal Open University

Institute Type

Public

City

Islamabad

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Page

xi, 103.

Subject

Chemistry

Language

English

Other

Call No: 547 ZAD; Publisher: Aiou

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676709859521

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مولانا سید محمد میاں

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افسوس ہے ہماری انجمن علم وعمل کی ایک اورشمع روشن بجھ گئی، یعنی مولانا سید محمد میاں نے مختصر علالت کے بعد۷۴برس کی عمر میں۲۲/اکتوبر کوعین مغرب کے وقت ارون ہسپتال میں داعی اجل کو لبیک کہااور راہی ملک بقا ہوگئے۔اناﷲ واناالیہ راجعون۔مولانا گوناگوں علمی وعملی کمالات کے جو ایک شخص میں شاذونادر ہی جمع ہوتے ہیں جامع تھے، ایک طرف وہ بلند پایہ عالم،فقیہ ومحدث تھے دوسری طرف جنگ حریت وآزادی کے نہایت بہادراور بے خوف سپاہی، ایک طرف مورخ ومحقق اورکثیر التصانیف مصنف اوردوسری جانب اعلیٰ دفتری تنظیمی صلاحیتوں کے مالک،ایک طرف عابد شب زندہ دار اوردوسری طرف نہایت متواضع اورخلیق وملنسار،بے لوث وبے غرض،نام ونمود سے دور،شہرت ووجاہت طلبی سے نفور،نرم دم گفتار اورگرم بوقت ِپیکار۔ مرحوم دیوبند کے سادات رضوی سے تعلق رکھتے تھے اس لیے دیوبند میں پیدا ہوئے اوروہیں ازاوّل تاآخر تعلیم حاصل کی۔ فراغت کے بعد بعض مقامات پرمدرس رہے مگر پھر جمعیت علماء سے وابستہ ہوئے تو اسی کے ہوکر رہ گئے۔ وہ مولانا حفظ الرحمن سیوہاریؒ کے دست راست تھے، اس سلسلے میں کئی مرتبہ جیل بھی گئے، باتیں کم کرتے تھے اورکام زیادہ، نہایت سمجھ بوجھ اورہوش وگوش کے انسان تھے اورنہایت چست اور مستعد۔ حقیقت یہ ہے کے دفتری نظم ونسق کا بھرم ان کے دم سے قائم تھا۔اگرچہ ایک عرصہ سے درس وتدریس کاباقاعدہ سلسلہ نہیں رہاتھا لیکن مطالعۂ کتب اور تصنیف وتالیف کاذوق فطری تھا اس بناپر جمعیت علماء کی ہنگامہ خیز اور شبانہ روز مصروفیات کے باوجود وہ پابندی سے اس میں بھی لگے رہے ،چنانچہ اسی زمانہ میں دوکتابیں ’علماء ہند کاشاندار ماضی‘(تین جلدوں میں)اور’ علماء حق‘(۲ جلدوں میں) ان کے قلم سے نکلیں اورشائع ہوتے ہی ارباب علم وذوق کے حلقوں میں مقبول و مشتہر ہوگئیں، مشرق ومغرب میں ان سے استفادہ کیا گیا اور ان دونوں...

The Challenge of Atheism and Its Solution in the Light of Islamic Teachings

This study critically examines the scientific, logical and civilizational aspects of the challenge of atheism and proposes how to combat this problem in the light of Islamic teachings. Twentieth century is peculiar in promoting atheism, agnosticism and skepticism. Contemporary modern scientific approach has also contributed towards the negation of the existence of God. Although our universe provokes our thoughts for the exploration of the ultimate reality yet most of us take it for granted and do not stare and care. Atheism is rapidly expanding trend in universities. Pakistani universities are not exception to it. This paper explains the scientific, logical, psychological, intuitive and spiritual arguments for the existence of God in the light of Islamic teachings.

Static and Dynamic Simulation of Heu and Leu Cores of Research Reactors Using Multi-Group and Coupled Space-Time Thermal Hydraulic Approach

Sadaf Waqar, PhD, Department of Physics & Applied Mathematics, PIEAS, June 2008." Static and Dynamic Simulation of HEU and LEU Cores of Research Reactors using Multi- group and Coupled Space-Time Thermal Hydraulic Approach”; Supervisor: Dr. Nasir M. Mirza; Co-Supervisor: Dr. Sikander M. Mirza; Department of Physics & Applied Mathematics, PIEAS, Nilore 45650, Islamabad. A comparative study has been performed for neutronic analysis of HEU and potential LEU cores for the Pakistan Research Reactor-2 (PARR-2) taken as a typical MNSR system. The group constant generation has been carried out using transport theory code WIMS-D4 and a detailed five-group RZ-model has been used in the CITATION code for multigroup diffusion theory analysis. The neutronic analysis of the 90% HEU (reference fuel) and potential LEU alternative fuels: UO2, U3Si2 and U9Mo, has been carried out yielding 11%, 20.7% and 14.25% enrichments with corresponding values of excess reactivity: 4.33, 4.30 and 4.07 mk. These results have been found in good agreement with recently reported Monte Carlo based transport theory calculations. The diffusion theory based calculated values of thermal flux profiles for axial as well as for radial directions have been found to agree well with the corresponding experimental measurements. The UO2 based LEU core has been found having flux spectrum closest to the reference core while U9Mo core has significantly harder flux spectrum at irradiation site. Fuel burn-up study and buildup of actinides and fission products for potential LEU fuels (UO2 and U9Mo) with existing HEU fuel (UAl4-Al, 90% enriched) for a typical Miniature Neutron Source Reactor (MNSR) has been carried out using the WIMSD4 computer program. For the complete burnup, the UAl4-Al, UO2 and U9Mo based systems show a total consumption of 6.89, 6.83 and 6.88 g of Relative to 0.042 g 235 U respectively. 239 Pu produced in case of UAl4-Al HEU core, UO2 and U9Mo based cores have been found to yield 0.793 and 0.799 g respectively indicating much larger values of conversion-ratios and correspondingly high values of fuel utilization factor. The end-of-cycle activity of the HEU core has been found to be 2284 Ci which agrees well with the value found by Khattab [48], where as for UO2 based and U9Mo based LEU cores show 1.8% and 4.8% increase with values of 2326 and 2394 Ci respectively. A two-group, three dimensional diffusion theory based methodology coupled with one-dimensional single-phase heat transfer calculations has been developed for the transient analysis of typical material test reactors (MTRs). This methodology has been implemented in a Fortran based computed program MTRAP3. It uses the CITATION computer program for static neutronic calculations while the group constant generation is performed by employing the WIMS-D/4 code. The MTRAP3 program uses Cranck- Nicolson (CN) based numerical scheme for solution of time dependent neutron diffusion calculations while time-implicit strategy is employed for detailed heat-transfer calculations. The CN-scheme has been found to remain stable for much larger time steps (∆t~10-5 s) as compared with the time-explicit scheme which remains stable for very small time steps only (∆t~10-10 s). For step as well as for ramp reactivity induced transients, the predicted values of core integrated reactor power and core average temperatures has been found to agree well with the corresponding values found by using the PARET computer program. The assembly-wise power profile as found by the MTRAP3 program has been found consistent with the corresponding experimental measurements.