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Impact of service quality on customer referrals the mediating role of costomer gratitude.

Thesis Info

Author

Najeeb Ullah

Supervisor

Sayyed Adnan Shabbir

Department

Department of Mnagement

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Page

98

Subject

Management

Language

English

Other

Ms658.812 NAI

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722549684

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پروفیسر ظہیر احمد صدیقی

پروفیسر ظہیر احمد صدیقی
افسوس ہے کہ ۱۷؍ فروری ۲۰۰۳؁ء کو پروفیسر ظہیر احمد صدیقی نے داعی اجل کو لبیک کہا، ان کی پیدائش ۱۹۲۹؁ء میں بدایوں میں ہوئی تھی اور وہ مولانا ضیاء بدایونی سابق صدر شعبہ فارسی کے صاحبزادے تھے، علی گڑھ میں تعلیم مکمل کرنے کے بعد یہیں استاذ ہوئے، مگر جلد ہی دہلی کالج اور پھر دہلی یونیورسٹی کے شعبہ اردو سے وابستہ ہوئے اور پروفیسر اور ڈین کے عہدے پر فائز ہوئے۔ حکیم مومن خاں مومن سے ان کی دلچسپی موروثی تھی، ان کی شخصیت اور فن پر ایک کتاب لکھی تھی، خواجہ میر درد، مولانا حالی اور فانی بدایونی پر بھی کتابیں یادگار چھوڑی ہیں، فکری زاویے اور احساس و ادراک ان کے مجموعہ مضامین ہیں، انجمن ترقی اردو ہند سے ان کا گہرا تعلق تھا، وہ اس کے نائب صدر تھے، اردو کے اچھے استاذ، ادیب، نقاد اور مصنف ہونے کے علاوہ بڑے خلیق اور شریف انسان تھے، ہر شخص سے خلوص و محبت سے پیش آتے تھے، وظیفہ یاب ہونے کے بعد علی گڑھ میں سکونت اختیار کرلی تھی، یہیں کی خاک کا پیوند بھی ہوئے، اﷲ تعالیٰ غریق رحمت کرے اور پس ماندگان کو صبر جمیل عطا کرے، آمین۔ (ضیاء الدین اصلاحی۔ اپریل ۲۰۰۳ء)

Development and Validation of a Self-Concept Scale for College Students Using Comics Superhero Characters

Self-concept refers to the domain of self-descriptions that have self-evaluative connotation. Though many researchers embarked in the study of self-concept, and some even developed tests that measured self-concept, majority of these instruments had methodological and theoretical problems due to lack of systematic instrument development and presentation. The objective of the study is to develop a reliable and valid alternative approach to measuring the self in a semi-structured undisguised comics-type test that directly accounts for the way college students consider their choices of superheroes’ traits that characterizes their own. A preliminary survey on self-concept, in a form of open-ended statements was conducted to five hundred ninety-eight (598) college students of selected schools in Manila and Bulacan to know how college students see themselves indicatory of their self-concepts. Results of which, were collated to form the preliminary form. The preliminary form of the SCSS was administered to five hundred ninety-five (595) college students of different universities and colleges. Eighty-eight (88) items under eight (8) components were subjected to item analysis by identifying factors through a series of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Descriptive results were also calculated, as well as the exact reliability coefficient through split-half and Cronbach’s alpha. For the validity, content analysis was applied using two groups of experts who ascertain the suitability of each item in terms of content, relevance, clarity, appropriateness and their representations. They include three (3) experts who have a long experienced in comics industry and another three (3) experts in the field of college students’ self-concept formation. From the total of 88 items, 30 items were eliminated. However, the items that constitute the final form of the SCSS was concentrated into 55 items under six (6) factors upon post-analysis consideration. Statistical analysis revealed that the experts’ ratings were consistent and has high reliability with a generated r value of.894. The SCSS final form was administered to 809 respondents following the same procedures that were used for the preliminary form. The test scores were subjected to reliability facility, such as Alpha Coefficient and Split-Half, computing the reliability coefficients of the final form. Validity was established through convergent analysis, tested in a sample of 419 respondents who took the Tennessee Self-Concept Scale (TSCS: 2) Adult Form. The test was found to have high reliability with r =.792.

Identification of Therapeutically Important Molecules Against Breast Cancer Cells

Breast cancer is the cancer that develops from breast tissues. Presence of a lump in breast tissue, discharge from the nipple or change in shape, size and color of breast are among the prominent signs of breast cancer.Several factors are responsible in increasing the risk of the development of breast cancer. These include obesity, alcohol uptake, lack of exercise, predisposing genes, and above all, female sex. A number of treatments are used for breast cancer, including chemotherapy, surgery, radiotherapy, and hormonal and targeted therapies. Intravenous chemotherapy which uses cytotoxic drugs is the hallmark of cancer treatment for decades. These cytotoxic agents mainly target rapidly dividing cells, and certain normal cells as well, thereby causing toxicities, such as myelosupression, gastrointestinal symptoms, and hair loss. Significant progress has been made in breast cancer treatment by using systemic agents (non-targeted therapies) and they are still the treatment of choice, despite the appearance of resistance to these treatments. In the recent past, there has been a dramatic shift in cancer therapy, from the use of cytotoxic agents to the development of targeted therapies. This was based on understanding the pathways involved in growth promotion, resistance to apoptosis, and invasive behavior of breast cancer cells. In the past decades, several molecular inhibitors have been identified and tested in clinical trials,that target cancer promoting molecules in cancer cells. Some of the targeted therapies for breast cancer include herceptin, gefitinib, erlotinib, lapatinub, bevacizumab, cetuximab, pertuzumab, etc. These targeted therapies target one or more members of the EGFR family. Apart from using single chemotherapeutic agents, polychemotherapy is also used routinely by offering a survival advantage as compared to single agent therapy. Combination therapies significantly improve the therapeutic outcome because they are administered at suboptimal doses, and thus show less toxicities. The present study was carried out to identify new effective agents against breast cancer cells and also to develop new combination therapies that target specific proteins that serve as oncogenic drivers in breast cancer cells. Our focus was to target tyrosine kinases that serve as signaling molecules for the constitutive proliferation of various cancers, including breast cancer. We selected two breast cancer cell lines for our study i.e. (1) MCF-7, an invasive breast ductal carcinoma cell line expressing estrogen and progesterone receptors, and to a small extent expressing EGFR, and is thus hormone- dependent. (2) MDA-MB-231. It is a cell line that does not express estrogen, progesterone and HER2 receptor, but it overexpresses an EGF dependent EGFR. In the first phase of the study, 1,200 fully characterized compounds were evaluated for their ctotoxicity against both breast cancer cell lines. Compounds showing the most potent activities were further selected for combination studies using three tyrosine kinase inhibitors, imatinib, genistein, and erlotinib, to study the synergistic interactions between the compounds in combination with tyrosine kinase inhibitors. In the second phase, successful synergistic combinations were selected for mechanistic studies. These combinations were tested for their apoptosis inducing potential, and it was found that these combinations significantly enhance the apoptotic death in breast cancer cells, as compared to the test compounds alone. These combinations were further tested for their effects on phosphotyrosylated proteome of the cells. The total phosphotyrosylated proteome was found to be unaffected, except for the diminishing expression in high molecular weight proteins. Based on these observation, the combinations were further tested for their effects on EGFR, and its phosphotyrosylated form (Y-1068). The combination of imatinib with endoperoxides and resveratrol was shown to inhibit the EGFR and P-EGFR expression on MDA-MB-231 cells, while in MCF-7 cells only P-EGFR expression was inhibited. Combination of genistein with one of the endoperoxide (Compound 34) was found to inhibit P-EGFR, but not EGFR in MCF-7 cells. Combination of erlotinib with thiazol derivatives (compounds 10, and 14) resulted in partial inhibition of EGFR, and complete inhibition of P-EGFR in MDA-MB-231 cells.Combination of erlotinib with a pyrimidine derivative (compound 30) resulted in complete inhibition of both EGFR and P-EGFR on MDA-MB-231 cells. Synergistic combinations were tested for their effect on caspases, involved in apoptosis induction of breast cancer cells. It was observed that in MDA-MB-231 cells apoptosis is induced by an intrinsic pathway through the activation of caspases 9 and 3 while in MCF-7 cells, the extrinsic pathway of apoptosis is induced through the activation of caspases 8 and 6. In conclusion, new synergistic combinations targeting EGFR have been identified and deserve to be further investigated in in vivo settings.