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Synthesis of Nucleobase-Functionalized b-Tripeptide Scaffolds for Higher Ordered Molecular Architectures

Thesis Info

Access Option

External Link

Author

Mehmood, Tahir

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2058

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727492472

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The stability of cyclic peptides and their self-assembling ability is an important aspect in the DNA recognition studies. Functionalization of cyclic peptides with nuclear bases may serve the purpose of mimicking and interacting with the DNA single strand. Stacking of the cyclic peptides after functionalzation may develop steric hinderance. L-Lysine, with side chain amino group, was selected to avoid these steric factors. Differently-protected L-lysine was transformed into its respective β-analogue using Arndt Eistert synthesis. These β-amino acids were utilized to synthesize cyclic β-tripeptide scaffolds through a multistep sequence. The scaffolds after deprotection were subjected to functionalization with the selected nuclear bases (adenine, thymine, cytosine and guanine) after conversion to their acetic acid derivatives. The nucleobase-functionalized cyclic β-tripeptide scaffolds were completely deprotected, purified by RP-HPLC and characterized by ESI and HRMS.
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احسان اﷲ ثاقب

احسان اﷲ ثاقب(۱۹۴۲ء۔۲۰۱۴ء) پسرور میں پیدا ہوئے۔ آپ معروف رومانوی شاعری فاخر ہریانوی کے بیٹے ہیں- اعلی تعلیم حاصل کرنے کے بعد محکمہ تعلیم میں ملازمت اختیار کی۔ (۹۸۲)آپ کا ایک شعری مجموعہ ’’شہرِ غزل‘‘ کے نام سے معراج پر نٹرز لاہورسے ۲۰۰۶ء میں شائع ہوا۔ اس کے علاوہ کچھ شعری مسودات ہیں جو شائع نہیں ہو سکے۔ احسان اﷲ ثاقب غزل گو شاعر ہیں۔ ان کا اردو ادب میں بڑا کارنامہ یہ ہے کہ انھوں نے اپنے شعری مجموعے ’’شہرِ غزل‘‘ میں بیس بحور کے چھیاسی اوزان میں بڑی خوبصورتی سے طبع آزمائی کی ہے۔ آج ارد وشاعری میں کوئی قدآور شاعر بھی اتنی تعداد میں بحور اور اوزان میں شعر نہیں کہہ سکا ہے۔ انھوں نے ایک نئی بحر کا بھی اضافہ کیا ہے۔ جسے انھوں نے ’’بحرِ مترنم‘‘ کانام دیا ہے۔ یہ بحر تمام عروضی تقاضوں کو پورا کرتی ہے۔

حوصلہ مندی ،بلند فکری ،اخلاقیات، پیارو محبت،سماجی شعور اور توحید احسان اﷲ ـثاقب کی شاعری کے اہم موضوعات ہیں۔ اس حوالے سے نمونہ کلام ملاحظہ ہو:

جسم کے روح سے رابطے ہیں بہت

 

;اس تعلق میں بھی فاصلے ہیں بہت

 

 

 

 

 

5عمر درکار ہے اس سفر کے لیے

 

7ہجر سے وصل تک مرحلے ہیں بہت

(۹۸۳)

 

 

 

 

9ہمیں چلنا ہے ترچھے زاویوں پر

 

;مگر رہنا ہے پھر بھی راستوں پر

(۹۸۴)

 

 

دراسة مقارنة في تعيين الزمان والمكان والأعلام عند شراح البخاري (الكرماني وابن حجر نموذجاً)

Sahih al-Bukhari by Imam Abu Abdullah Mohammad al-Bukhari comes second to the Holy Quran as a fundamental source of Islam. It is a most authentic collection of sayings and deeds of Prophet Mohammad (PBUH), which covers almost all aspects of life in providing proper guidance from the Messenger of Allah. The Muslim scholars of past and present time gave great importance to this book by making their efforts to extract the hidden treasures from this book and to present the different approaches and benefits of this book. “Al Kawakib Ad Durari” by Imam Alkirmani is an old explanation of Sahih Bukhari. During studying “Fath al Bari” I found that Alhafiz Ibne Hajar has consulted “Al Kawakib Ad Durari” and quoted Imam Alkirmani’s commentary and added it. Alhafiz Ibn e Hajar differs at many times with the opinions of Imam Alkirmani about specific time, place, different tribes and personalities mentioned in the text of traditions. I wanted to study such analysis to check the right opinion after comparing statements of both Imams and by consulting with the statements of other scholars of this field. This article approves that judgments of Ibn e Hajar about specific time, place, different tribes and personalities are more authentic than opinions of imam Alkirmani.

Study of the Testicular Atrophy Induced by Androgenic Anabolic Steroids and its Effect on Histology and Hormonal Level in Albino Rats

This research was undertaken to observe the harmful effect of androgenic anabolic steroids over the male reproductive system. A total of 120 animals were used. The animals were administered injection of androgenic anabolic steroid for short and long periods intramuscularly once a week. The animals were divided in the following groups (A) control / untreated males, (B) treated for short period i.e. acute group, (C) treated for long duration i.e. chronic group, and (D) group left untreated for another 14 weeks to see the withdrawl effects of the drug. The blood was drawn by cardiac puncture, for the estimation of serum concentration of reproductive hormones in male rats, including testosterone, LH, and FSH. Animals were sacrificed and testis were removed for the histological study and scanning electron microscopy, and were analysed statistically. Hormonal analysis revealed significantly decreased level (p<0.001) of FSH, LH and testosterone in acute and chronically treated groups, while the level of these hormones returning towards normal in the withdrawl group. The histological sections of the testis revealed that there is a time related effects over the spermatogenesis, resulting in the decrease in the relative weight of the testis, count and the number of seminiferous tubules along with the decrease in the number and the diameter of the interstitial cell nuclei in the treated animals. These results are further confirmed by performing scanning electron microscopy.2 While looking the effects in the group which has been withdrawn from the drug for another 14 weeks period shown that the animals in this group shown to return of all the parameters back to or near to normal. From these finding it can be said that the androgenic anabolic steroids has dose and time related effects over the male reproductive tissue i.e. the testis. But these effects can be reduced if the drug is withdrawn after confiming that they are produced after the therapy is started. From these findings it can be concluded that androgenic anabolic steroids has toxic effects on the germ cells depending on the time period. However, if the drug is withdrawn than the effects can be reduced. This aspect of the study needs to be further evaluated.