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زندگی خدا کی نعمت ہے

زندگی خدا کی نعمت ہے
اس کائنات رنگ و بو میں جہاں نظر دوڑائیں اُس منعم حقیقی کی عطا کردہ نعمتوں کی فراوانی ہی فراوانی ہے۔ کہیں کھیت وکھلیان کشت ِزعفران کا نمونہ پیش کر رہے ہیں، کہیں گلستان و نخلستان جشنِ بہاراں کی آمد کی نوید جانفراسُنارہے ہیں ، کہیں دریا اور نہر یں جوئے نغمہ خواں کی صورت میں موجود ہیں، کہیں کوہستانی علاقوں میں موجود فلک بوس پہاڑ اور جبال شامخہ ناظرین کو ورطۂ حیرت میں ڈال رہے ہیں۔ یہ سب اللہ تعالیٰ کی نعمتیں ہیں جو مختلف شکلوں میں موجود ہیں۔ لیکن ان سب سے بڑھ کر جواللہ تعالیٰ کی عظیم نعمت ہے وہ زیست ہے، وہ حیات ہے، وہ زندگی ہے۔
زندگی ہے تو سب نعمتیں رعنائیاں بکھیرتی ہوئی نظر آتی ہیں، زندگی کے حیات بخش قطروں سے سیراب شخص ہی جملہ انعاماتِ ربّانی سے متمتع ہوسکتا ہے، زندہ شخص ہی بادِنسیم کے مسحور کن جھونکوں سے مسرور ہوسکتا ہے، زندگی ہی گلہائے گلستان ونخلستان کی حسن و زیبائش کا احساس دلاسکتی ہے، زندگی سے حرکت ہے، زندگی سے برکت ہے، زندگی سے عبادت ہے، زندگی سے عیادت ہے۔ انسان کا وجود، قوم کا وجود ، معاشرے کا وجود ملک و ملت کا وجود زندگی کا ہی مرہونِ منت ہے۔
زندگی کی حقیقی رعنائیوں سے فائدہ اٹھانے والے ذی فہم فراست لوگ آسمان علم و دانش پر آفتاب و ماہتاب بن کر چمکتے ہیں، وہ اس حقیقت کو بھی فراموش نہیں کرتے کہ یہ زندگی ہمارے پاس اللہ تعالیٰ کی دی ہوئی امانت ہے، ہم نے اس میں خیانت نہیں کرنی ہے، ہم نے اپنی زندگی کو اُسی راستے پر گامزن کرنا ہے جہاں خالق حقیقی کی منشاء و مراد ہے۔
قرآنِ پاک میں ارشادِ باری تعالیٰ ہے کہ ’’ ہم نے انسان کو اور جن کو صرف اس لیے پیدا کیا...

DEPRESSION AND PSYCHOLOGICAL WELL-BEING AMONG PEOPLE HAVING COVID-19 UNDERGONE QUARANTINE

Aims Of Study: Coronavirus is a potentially deadly disease that mostly affects human lung tissue. Multiple cases of unexplained respiratory tract infections were reported to the World Health Organization China in December 2019. The focus of this research was to assess association between depression and PWB in patients who had been isolated due to covid-19. Methodology: A sample of 250 people with covid-19 post quarantine, with age ranges from 25 to 45 were selected by using purposive sampling methods. Depression, anxiety, stress scale and psychological well-being scales were administered. Regression analysis and t-test were employed for statistical analysis. Results: Obtained results evidenced that depression is significantly predict psychological health in the covid-19 population [B= -.015, -.019, F (7.915) sig= .000]. Gender difference is also observed in variable of depression also [(4.78) =.030, p.000]. Limitations and future implications: Future research may base on longitudinal analyses focusing on familial and social factors that may influence the psychological well-being of people living in quarantine. Originality: I certify that the intellectual substance of this article is the result of my own effort and that all assistance and sources used in the preparation of this article have been acknowledged. Conclusion: It was concluded that Depression affects people with COVID-19 and PWB after quarantine. future research may focus more on the influence of the interaction between quarantine and adults’ mental health to fully comprehend the link. 

444A Study of Genetic Polymorphism of Gstm1 and Gstt1 in Healthy Volunteers and Leukemic Patients

Genetic polymorphism might be consider as a marker for predisposition of different diseases including leukemia. Glutathione S Transferase has role in metabolism of different types of Xenobiotics to facilitate their excretion from the body. It has also role in the metabolism of the drugs used in chemotherapy for different diseases. There are many genes that exhibit polymorphism but most of them show single nucleotide polymorphism. The deletion of whole gene is rare. GSTM1 and GSTT1 members of glutathione family are polymorphically deleted. Purpose of the study was to investigate deletion of these two isozymes in local Pakistani population and to investigate if any relationship exists in leukemic population. Male and females of healthy and leukemic patient volunteers were selected. Leukemic population was further divided into different groups (ALL, CLL, AML and CML). Biochemical parameters and oxidantion status of all patients and healthy volunteers were measured by kit method and Genetic polymorphism was seen by PCR and gel electrophoresis. Total bilirubin, creatinin, urea and ALT is greater in patients compared to healthy volunteers. Total oxidant status was low while total antioxidant status was high in healthy volunteers compared to patients depending on disease condition. Healthy subjects show 54% deletion of genes (66% and 52% in female and male respectively). Patients show 67% deletion of GSTM1 gene in which ALL 66% (68% and 76%, CLL 70% (80% and 60%), AML 70% (72% and 68%) and CML 62% (60% and 64%) in female and male respectively. GSTT1 deletion found healthy volunteers was 71% and it is 72% and 70% in female and male respectively and was found 70% in leukemic patients. ALL 78% (76% and 80%), CLL 76% (80% and 76%), AML 66% (76% and 76%) and CML 60% (56% and 64%) female and male respectively. All patients and healthy volunteers have more than 50% deletion of GSTM1 and GSTT1 genes. More deletion of GSTM1 was seen in patients than healthy volunteers while local population seems to be more prone to leukemia and may respond less to some chemotherapeutic drugs.
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