Analysis of Rights of Foetus in the Light of Searah Nabviyah: Comparative Study With Positive Law

The article titled: the rights of foetus in Islamic law, aims at explaining the rights of foetus without discussing different theories of the scholars in this regards. It also defines the foetus and gives literal and technical meanings besides different stages of foetus mentioned in the Holy Quran and the Hadith. The article explains the rights granted to foetus in the lights of serah before birth and these rights are a binding on the concerned people and violation of foetus’ s rights is prohibited and it is a cognizable offence. The article also discusses the attitude of west regarding foetus rights as the western society is totally ignorant about the rights of foetus and their legislation in this regard is contrary and several western laws are causing the violation of foetus’s rights. Thus, the champions of human’s rights are blind to the rights of foetus which is foundation and beginning of human life and first step for the human race. It is that has given these rights to mankind for the first time and informed human being about their rights through the first human’s rights charter given at the time of the Noble Prophet {blessing of Allah and peace be upon him}. This charter is known as the charter of Madina between the Muslims and the Jews. The article concludes: mankind cannot be protected unless the sperm of man is protected and foetus is protected in the womb of the mother from abortion because these are the future of humanity.

Association of Tissue Vitamin D Receptor Expression With Breast Cancer Molecular Subtypes in Kenyan Women

Background: Previous studies have shown that reduced vitamin D receptor expression in breast cancer tissue is associated with worse disease outcomes. Furthermore, studies show that estrogen negative and triple negative breast cancer is associated with a poor prognosis and a low breast tissue vitamin D receptor (VDR) expression. Other studies also report that low serum vitamin D levels are associated with more aggressive breast cancer. Methods: This was a cross-sectional study with both a retrospective and a prospective arm. The retrospective part was nested within a larger study; previously constructed tissue microarray blocks (TMA) blocks were used for analysis of VDR expression. The prospective arm recruited women who underwent a breast biopsy for suspicious breast lesions in whom blood samples for serum vitamin D levels and tumour VDR immunohistochemistry were collected. Questionnaire data on pre-determined patient and tumour characteristics were extracted from the charts. Tissue expression of VDR was analysed on immunohistochemistry and serum vitamin D levels assayed. Results: A total of 214 cases were recruited retrospectively and 24 prospectively. There was a statistically significant difference in the VDR score of the Triple negative breast cancer (TNBC) subtype compared to the other subtypes (p value = 0.047, test = ANOVA: Kruskal Wallis Test). There was a positive correlation of VDR score and tumour size. There was a weak negative correlation between VDR score and human epidermal growth factor receptor 2 (HER 2) but no correlation with ER and PR. There was a positive correlation between serum vitamin D levels and VDR Immunoreactive score (IRS). Conclusions: Our results suggest that low or negative VDR score is a marker of poor prognosis in breast cancer as the expression was low in TNBC. However, high VDR score was not associated with ER or PR expressing tumours. The weak negative correlation with tumour size suggests an association of low VDR expression with aggressive tumour features. A randomized controlled trial exploring the utility of vitamin D supplementation or other VDR ligand analogues in TNBC is recommended. A larger study is recommended to determine if indeed there is a correlation between serum vitamin D levels and VDR expression.