Iron deficiency and risk of oral squamous cell carcinoma Iron expression in oral carcinoma

Oral squamous cell carcinoma (OSCC) is a subset of head and neck squamous cell carcinoma caused by excessive substance abuse like alcohol, tobacco etc.  Objectives: Aim of the present study was to evaluate the iron expression in different grades of OSCC and potential of iron staining as a prognostic marker and its importance as an essential nutrient in diet. Methods and Patients: It was a cross sectional study.A total of 40 oral biopsies were evaluated and the mean age of patients was 53.5 years with age range 23-80 years. 14 cases were well differentiated, 14 moderately differentiated and there were 12 poorly differentiated case. Iron staining was performed for all these cases. Results: Iron positivity was observed in 11 (27.5%) of OSCC patients with maximum iron positivity in well differentiated group (64.28%) of age range 20-40 years (70%). More patients had tongue as site of cancer. There was no genderwise difference in iron expression. Iron deficiency was associated with poor prognosis indicating iron as an important nutrient which can prevent OSCC if adequately present in our routine diet. Conclusions: Prevalence of iron positivity in young patients and initial stage of OSCC, indicates the protective effect of iron against oral squamous cell carcinoma

Simplified Fdd Process Model

Feature driven development (FDD) is a process oriented and client centric agile software development model which develops a software according to client valued features. Like other agile models it also has adaptive and incremental nature to implement required functionality in short iterations. FDD mainly focuses on designing and building aspects of software development with more emphasis on quality. However less responsiveness to changing requirements, reliance on experienced staff and less appropriateness for small scale projects are the main problems. To overcome these problems a Simplified Feature Driven Development (SFDD) model is proposed in this research. In SFDD we have modified the phases of classical FDD for small to medium scale projects that can handle changing requirements with small teams in efficient and effective manner.