63. Al-Munafiqun/The Hypocrites
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone
63:01
a. When the hypocrites - disbelievers showing belief - come to you, O The Prophet, they
pretend to say:
b. ‘We bear witness that you are certainly Allah’s Messenger.’
c. And without the need for the testimony of the hypocrites, Allah knows very well that you are indeed HIS Messenger,
d. but Allah also bears witness that the hypocrites are definitely liars – saying what they do not mean.
63:02
a. They choose their swearing as a cover-up, a deceit;
b. while in reality, they obstruct people from the Way of Allah.
c. Surely they - evil indeed is what they do.
63:03
a. That is what has happened because first they believed and then inwardly they disbelieved.
b. Hence, their hearts have been sealed -
c. such that they do not comprehend the concept of truth.
63:04
a. And whenever you would look at them, you would be impressed by their physical stature,
b. and when they speak, you would listen to their speech attentively.
c. But, in fact, they are just like logs of timber/wood, stacked-up against a wall.
d. They reckon that every rebuke they hear is directed against them.
e. These are the real and bitter enemies;
f. so beware of them!
g. May Allah destroy them!
h. How deluded they are!
63:05
a. And whenever they would be asked:
b. ‘Come to offer apologies and let Allah’s Messenger seek forgiveness for you’ of hypocrisy and deceit.
c. They would twist their heads in arrogance,
d. and you would see...
The aim of Hijrah is philosophically viewed as a way to spread Islam wisely. This was by Allah’s guidance and directive amidst the very bitter atmosphere in Makkah at that time against the early followers of the Islamic religion brought by the Rasulullah (pbuh). The prophetic Hijrah observed from the way it impacted Makkah and Madinah’s societies can be construed as a very important event that provided us with a variety of messages. It also acts as a reflection of our contributions to da’wah and the roles we can assume as good Muslims, by looking at what the Rasulullah (pbuh) and his companions had themselves sacrificed in the Hijrah. In short, Al-Hijra is the time when the Prophet Muhammad (pbuh) and his followers moved from Makkah to Madinah, where they set up the first Islamic state. Islam needed to expand and spread in the world, so the migration resulted in the expansion and preservation of Islam and Muslims. The Rasulullah (pbuh) migrated to Madinah when his enemies in Makkah mistreated him and his followers. It is a fact that the early Muslims in Makkah were greatly troubled by the unbelievers of Quraisy, the tribe of the Prophet (pbuh). The Rasulullah’s (pbuh) popularity in his da'wah efforts to invite his people to Islam was seen as threatening by the people in power in Makkah. The context of Hijrah was seen as urgent and timely as the unbelievers in Makkah had escalated the persecution against Muhammad (pbuh) and his followers. This persecution and a directive from Allah were the main reasons for the migration.
Present study is about Skimmia laureola and Zanthoxylum armatum belonging to Family Rutaceae, comprises phytosociology, ethnobotany, pharmacognostic study, physicochemical and pharmacological activities of these plants. Phytosociological attributes of S. laureola were studied in six different localities of khyber Pukhtunkhwa, Pakistan showing that this plant grows gregariously in laomy and clay loamy soil at high altitude ranging from 2400- 3400 meters toward North facing slopes. S. laureola was found dominent in five out of six localities in association with a total of 44 plants with a density of 312 to 4437.5 hectare-1. Various other ecological, ethnobotanical and commercial aspects of the plants are also worked out. Similar studies of Z. armatum showed that the plants grows in association with 51 species on the North and North West slopes in the foothills of khyber Pukhtunkhwa at an elevation of 850- 1600 meters with a density ranging from 560 to 1020 hectare-1. Pharmacognostic study included leaf and bark of S. laureola and leaf, bark and fruit of Z. armatum. Leaf of S. laureola is punctate with glabrous surfaces. Transverse section of the leaf through the midrib region showed usual bifacial structure with prominent oil cavities in the midrib regions. Other leaf features such as palisade ratio (7.8±0.21), vein islets number (15.4±0.63 per mm2), vein termination number (19.1±0.43 per mm2), stomatal number (196.1±3.07 per mm2) and stomatal index (12.96±0.14) were worked out. Eight different stomatal types were detected, in which actinostephanocytic was the most frequently occurring one . Stomatal cluster was also observed. Morphology and anatomy of Z. armatum was also carried out. Leaf of this plant lacks any type of trichome, where as in the midrib region, prominent oil cavities were observed. Palisade ratio (8.2±0.32), vein islets number (16.8±0.64 per mm2), vein termination number (11.3±0.47 per mm2), stomatal number (122.1±4.32 per mm2) and stomatal index (12.32± 0.26) were cworked out. Anatomy of Z. armatum fruit showed two portion i.e. fruit wall and seed, the later being non endospermic and contained small elongated embryo. Powder drug microscopy of the parts was carried out. Ash analysis for both plants were carried out. Results of qualitative and quantitative preliminary phytochemical screenings of selected parts of S. laureola and Z. armatum are given, showing the presence of carbohydrates, proteins, alkaloids, phytosterols, triterpenoids, phenols, flavonoids, tannins, anthocyanins, saponins, glycosides, fixed and volatile oils. Similarly results of extractive values and fluorescence analysis are also given. Elemental analysis showed presence of Zn, Mn and Cr in fairly good amounts and may contribute to hypoglycemic effect of these plants. Correlations among various elements were also determined. Proximate analysis of both plants showed carbohydrate, proteins, fibers, fats and moisture contents in fairly large amounts. Results of essential oils obtained from the leaves of S. laureola (SVO) and Z. armatum (ZVO) and fixed oils (ZHO and ZEO) from the fruit of Z. armatum, extracted with different solvents were evaluated for physicochemical characteristics including color, odor, % yield, density, optical activity, refractive index, specific gravity, carbon residue, absolute viscosity, kinematic viscosity, total acid number, iodine number and saponification value are presented. A total 31 different components in SVO and 34 in ZVO, 14 in ZHO and 14 in ZEO were identified through GC-MC analysis and their percent concentration is given. Toxicological studies showed that both plants are safe for human use. Antipyretic effect was found dose dependant. SLE showed maximum antipyretic action of 72.31%, ZLE showed 85.42 percent pyrexia inhibition of whereas ZFE showed a maximum antipyretic action of 83.84%. Hypoglycemic effect of SLE was found to be dose dependent and like the standard allopathic drug and it induced reduction of blood glucose level after 2 hour of dose administration. All the doses showed significant reduction (p < 0.05) in glucose level at 6th hour post administration, but 300 mg/Kg body weight dose showed maximum reduction of blood glucose level at 6 hour (80.54±0.04). Antispasmodic effects of ethanolic and n-hexane extracts of leaf (SLE, SLH), bark (SBE, SBH) and leaf essential oil (SVO) of S. laureola and ethanolic and n-hexane extracts of leaf (ZLE, ZLH), bark (ZBE, ZBH), fruit (ZBE, ZBH) and leaf essential oil of Z. armatum on the isolated rabbit jejunum for both spontaneous and KCl induced contractions showed that SVO and ZVO were the most efficient one, causing 100 % relaxation of the smooth muscles at very low concentrations, thus providing a scientific proof for its ethnopharmacological use as an antispasmodic drug. The two plants were also evaluated for cytotoxic, phytotoxic, antibacterial and anti fungal activities. SLE, SLH and SVO of S. laurola and ZBE, ZBH and ZVO of Z. armatum showed outstanding cytotoxic results with LD50 values of 5.34, 7.44, 11.01, 16.79 17.06 and 15.90 μg/ml. respectively. Lemna minor phytotoxicity asssay of SBE showed 100% inhibition at 1000 μg/ml followed by SBH, SLE and SLH with FI50 of 25, 1.38, 4.54 and 8.67 μg/ml respectively. ZBE, ZFE and ZLH also showed excellent inhibitions with FI50 values of 7.98, 9.24 and 19.13 μg/ml respectively. Antibacterial bioassays showed that all the samples were effective against various bacterial strains (Micrococcus leutus, Escherichia coli, Staphylococcus aureus, Pasteurella multocida, Pseudomonas aeruginosa, Bacillus subtilis, and Streptococcus viridanes). SVO and ZVO being the highly effective against all the test strains. Results of various extracts of both plants against various bacterial strains are presented in this dissertation. Dose dependent antifungal activities against test species (Trichophyton longifusis, Candida albicans, Fusarium solani, Microsporum canis, Aspergillus flavus and Candida glabrata) were found for all the samples but SVO and ZVO inhabited all the test strains and C. albicans, A. flauus, T. longifusis and F. solani being the most susceptible species. The present study has revealed the immense and diverse medicinal properties of S. laureola and Z. armatum, both can be exploited for therapeutic preparations on commercial scale.