خطبات ِ استفہامیہ کے اسرار و حکم و امثال
قرآن مجید میں کثیر آیاتِ مبارکہ ہیں جن میں استفہامیہ اندازِ خطاب اپنایا گیا ہے ۔ چونکہ قرآنِ مجید کا یہ اعجاز ہے کہ اس میں بہت سے اسرار و رموز چھپے ہیں جو کہ گرائمر اور علوم و فنون کے اعتبار سے مختلف ہیں۔ لہذا فصل ہذا میں قرآن مجید سےحروف ِ استفہامیہ اور اسمائے استفہامیہ پر مشتمل آیات کو نقل کیا جائے گا اور تفسیری اسرار و حکم کو بیان کیا جائے گا۔
For the development of Muslim society it is necessary that its people should be trained on the basis of Islamic teachings. This could not be possible until we design a curriculum of seerah which is according to the contemporary needs of character building. The purpose of designing such curriculum is to train our youth in such a way that they would be able not only to take advantage from our rich tradition but also they are well prepared to hold the leadership of the country. We have to keep in mind, while designing seerah curriculum, that it is not revealed. Infact we have to design it according to the needs of hour. If we keep in consideration the ideological and contemporary requisites than we would be able to get the desired results. Islam provides basic principals in this regard. Following these instructions we would be able to design a curriculum which produced the required results.
Present study complies with different principles of green chemistry utilizing efficient instrumental techniques i.e; microwaves, ultrasonic waves and replacement of hazardous solvents with greener ones. The overall progress of chemical reactions achieved through application of green chemistry, was compared with the traditional methods. In the first part of this research work, synthesis of N’-benzylidene-2-(2-fluorobiphenyl)propanehydrazides was carried out for which, 2-(2-fluorobiphenyl-4-yl)propanoic acid was esterified to methyl 2-(2- fluorobiphenyl-4-yl)propanoate under the influence of microwaves followed by its hydrazinolysis. 2-(2-Fluorobiphenyl-4-yl)propanehydrazide thus obtained, was then reacted in an ultrasonic bath with different benzaldehydes to get a series of N’-benzylidene-2-(2- fluorobiphenyl)propanehydrazides. In the second series, 2-(2-fluorobiphenyl-4-yl)propane hydrazide was converted to 4-amino-5- [1-(2-fluoro-biphenyl-4-yl)-ethyl]-4H-[1,2,4]triazole-3-thiole followed by its reaction with different benzaldehydes under conventional and green technologies to get a series of 4- (benzylidene-amino)-5-[1-(2-fluorobiphenyl-4-yl]-4H-[1,2,4]triazole-3-thiole compounds. In another series, different substituted chalcones were prepared by clasian condensation method which were then reacted with 2-(2-fluorobiphenyl-4-yl) propane hydrazide in a mixture of water and ethanol to get a series of 2-(2-fluorobiphenyl-4-yl)-propionic acid(1,3- diphenyl-allylidene)-hydrazide. These reactions were conducted utilizing green technologies and were compared with using conventional methods. Comparison of both the conventional and microwaves/ultrasound assisted reactions indicates a significant reduction in reaction times and improvement in reaction yields. Besides, chemical characterization and X-ray crystallography of selected compounds, all the synthesized compounds were evaluated for their anti-oxidant potential [Total anti-oxidant activity, ferric reducing anti-oxidant power (FRAP) and total phenolic contents], and analgesic activities using (tail flick, hot plate and writhing methods) and most of them were found to possess potential as lead compounds for drug discovery.