ردد کامعنی ہے کسی شےکالوٹنا ، مسلمان کا کفر کی طرف لوٹ جانا۔ اس حوالے سے ابن فارس لکھتے ہیں
الراء والدال أصلٌ واحدٌ مطّردٌ منقاس، وهو رَجْع الشَّيء. تقول: ردَدْتُ الشَّيءَ أرُدُّه ردّاً. وسمِّي المرتدُّ لأنّه ردّ نفسَه إلى كُفْره.143
"مادہ " رَدَدَ " ہے اور اس معنی ہے کسی شے کا لوٹنا جیسے تو کہے ردَدْتُ الشَّيءَ أرُدُّه ردّاً میں نے فلان چیز کو لوٹا دیا اور مرتد کو مرتد اس لیے کہتے ہیں کہ وہ اپنے آپ کو کفر کی طرف لوٹا دیتا ہے ۔ "
اسلام سے پھر جانے کوارتداد کہتے ہیں، جیسا کہ ابن منظور کے نزدیک ارتداد
"وفي التنزيل من يرتدد منكم عن دينه والاسم الرِّدّة ومنه الردَّة عن الإِسلام أَي الرجوع عنه وارتدَّ فلان عن دينه إِذا كفر بعد إِسلامه۔"144
"اور قرآن مجید میں ہےمن يرتدد منكم عن دينه۔ ۔ ۔ الیٰ آ خرہ ۔ اور اسی سے ہے الردۃ عن الاسلام یعنی اسلام سے پھر جانا جیسے کہا جاتا ہے فلاں شخص مرتد ہو گیا جب کہ وہ اسلام سے کفر کی طرف پھر جائے ۔ "
ارتداد کے معنی اسلام قبول کر لینے کے بعد اسلام کو چھوڑ دینے اور اس کے خلاف بغاوت کرنے کے ہیں، جیسے امام راغب اصفہانی نے ارتداد سے متعلق تحریر کیا ہے
"والردۃ الرجوع فی الطریق الزی جاء منہ لکن الردۃتختص بالکفر والارتداد یستعمل فیہ وفی غیرہ۔" 145
"اس راستے پر پلٹنے کو کہتے ہیں جس سے کوئی آیا ہو لیکن ردۃ کا لفظ کفر کی طرف ہی لوٹنا خاص ہے اور ارتداد عام ہے جو حالت کفر اور غیر دونوں کی طرف لوٹنے پر بولا جاتا ہے۔ "
اصطلاحی مفہوم :علاؤالدین کاسانی ؒ شرعی اصطلاح میں ارتداد کے بارے میں لکھتے ہیں
"فَالرُّجُوعُ عن الْإِيمَانِ يُسَمَّى رِدَّةً في عُرْفِ الشَّرْعِ۔ "146
"پس ایمان سے پلٹ جانے کو...
Human history is replete with preposterous and unjustifiable incidents of unearned sufferings against the women. Sometimes they were maltreated and molested harshly and sometimes they were abused, persecuted bestially. Contrary to these incidents occasionally they were considered superior and super angelic but on the contrary Islam has bestowed a dignified status to them regarding their rights and responsibilities. In this regard a comprehensive manifestation has been introduced by the Islam and until this manifestation was being followed by the Muslims no single complain was lodged by any woman against the violation of her basic in the Islamic societies till the climax of Islamic regime. But today some European countries are holding discussions to impose illegal sanctions against the veil of women and girls. The parliament of France has approved a discriminatory law against veil of the Muslim women or girls. It is amazing that Christian nun is at her liberty to cover her head with scarf or not but if Muslim women consider themselves safe in veil they are contemptuously scorned with derision and disdained. In this article views of France and Islamic teachings have been brought under discussion.
Background and Objective A foremost step towards targeted administration of therapeutic agents is the formulation of novel drug delivery systems. Oral route is the most preferred and desired route of administration as a non-invasive mean of transporting drug to a target site. The aim of current research work was to design site-specific hydrogels for target delivery of oxaliplatin, an anticancer agent, used for the treatment of colorectal cancer. Six different types of hydrogel formulations were synthesized by different proportions of polymers and monomers. Another objective was to conduct an oral acute toxicity study of drug carrier polymeric systems on rabbits. Methodology A chemical cross-linking technique, free radical polymerization was chosen for preparation of polymeric networks. Six different combinations i.e. CS-co-poly(MAA), CS-co-poly(AA), PEGMA 4000-co-poly(MAA), PEGA 4000-co-poly(AA), PEGMA 8000-co-poly(MAA) and PEGA 8000-co-poly(AA) hydrogels were fabricated and their response to buffer solutions of different pH i.e. pH 1.2 and pH 7.4 was studied. Cross-linking structure of all formulations were evaluated by Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD). For thermal stability all combination of hydrogels were also subjected to thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. In-vitro drug release studies of all formulations were carried out in simulated gastric fluids. Moreover, in-vivo analysis of the best formulations was also conducted after the development of HPLC method. The drug release profile was evaluated by the application of zero order kinetics, first order kinetics, Higuchi model and Korsmayer- Peppas model. Oral acute toxicity study was also conducted for four formulations (CSA, CSMA, PEGA 4000, PEGMA 4000) by oral administration of drug carrier polymeric systems to healthy rabbits. Results All results of characterization confirmed the formation of newly developed polymeric hydrogels. Moreover, hydrogels were selected on the basis of their in-vitro studies and subjected to in-vivo evaluation. High performance liquid chromatography (HPLC) method was developed and validated for in-vivo analysis. The study was performed on thirty six xxvii rabbits and liquid-liquid extraction procedure was adopted for isolation of oxaliplatin from plasma samples. The bioavailability and pharmacokinetic parameters were computed by using a software PK Solver Add Inn program. Toxicity study which was conducted on five groups of rabbits, showed no toxic effects on biological systems of newly fabricated polymeric drug delivery systems. Conclusion From findings of our study it could be concluded that among six different cross-linked polymeric networks, PEGA 8000-co-poly(AA) and CS-co-poly(AA) hydrogels could be considered as superior as it showed better in vitro/in vivo release profiles and thus proven suitable for target delivery of Oxaliplatin to a specific site to treat colorectal cancer. Moreover, toxicity studies revealed that developed formulations were non-toxic to the biological system