قاری محمد یوسف
قاری محمد یوسف صاحب ندوۃ المصنفین کے یوم تاسیسں سے۱۹۵۱ء تک ادارہ سے برابر وابستہ رہے لیکن ان کاتعلق دفتر سے تھا اس سے بھی بڑھ کر ہم لوگوں سے ان کابڑا تعلق یہ تھا کہ وہ خود دیوبند کے فارغ التحصیل اورمولانا قاری محمد اسحاق صاحب میرٹھی جو حضرت مفتی عزیز الرحمن صاحب(والد ماجدمولانا عتیق الرحمن عثمانی) کے خلیفۂ مجاز اورایک بلند پایہ صوفی اورعارف باﷲ تھے، ان کے صاحبزادے تھے۔ ۱۹۳۷ء سے پاکستان جانے تک قاری اورمترجم کی حیثیت سے آل انڈیا ریڈیو سے برابر وابستہ رہے اوربہت مقبول تھے۔ترک وطن کے بعد حیدرآباد سندھ میں ناظم تعلیمات اسلامی کی حیثیت سے برسوں کام کیا۔ دوتین سال سے بعض خانگی حوادث کے باعث خانہ نشین ہوگئے تھے۔انتقال کے وقت۷۲۔۷۳ برس کی عمرہوگی۔اللھم اغفرلہ وارحمہ ۔
[فروری۱۹۷۱ء]
Holy Quran is the most sacred scripture bestowed by Allah Almighty upon his bellowed prophet Muhammad (PBUH). Unlike other scriptures, Allah Almighty himself took the responsibility of safety and safe custody of the Holy Quran. That is why, despite passage of more than 1400 years, the Holy Quran remained intact, wordwise as well as meaningwise and will remain intact till the end of the world. Such a unique status of the Holy Quran could not be tolerated by the enemies of Islam and Prophet of Islam. Therefore, they decided to present Holy Quran as a defective document before its readers. For this purpose, they chose to highlight and exploit the short and abbreviated incidents, described by the Holy Quran, under the term of “Muthashalihat”, by adding and narrating false, nonsense and most astonishing stories, just to divert attention of the readers from the basic learning of Holy Quran, towards un-realistic and bogus stories. Accordingly majority of the readers have shown great interest in these stories, which fall under the title of Israiliat Unfortunately, the said stories are included in dozens of Translations Tafaseer of the Holy Quran. In order to acquaint readers of the actual status of Israiliat, the undersigned has started working on the subject. Since Tafseer-e-Jalalain is included in the Syllabus of Maddaris and being taught for the last many years, therefore, I have chosen the same in the first instance, and pray Allah Almighty to help me out in completing my assignment.
Background: Intravenously administered iodinated contrast media are widely and liberally used in daily diagnostic radiological investigations. Contrast-induced nephropathy (CIN) is notable as the third commonest cause of hospital-acquired renal injury.
Justification: The global prevalence of CIN from various studies ranges from 2-5% but an incidence of CIN of 12-14% in Kenya was highlighted by a recent study without an explanation for the markedly increased incidence. Intravascular contrast has been demonstrated to commonly cause renal vasoconstriction. However, the low incidence of CIN in the general population infers that contrast alone cannot be a causative insult. This study proposes that inflammatory states, which are prothrombotic, when coupled with renal vasoconstriction may confer a higher relative risk for development of CIN. Objective: To determine the risk of developing CIN given the presence of an inflammatory state in patients presenting to a private university hospital in Kenya.
Study design: Prospective cohort study of patients undergoing a contrast- enhanced CT scan (CECT) in Aga Khan University Hospital, Nairobi (AKUHN) Radiology department and who have no known risk factors for CIN.
Methodology: A total of 423 patients were recruited over a period of 4 months. The patients were grouped into those without inflammation (unexposed) having serum C-reactive protein (CRP) levels ≤5mg/dL and those with inflammation(exposed) having CRP levels >5mg/dl. Serum creatinine (SCr) was measured before the CECT and 48 hours following the CECT with CIN diagnosed when there was an increase of >25% in the SCr from the baseline value. Relative risk was determined and multiple logistic regression analysis performed on the biophysical variables (age, weight, sex) and contrast volume to assess their effect on development of CIN.
Results: CIN was present in 42 (9.92%) patients. Of the exposed group (elevated CRP), 29 out of 215 patients (13.5%) developed CIN. In the unexposed group, 13 out of 208 patients (6.25%) developed CIN. This gave arelative risk of developing CIN of 2.16(1.15 to 4.04, P=0.016).The attributable risk percentage is 7.24% (1.1% to 12.2%). No statistically significant association was seen between the biophysical variables and volume of contrast and development of CIN.
Conclusion: Inflammation doubles the likelihood of development of CIN. Therefore a patient presenting with inflammation and any other risk factor for CIN should have a risk-benefit analysis to assess the need for administration of iodinated intravenous contrast.