الشفاء بتعریف حقوقِ مصطفیٰ ﷺ کا تعارفی و تجزیاتی مطالعہ An Analytical Study of the “Al-Shifā Ba Ta‘rīf-e-Ḥuqūq-e-Muṣṭafā”

The most prominent and living name among the African biographers is Qazi Ayaz Mālkī. His book “Al-Shifā Ba Ta‘rīf-e-Ḥuqūq-e-Muṣṭafā” has an important place in the books of Sīrah and also has the status of the most popular book among all kinds of people. This book is also called Kitab-e-Shifā (meaning the one who revives hearts and heals from heart diseases). The reason for writing this book was that the people were becoming oblivious to the obligatory status and virtues of the Holy Prophet ﷺ and were becoming completely incapable of paying their dues. In these circumstances, the demand for preparation and compilation of a collection of rights and manāqibs related to it became intense and he compiled this magnificent book. On the one hand, it teaches love and respect for the Prophet (peace and blessings of Allah be upon him) and on the other hand, it mentions his rights and rewards for fulfilling them. The writing style of the book is simple and smooth as well as eloquent. The book is not so long that it would be too long for the reader to comprehend, nor is it so short that it would not be possible to get access to the concepts and demands due to its brevity. The people have made this book their favorite and have been studying it and the biographers have adopted Al-Shifā as an authoritative and reliable source. Because of its importance and usefulness, an introductory and analytical study of this book will be presented in this article.

Insights into Hepatocellular Carcinoma Hcc by Employing Integrative Informatics Approaches

Contemporary approaches targeted towards precision medicine have shown significant achievements in most of the cancers by generating ‘big data’ across a range of high-throughput experimental and analytical podiums, yet significant problems remain. Integrative scrutinization of this data represents one of the greatest bottlenecks in cancer and other diseases. Surmounting this limitation necessitates integrative analysis of multiple layers of molecular information. Cancer represents a growing source and principal cause of morbidity and mortality in the human population, continuing to stymie clinical treatment efforts. Among various cancers, hepatocellular carcinoma (HCC) is now becoming the fastest growing cancer globally, mainly driven by the ageing HCV/HBV population and extremely limited therapies. There is currently considerable imprecision in optimal diagnostic and therapeutic strategies for HCC. The mounting assemblage of high-throughput data available in publicly accessible databases provides valuable source for generating preliminary in-silico data in support of novel conjectures. Bioinformatic initiatives that combine large amounts of cancer data represents an emerging frontier and are likely to play increasingly important roles. Current study endeavored to define an optimal and feasible method in order to gain new insights into HCC. Our comprehensive integrated analyses found seven novel HCC-specific circulating protein biomarkers including HSD11B1, SERPINC1, C8A, ADH6, CYP2A6, MBL2, UPB1, four highly deleterious HCC-associated Single-nucleotide polymorphisms (SNPs) including SCD1 R126S, SCD1 Y218C, BECN1 I403T, LC3B Y113C, seven miRNAs belonging to miR-17-92 cluster (has-miR-17-3p, has-miR-17-5p, has-miR-19b, has-miR-19a, has-miR-18a, has-miR-20a and miR-92) having a significant impact on drug resistance in HCC as well as uncovered new details about the potential Abstract xx role of circular RNA circ-DNMT1 in HCC. The present study well demonstrated that a comprehensive integrative informatics approach can be employed as an efficient screening stratagem to effectively extract worthwhile insights from a massive amount of complex, multidimensional molecular datasets.