مزاح سے متعلق اسلامی و مغربی مفکرین کی آراء اور نبوی ﷺتعلیمات ؛ایک تجزیاتی مطالعہ Views of Islamic & Western Scholars about Humour and Propheticﷺ Teachings; An Analytical Study

Fun and humour are part of human nature and character while people have a strong desire for relaxation that they want to have the means to express joy. Even bitter ideas can be easily conveyed to others through humor and good nature. Islam did not only allow laughter and entertainment but also prescribed such rules and regulations that people can fulfill their natural needs while living within the limitations. The Holy Prophet ﷺ made the best arrangements for Islamic state of Madina, the tastes and interests of the people, and their entertainment, and set an example for the rulers that like other countries. Hazrat Muhammad ﷺ did not only allow laughter and humor, but he himself was cheerful and happy towards his companions. Humour is an essential element of human life, and it has significant importance in Islam as well as in other religions. In this regard, we also get a lot of guidance from Sirat-e-Tayyaba, and it is justified with certain conditions. In this article, the authors have discussed the introduction of humor, its status in Shariah and its limitations from the perspective of Islamic Shari'ah. The authors have tried to analysis opinions of psychologists, Islamic and Western thinkers in this regard. Keywords: Cheerfulness, Humor, Human Instinct, Entertainment Humiliation.

Synthesis, Spectral Characterization and Biological Evaluation of 1, 3, 4-Oxadiazole and Morpholine Bearing Heterocycles

The presented research work in this dissertation comprises of synthesis, characterization, antimicrobial, hemolytic and enzyme inhibition studies of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches (scheme-1-11) were utilized to synthesize poly-functional compounds. In first scheme, twenty three 5-substituted-1,3,4-Oxadiazol-2-thiols were synthesized by converting multifarious organic acids consecutively into the corresponding esters and hydrazides. Further the intermolecular cyclization of various carbohydrazides with carbon disulfide and potassium hydroxide yielded subsequent 5- substituted-1,3,4-Oxadiazol-2-thiols. Moreover, the reaction of different 5- substituted-1,3,4-Oxadiazol-2-thiols (scheme-2 & 3) with electrophiles, 2-bromo-N- [4-(4-morpholinyl)phenyl]acetamide and 2-bromo-N-[2-(4-morpholinyl)phenyl] acetamide yielded thirteen, N-[4-(4-morpholinyl)phenyl]-2-[(5-aryl/aralkyl-1,3,4- Oxadiazol-2-yl)thio]acetamides and fourteen N-[2-(4-morpholinyl)phenyl]-2-[(5- aryl/aralkyl-1,3,4-oxadiazol-2-yl)thio]acetamides respectively in the presence of N,N- dimethylformamide and sodium hydride. Sixteen novel benzyl sulfides (scheme-4) bearing 1,3,4-oxadiazole moiety and sulfo- morpholine functionality were synthesized (bromomethyl)phenyl)sulfonyl)morpholine with by the different reaction of 4-(4- 5-substituted-1,3,4- Oxadiazole-2-thiols. Nucleophilic substitution reaction of free thiol group in 1,3,4- Oxadiazoles with 4-(2-chloroethyl)morpholine hydrochloride yielded thirteen, 4-[2- [[5-aryl/aralkyl-1,3,4-Oxadiazol-2-yl]thio]ethyl]morpholine derivatives (scheme-5) in the presence of acetone and potassium carbonate . A series of nineteen electrophiles (scheme-5), N-substituted-2-bromoacetamides was developed by the reaction of different substituted/unsubstituted aryl/aralkyl/alkyl amines with 2-bromoacetyl bromide by using DCM or basic aqueous medium as solvent. Seventy one (71) acetamides were synthesized by the reaction of 5-(2-chloro/3- chloro/4-chloro/4-nitrophenyl/phenyl)-1,3,4-Oxadiazol-2-thiols with different electrophiles by simple stirring in the presence of DMF solvent and NaH base at the room temperature. The structures of all the synthesized compounds were characterized by using IR, 1H- NMR and mass spectral data. In addition, 13C-NMR technique was also used in some cases to support the structural analysis. A rational mass fragmentation pattern of some of the compounds is also proposed. Some of the 1H-NMR, 13 C-NMR and EIMS spectra of synthesized compounds are also presented for the obvious perceptive of signals. The synthesized compounds were evaluated for antibacterial, antifungal, hemolytic and enzyme inhibition activities. Some of compounds were found to be active and showed interesting results in different studies declared above. The biological activity data in comparison of each scheme with the reference standard drugs is presented in biological activity section.