جو مہرباں تھے مرے اب وہ مہرباں نہ رہے
خفا کسی سے کبھی ایسے آسماں نہ رہے
جو وقت بدلا تو پھر لوگ بھی بدلنے لگے
جو راز داں تھے کبھی پھر وہ رازداں نہ رہے
ہر ایک شخص گیا ہٹ مقام سے اپنے
نہ پیر پیر رہے وہ جواں جواں نہ رہے
ستم ظریف نے کہہ کر یہ آگ لگوائی
کسی بھی طور مرا باقی آشیاں نہ رہے
وہ خوش نصیب ہے خوش بخت جس کا تائب جی
زمانہ لاکھ رہے یار بدگماں نہ رہے
The study investigated the relationship of the multiple intelligences of the Bachelor of Secondary Education students and their teachers in their major subjects. Four hundred eighty-five (485) BSED students and twenty-two (22) teachers in their respective major subjects participated. The result demonstrates statistically significant in the multiple intelligences of the Bachelors of Secondary Education Major in Technology and Livelihood Education and Music, Arts, Physical Education and Health and their teachers in their respective major subjects. However, result also demonstrates no significance in the multiple intelligences of the Bachelors of Secondary Education Major in Filipino, English, and Mathematics and their teachers in their respective major subjects. The study shows that the dominant intelligences of the BSED students and their teachers in their major subjects are the interpersonal, intrapersonal, and their suited intelligences for their major subjects. The result evidently showed that the BSED students and their major teachers are people and self smart. This only shows that as a teacher, one should know how to socialize appropriately with others and have a deeper understanding with themselves. It also showed that the teachers are really smarter than their students in their major field of specialization. Educators must also consider the multiple intelligences of their students to fully develop their learning capabilities.
This research work comprises of the synthesis of quinazoline derivatives and evaluation of their in vitro biological activities. The chemical structures of synthetic compounds were characterized by several spectroscopic techniques such as 1H-NMR, 13C-NMR, IR, EI-MS, and HREI-MS. Melting points and Rf values were also taken. This dissertation is divided into two chapters based on literature survey and research findings. Each chapter has its own compound numberings and references. Chapter 1 This chapter deals with the extensive literature survey on the heterocyclic compounds; especially quinazolines, their biological importance and synthetic protocols; several biological activities which were carried out on synthetic compounds; and research plan. Chapter 2 This chapter deals with the syntheses of compounds 3-27, 32-55, 59-82, 86-125, 129-155, 158, 161-184, 187-210, and 213-236 and evaluation of their various in vitro bioactivities. Compounds 4-7 and 9-27 were found to have several hundred folds better inhibitory potential against α-glucosidase, when compared to the standard drug, acarbose. For the β-glucuronidase inhibition, compounds 3-6, 10, 11, 13-17, 19-21, 23-27 showed better activity than the standard, D-saccharic acid 1,4-lactone. Compounds 5, 8, 10, 14, 17, and 19 selectively displayed thymidine phosphorylase inhibition. For xanthine oxidase inhibition, compound 13 showed the activity similar to the standard, allopurinol. Compound 19 showed better activity than the standard, EDTA against phosphodiesterase inhibition. Compounds 3, 17, 23, and 24 demonstrated weak inhibitory potential against carbonic anhydrase inhibition. Compounds 38 and 51 exhibited the best activity against leishmaniasis when compared to standard, pentamidine. Compounds 4, 6, 7, 12, 16, 17, 19, 59, 66, 74, 76, 78, and 80 showed weak activity for the pancreatic β-cell viability studies. Compounds 6, 13, and 25 showed excellent superoxide anion radical scavenging activity. Compounds 88, 91, 102, 103, 119, 133, 137, 144, and 153 were found to have better anti-inflammatory potential than the standard drug, ibuprofen. All synthetic compounds were found to be inactive for α-chymotrypsin, dipeptidyl peptidase, and urease inhibitions, and antiglycation studies.