ارادھنا
اے ربِ رحیم و کریم۔۔۔!
اِن اللہ علی کلِ شیئٍ قدیر!
میں خانہ بدوش ، سیلانی ، آوارہ!
تیری زمیں پر۔۔۔تیرے موسموں کے ساتھ محوِ سفر ہوں
تو کریم۔۔۔سبز موسم کا لباس پہن کر!
تو رحیم۔۔۔خوشبو کی طرح روح میں اُتر کر!
میرے تڑپتے سسکتے دل کو۔۔۔!
اپنی آغوش میں لے کر۔۔۔اپنے ہاتھوں سے سہلاتا ہے
دشتِ بیاباں میں دل فریب آہو بلا کر !
ستاروں کی سرگوشیوں میں!
نرم ٹھنڈی ریت پر سلا کر!
میرے خیالوں کے، حوالوں کی بدکتی ناقہ کو وحشتوں سے نجات دلاتا ہے
میرے تڑپتے سسکتے دل کو!
اپنی آغوش میں لے کر ، اپنے ہاتھوں سے سہلاتا ہے
تو ہی خالق۔۔۔ تو ہی مالک۔۔۔!
تیری کائنات میں اسرار جبرائیل ؑ کے ثبوت موجود ہیں
نیاز الہام اور قلب نامہ بری کے!
چراغ نور کی روشنی میں مظہر خلیلؑ کے ثبوت موجود ہیں
تو مجھے بزم رقص سے۔۔۔!
کوہ قبیس کی طرف لسان شعور کے لہجے میں بلاتا ہے
مسافتوں کے مارے دل کو!
اپنی آغوش میں لے کر، اپنے ہاتھوں سے سہلاتا ہے
تیری وجہ سے
لوح و قلم کو بھی ۔۔۔اپنے ہونے کا یقین ہے
تو ہی ’’وھو علی کل شی ئٍ قدیر۔۔۔وھو علی بِکل شی ئٍ علیم‘‘ ہے
صبح و شام میرے ارادوں کو۔۔۔تو اپنی پہچان کرواتا ہے
مسافتوں کے مارے دل کو!
اپنی آغوش میں لے کر ۔۔۔اپنے ہاتھوں سے سہلاتا ہے
The modern scientific concepts were clearly envisioned in the Qur'an date back to 7th century, when observational facilities were not available, mathematical principles were not discovered, primary principles (quarks) and fundamental forces i.e. Gravitational and electromagnetic were not identified. The word earth (أرْضَARD) appears 409 times in Quran. The number of verses in which the Earth is mentioned first is quite small, e.g. Sura 2, verse 29 and sura 20, verse 4, where a reference is made to "Him Who created the earth and the high heavens". On the other hand the numbers of verses where the Heavens are mentioned before the Earth are much larger e.g. Sura-l-araf (7), Verse 54; SuraYunus (10), verse 3; SuraQaf (50), verse 38; Sura l-Hadid (79), verses 27 to 33 etc. The Quran describes itself as a book of guidance. Sura l-Baqarah, verse (67)[i] states: قَالَ أعُوْذُ بِاللهِ اأنْ أَکُوْنَ مِنَ الْجَاهِلِيْن He said, "I seek refuge in Allah from being among the ignorant."The Qur'an does not render a coordinated description of the Earth Creation. In lieu of a continuous story of creation, there are verses dispersed all over the Quran which deal with certain aspects of the Earth Creation. These scattered verses provide information on the sequential events marking its development with varying degrees of detail. The Quran referred toward at least five points which shed light on the creation of heaven and earth. And these points are entirely confirmed by scientific facts.
Diabetic Nephropathy (DN) is a major complication of both type 1 and type 2 diabetes and a leading cause of mortality due to End Stage Renal Disease (ESRD) worldwide. This overwhelming clinical problem is also affecting a number of diabetic patients in Pakistan. Several molecular pathways could lead to the development of DN. In this thesis, the role of genes in one classical pathway, the Renin Angiotensin Aldosterone System (RAAS) along with fatty acid metabolism, and cardiovascular related pathways were investigated in type 2 diabetics, nephropathy and ESRD cohorts. The aim was to see the allele and genotype frequency differences of Pakistani, French and UK population. The study is divided into three parts for Pakistani, French and UK cohorts. For Pakistani Punjabi population, 206 subjects mainly from the Faisalabad district were included. The study design comprised of four groups which were analyzed for biochemical and molecular characterization. PCR and PCR-RFLP based genotyping assays followed by Real Time PCR technique (TaqMan Assay) were carried out for the ACE, AGT, CYP11B2 and ACACB genes to identify the genotypes of each group individually, and calculate and compare their genotype frequencies among four groups as well with individual non-genetic parameters in each group. The association of genotypes was analyzed for their correlation with all of the biochemical parameters, as well as with hypertension, family history of diabetes and nephropathy status. The results showed the association of CYP11B2 gene polymorphism (T/C) with diabetes with OR (95%CI, P value) of 3.20 (1.15-8.91, 0.02), and a significant association of ACACB gene polymorphism (G/A) with obesity/BMI (P =0.009) and type 2 diabetes (P=0.02). For French cohorts, one of the genes of fatty acid metabolism pathway i.e. ACACB (G/A) was analyzed in five different cohorts (n=7438) of diabetic patients who were at various stages of nephropathy. The genotypes were compared for ethnic variations as well as association for different parameters. Results showed a significant association (P=0.02) with ESRD. For UK population, the association study of cardiovascular and hypertension related SNPs in LPA, DAB2IP and TLL1 genes with baseline characteristics or disease outcomes in four UK cohorts (n=5602) was performed. Results showed LPA SNPs association with serum Lp(a) levels in one of the cohorts (NPHS-II group), whereas for DAB2IP SNP (rs7025486), the significant association with High Density Lipoprotein levels (P=0.01) and Diastolic Blood Pressure (P=0.03) was observed. From this study, it is suggested that if similar studies are carried out on large number of samples (replication and meta-analysis), it will be helpful in identifying genetic biomarkers for DN on the basis of ethnic variations and devising pharmacogenomics based interventions.