گزرتا ہے تو یہ گزرے بہار کا موسم
رہے مدام الٰہی یہ پیار کا موسم
کہاں گئی ہے وہ رُت تیری دید کی جاناں
جو دے گئی ہے مجھے انتظار کا موسم
ٹھہر گیا ہے غم و رنج میرے آنگن میں
کہاں گیا ہے سکون و قرار کا موسم
عجیب بات ہے یارو کہ اس بڑھاپے میں
ہے یاد آنے لگا کوئے یار کا موسم
میں دل کے زخم دکھائوں تو کس طرح تائبؔ
بتائوں کیسے دلِ داغ دار کا موسم
Teletherapy is an emerging and enlarging tool for having treatment in occupational therapy in rehabilitation sciences among occupational therapists all over the world mainly in Pakistan, especially during the era of COVID-19. A lot of studies have been done already highlighting the paramount of teletherapy around the world but it is a new rising mode of treatment in Pakistan coming to light. Therapists and Patients throughout the country making the most of this treatment way respectively and hence this method of treatment while using of technologies is highly being appreciated.
The aim of this study is to foster and encourage the use of this technology in third-world countries like Pakistan. It is the most used treatment tool during COVID-19 among occupational therapists all over the country and is highly appreciated in order to cut-down the negative circumstances of a one-to-one session in which therapist and patient is in highly close contact to each other. This course of action has advocate the on-going rehabilitation treatment and has kept away people from COVID-19 expansion to the most extent.
In this study, a 5years old boy was included with an under-diagnostic process within the umbrella term of genetic disorder. Having genetic disorder, his sessions were taken in tele-clinic using video call technology during COVID-19. In this process, AOTA Occupational Therapy Tele-Health Decision Guide, AOTA Occupational Profile Template, AOTA Advisory Opinion for the Ethics Commission Teletherapy, i-PiCS-Internet-Based Parent-Implemented Communication Strategies Program, and modeling strategy were followed.
In the present workpyrimido[5,4-c]quinoline-2,4(1H,3H)-diones (5-24) were synthesized by two step reaction sequence involving Knoevenagel condensation and Doebner Miller reaction. Compounds (5-24) were availed by fusion of Knoevenagel adducts (5benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione and 5-(3-nitrobenzylidene)pyrimidine2,4,6(1H,3H,5H)-trione) (3a-b) with anilines viz.sulfanilamide, 4-amino-N-(thiazol-2yl)benzenesulfonamide, sulfamethazine, sulfaguanidine, sulfamethoxazole, paminobenzoic acid, p-nitroaniline, 3-nitroaniline, 3-hydroxyaniline, p-phenylaniline, 5amino-2-hydroxybenzoic acid, 3-aminoacetophenone, 4-amino-2-hydroxybenzoic acid, 4aminoacetophenone and 4-chloroaniline (4a-o) in an oil bath at 170-265 oCafforded desired compounds in moderate to good yields (55-74%). All the compounds were tediously characterized. The prepared compounds (5-19) were tested for their in vitro antioxidant activity and at all instances they exhibited excellent activity in comparison to control Ascorbic acid. Compounds (20-24) were selectively screened for in vitro antibacterial and antiviral activities as these compounds has active pharmacophores in the structure. The most active compounds were 23, 21 and 22 having MIC 0.5, 1.25 and 1.75 µg respectively against P. vulgaris where ampicillin (MIC 2.25 µg) was employed as positive control. In case K. pneumonia compound 24 was found most active (MIC 0.1 µg) in comparison to control ampicillin (MIC 1.25 µg). In case of antiviral activity of the synthesized compounds (2024), compound (23) has expressed maximum in ovo antiviral potency against all four viruses (AIVH9N2, NDV, IBDV and IBV) with IC50 (0.001 µM). In case of synthesis of oxepines (38, 38´, 43 and 43´), a multi-step strategy (9 steps) is developed starting from 1-indanone anf finally the more polar compound 38 was dyrolysed to compound (40) to avail above mentioned compounds in respectable overall yield (0.39%).