عظیم شخصیات کے اوصاف وخصائص: سیرت طیبہ کی روشنی میں

Great lineage, good manners, trustworthiness, sincerity, courage and bravery, obedience, generosity, modesty, humility, thankfulness, absolute trust in Allah, education and upbringing, affection and compassion towards the elderly, the youth, slaves and animals, the regard for truth, the endurance and patience etc. Are such features that at them neither was the match for the Holy Master (saw) born, nor will any such person be ever born. In addition, let alone friends, his enemies were helpless to hold him as-Sadiq (the Truthful) and al-Ameen (the Trustworthy) due to these and many other great attributes; and they would say: Muhammad is not a liar at all, but we can’t believe in him as a prophet sent by Allah. Moreover, even a non-Muslim or polytheist has never criticized his character to this day, nor will anybody do till the judgment day. Whenever the greatest personalities of the world were listed or somebody committed to writing on the said topic, the Holy Prophet (saw) remained at the top of the list. Drawing of the swords of father and son against each other, the change of the standard of friendship and enmity, fighting of master and his slave against each other, chanting the slogan of Ahad-Ahad (the only One, the only One) on the blazing sand, giving priority to martyrdom over the utterance of a word of unbelief, taking a husband away from his wife and separating a mother from her infant, deforming the condition after a blasphemous blow on the blessed face, forced migration to Habsha (Abyssinia) at times, and laying siege to Shb-e-Abi Talib (the valley of Abi Talib) at times.

In-Vivo Study of Acute Liver Injury Induction Potential of Anti-Psychotic Drugs

Liver is an essential organ that controls around various physiological functions such as production of bile, plasma proteins, and hormones aids in digestion and detoxification of drugs as well. Drug induced liver injury (DILI) is the principal cause of acute liver failure (ALF) in various countries. There is a broad array of anti-psychotic drugs (APDs) which are used to treat bipolar disorders most commonly schizophrenia and other neuro-psychotic disorders. One of the two famous anti-psychotic agents; aripiprazole and ziprasidone belong to atypical class of anti-psychotics. Although APDs are currently being used all over the world yet these drugs have displayed many side effects. In-vivo estimation of acute liver injury level by APDs therefore bears significance so as to determine the efficacy and identify potential health hazards. Current study will determine the liver injury induction potential of APDs in animal model.To induce acute liver injury, acetaminophen (APAP) was used. The foremost drug responsible for DILI is APAP which induces oxidative stress and dysfunction of mitochondria. Collection of blood samples was done in aseptic conditions, and collected serum was subjected to biochemical estimations. Serum ALP and ALT levels has been assessed to determine the effect of APDs on liver functioning efficiency. Estimation of serum ferritin has provided iron storage estimation. Moreover, the study had also evaluated the renal efficiency changes induced by APDs via estimation of urea and creatinine levels. HDL, LDL, TG and cholesterol levels were also estimated to identify the effect of these drugs on lipid profile. Thus, the study will provide a rationale for the utilization of APDs and their effects on a body system, in comparison to APAP induced acute liver injury.