انتظار
ماں ۔۔۔ !تم نے کہا تھا
بابا آسماں پر سیر کو گئے ہیں
کل آئیں گے
میں اس کل ہی کے انتظار میں بسمل ہو گیا ہوں
اے ماں! تو بھی کہہ بابا سے
’’اب لو ٹ بھی آئیں ‘‘
ان کی انگلی تھامے بنا
اب چلنا مشکل ہو گیا ہے
Hazrat Maulana Syed Zawwar Hussain Shah is the knowledgeable and spiritual personality of the fourteenth century Hijra. There are diverse aspects of his qualities and perfections. A matchless diversity can easily be found in his services related to his scholarly work and reformation of Muslim Ummah. Not only a Translator, Biographer or Poet but he, at the same time, was also an expert of Islamic Jurisprudence and held the position of a Sheikh of Islamic Sufi order of Naqshbandi Mujaddiah. Shah Sahib authored and compiled 13 books. The study of translated works ( Mabda wa Ma’ad, Muarif-e-Ludniya, Maktoobat-e-Masoomia, Maktoobat Imam Rabbani) of Shah Sahib's and discussion on its importance is the prime focus of this article.
In the present work three series of Mannich bases of 1,3,4-oxadiazole-2(3H)-thione (121170) have been successfully synthesized with good to excellent yield and comprehensively characterized by FTIR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Furthermore, their in-Silico and in-vitro evaluation showed them as excellent urease inhibitors which were even better than standard. All the synthesized compounds were also evaluated for their antioxidant properties as well as antiviral activities against the four poultry viruses (IBA, H9N2 , NDV, and IBDV). The synthetic strategy for the synthesis of these Mannich base derivatives are as under. Synthesis and Biological evaluation of pyrazinyl based derivatives (119-135) The strategy for the synthesis of targeted compounds is elaborated in Scheme 29. Ethyl pyrazine-2-carboxylate (119) was prepared by the esterification of pyrazine-2-carboxylic acid (118), which was further converted into pyrazine-2-carbohydrazide (120) by refluxing with 80% hydrazine hydrate in ethanol. The synthesized hydrazide underwent cyclization to yield 5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione (121) upon reacting with CS2 in alkaline medium. Which was then further converted to respective Mannich bases 3-[{(substituted phenyl)amino}methyl]-5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione or 5-(pyrazin-2-yl)-3[{(substitutedpyridin-4-yl)amino}methyl]-1,3,4-oxadiazole-2-thione (122-135).