مولانا محمد جعفر شاہ پھلواروی
مولانا محمد جعفر شاہ، پھلواروی شریف(بہار)کے ایک نامی گرامی خانوادۂ علم و تصوف کے چشم وچراغ تھے، ندوۃ العلماء لکھنؤ میں تعلیم پائی تھی، فراغت کے بعد ادھر اُدھر رہے۔ آخرپاکستان گورنمنٹ کی سرپرستی میں لاہور میں ادارۂ ثقافت اسلامیہ قائم ہوا تومولانا اس سے ایسے وابستہ ہوئے کہ عمر وہیں گزار دی۔ اس دور میں انھوں نے’’المعارف‘‘میں مقالات لکھے اور متعدد اہم اورفکرانگیز کتابیں بھی تصنیف کیں۔ ان کی کتاب’’اسلام اورموسیقی‘‘اورمسائل اجتہادیہ پربعض حلقوں میں کافی شورش ہوئی لیکن مرحوم کے موقف میں کوئی تبدیلی پیدا نہیں ہوئی۔ان کی علمی استعداد پختہ تھی، مطالعہ وسیع تھا، طبیعت غوروفکر کی عادی تھی اور ان کا جوہر ذہانت وطباعی خداداد اورفطری تھا۔۱۹۶۹ء اور۱۹۷۶ء میں ان سے لاہور میں متعدد ملاقاتیں ہوئیں، جب کبھی ملے توبڑے تپاک اورمحبت سے ملے، ایک مرتبہ گھر پر مدعو بھی کیا۔ میں نے ہمیشہ یہ محسوس کیا کہ مرحوم اپنی تحریروں کے آئینہ میں جس قدر آزاد خیال نظرآتے ہیں، عقیدہ و عمل اوراخلاق وشمائل کے اعتبار سے اسی درجہ کے پکے اورسچے مسلمان اور عالم باعمل تھے۔ ادارۂ ثقافت اسلامیہ لاہور سے سبکدوش ہونے کے بعد وہ لاہور سے کراچی میں سکونت پذیر اورگوشہ نشین ہوگئے تھے۔اللھم اغفرلھماوارحمھما [جولائی۱۹۸۲ء]
The article titled: the rights of foetus in Islamic law, aims at explaining the rights of foetus without discussing different theories of the scholars in this regards. It also defines the foetus and gives literal and technical meanings besides different stages of foetus mentioned in the Holy Quran and the Hadith. The article explains the rights granted to foetus in the lights of serah before birth and these rights are a binding on the concerned people and violation of foetus’ s rights is prohibited and it is a cognizable offence. The article also discusses the attitude of west regarding foetus rights as the western society is totally ignorant about the rights of foetus and their legislation in this regard is contrary and several western laws are causing the violation of foetus’s rights. Thus, the champions of human’s rights are blind to the rights of foetus which is foundation and beginning of human life and first step for the human race. It is that has given these rights to mankind for the first time and informed human being about their rights through the first human’s rights charter given at the time of the Noble Prophet {blessing of Allah and peace be upon him}. This charter is known as the charter of Madina between the Muslims and the Jews. The article concludes: mankind cannot be protected unless the sperm of man is protected and foetus is protected in the womb of the mother from abortion because these are the future of humanity.
Background: Nearly one-third of the global population, i.e. two billion people, is infected with Mycobacterium tuberculosis and is at risk of developing the disease. More than eight million people develop active tuberculosis (TB) every year, with about two million dying from the disease annually. Diagnosis of tuberculosis inKenya remains dependent on smear microscopy. New methods of TB diagnosis are needed which have better accuracy and are still cost effective. Molecular methods of TB diagnosis have come under investigation in a lot of studies recently. However, they have their own limitations including the inability to differentiate between active organisms and dead bacilli in specimens.
Aim: To determine the sensitivity and specificity of the Genotype® MTBDRplus assay in the detection of resistance to Isoniazid and Rifampicin in mycobacterium tuberculosis isolates.
Materials and methods: This is a descriptive and comparative study in which the performance of a new laboratory assay will be compared to the existing (reference) method. All sputum specimens submitted for TB culture and sensitivity to the Aga Khan University Hospital Laboratory microbiology section during the period from August 2008 – April 2009 were included in the study. All sputum specimens submitted underwent smear microscopy, culture and sensitivity testing by the MGIT 960 system and DNA extraction and Genotype MTBDRplus assay for both the direct specimen as well the positive culture tube.
Results: 202 sputum specimens were included in the study. Valid phenotypic DST results were obtained for 135 cultures (68%). The number of strains resistant toRIF and INH was 4.5%, 14% respectively. Valid GenoType® MTBDRplus assay results were obtained for 116 DNA extracts (86%).
Sensitivity and specificity of the test for the detection of Isoniazid resistance were 0.68 (95% CI: 0.43 - 0.87) and 0.99 (95% CI: 0.95 - 0.99) respectively. Sensitivity and specificity of the test for the detection Rifampicin resistance was 0.78 (95% CI: 0.40 - 0.97) and 0.99 (95% CI: 0.96 - 1.00) respectively.
Comparative analysis demonstrated scientifically acceptable overall agreement between molecular (sputum specimens) and phenotypic DST results as shown below (Cohen’s Kappa = 0.76 (95% CI: 0.59 - 0.93) for Isoniazid resistance and Cohen’s Kappa = 0.81 (95% CI: 0.60 - 1.02) for Rifampicin resistance
Conclusions: The Genotype MTBDRplus assay demonstrated acceptable sensitivity and specificity for use in laboratory diagnosis of Tuberculosis and the detection of drug resistance.