سنتو رانی
بیل گاڑی پہ بیٹھی سنتو،پستان سے اپنے ننھا لٹکائے
کچی سڑک پر دھول جگاتی، بیل گاڑی بھگاتی جائے
گہری سوچ میں ڈوبی
دور آسمانوں میں تکتی
کبھی کبھی درانتی سے سر کو کھجاتی
ہوا کو دکھڑے سناتی
’’رُلدو کا بابا، میرا پریمی
نجانے کس دیس چلا گیا
جہاں سے سندیس بھی نہ آوے
یہ کیسی پرکشا ہے رادھا دیوی!
Molana Shah Hakeem Mohammad Akhter was born in 1923 in Partabgarh UP India. He received Medical Education from Unani Medical College Ellah Abad and Islamic Education under a great saint Shah Abdul Ghani Phoolpuri in Madrasa Bait ul Aloom. He was a born Sofi, an eminent Islamic scholar, a great philanthropist, an established writer and a great reformer. He wrote more than 200 books. He also established an Islamic University, Asharaf ul Madaris. Thousands of scholars are his pupils, followers and disciples. He imparted them both Aloom-e-Shareyat and Tareeqat. In 2001 he founded an Islamic NGO naming “Al-Akhtar trust International” for helping the suffering humanity. During these days society was ridden with un-Islamic trends and practices Shah Hakeem Mohammad Akhter emerged to rooted out these evils from the society. It will not be wrong to say that Shah Hakeem Mohammad Akhter like his spiritu-al mentor (Maulana Ashraf Ali Thanvi) was the real inherent of Ulama-e-deoband. The aim of this article is to present over view of biography and invalua-ble services which he rendered for tasawwuf and noble cause of humanity.
S. pyogenes or Group A streptococci (GAS) is a notorious and significant human pathogen. S. pyogenes infections broadly range from superficial skin infections, and noninvasive infections (pharyngitis, scarlet fever) to life threatening invasive infections like streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF). Such infections are often followed by post-streptococcal sequelae, including rheumatic heart disease and acute glomerulonephritis. Among other beta hemolytic streptococcal groups, group D streptococci (GDS) are the frequent cause of hospital-acquired urinary tract infections and bacteremia. S. agalactiae or GBS is a leading cause of infections among pregnant women and neonates, whereas Group C and G streptococci are recognized as the emerging pathogens. S. pyogenes possess a number of cell associated (M protein, F protein, hyaluronic acid, lipoteichoic acid) and secreted virulence factors including streptococcal pyrogenic exotoxins (Spe), Streptolysin S and O, C5a peptidase, DNase and streptococcal inhibitor of complement responsible for the variety of infections. Particularly, M protein and Spe, exhibiting superantigenic activity (SAg) are considered as the major virulence factors of S. pyogenes. M protein, encoded by emm gene serves an important surveillance tool to monitor GAS diversity, epidemiology, disease patterns, dynamics of transmission and formulation of indigenous vaccine. SAgs are low molecular weight, highly potent extracellular products, usually associated with severity of infections. However, to our knowledge no data is available from Pakistan regarding the prevalent emm types and SAgs genes distribution. Therefore, this study was designed to monitor the prevalence and epidemiology of β-hemolytic streptococci, antibiotic resistance pattern, molecular mechanism of drug resistance, emm genotypes and superantigens profile in Pakistan. Hence this would be the first comprehensive report about GAS epidemiology, chemotherapy and pathogenesis from Pakistan. This study would further help us in understanding the possible links among invasive and noninvasive streptococcal diseases with emm types and superantigens.