فلمیریا
پرانی اکھان اے بھئی گدڑ دی موٹ آوے تے اوہ شہر ول نسدا اے۔ خورے ایہو گل سی یاں کجھ ہور اک رات روٹی ٹکر توں بعد ساڈی مطالعے دی حس اچن چیتی جاگ کھلوتی رات دے ویلے سارے لوکی سوندے نیں ایس لئی سانوں ایس حس دے جاگن تے ڈاڈھی حیرانی ہوئی۔ بہوں تھپیاں تے لوریاں دیتاں پر ایہہ کالے ناگ وانگوں شوکراں مار دی ای رہی۔ اخیر سانوں تاکڑی وچہ لمیاں پیئاں کتاباں وچوں اک کتاب نوں تکلیف دینی پئی۔ کتاب دا گھٹا جھاڑ کے دوچار ورقے پھرولے تے ساڈی نظراں اک مضمون نوں گھٹ کے انج جپھا پالیا جویں کوڑ کرلی چھیتر نوں پاندی اے اجے دوچار سطراں ای پڑھیاں سن کہ اچن چیتی سادی نظراں ایہناں شبداں تے چاٹی اُتے مکھن وانگر جم گئیاں۔ لکھیا ہویا سی ’’دنیا اک سٹیج اے تے ایس جگ دے سارے بندے ایہدے کردار۔ اک دیہاڑے پردہ ڈگ پوسی تے فیر ۔۔۔۔۔‘‘ تے فیر ایس توں اگلا منظر اسیں ویکھنا وی نئیں چاہندے ساں۔ ساڈی دلچسپی تے بس ایتھے تیکر ای سی۔ کتاب دی پوتھی اپنا کم وکھا چکی سی۔ مطلب ایہہ بھئی ساڈی مطالعے آلی حس خراٹے خراٹا پئی لیندی سی۔
جد اساں آپ خراٹے لین لئی منجی اتے لمے پئے تاں خورے کتھوں ساڈے دل، دماغ، کلیجی، گردیاں، پھیپھریاں تے آندراں اک جلوس دی شکل وچہ ساڈے اگے گھیرا پالیا۔ ایہہ جلوس نعرے لالا کے سانوں طعنے معنے ماررہیا سی پئی جگ وچہ آکے ہن تیکر کجھ نئیں کھٹیا۔ اوڑک اساں ایہہ سوچن تے مجبورہوگئے جو ایہہ دنیا اک اسٹیج اے تے جگ دے لوکی ایہدے کردار۔ مطلب ایہہ پئی اسیں سارے اداکار آں۔ ایہہ سوچدیاں ای اساں اک لمی تاری لائی تے تخیل دے دریا وچ ڈونگیاں ڈونگیاں ٹوبیاں مارن...
Background: Chronic hepatitis C infection has created a huge burden of disease causing serious health effects. The combination therapy used to treat hepatitis C virus (HCV) infection includes Pegylated interferon and Ribavirin. As cholesterol biosynthesis plays a pivotal role in HCV replication, the use of various statins has been associated with higher sustained viral response Objective: To compare the efficacy of atorvastatin plus pegylated interferon and ribavirin versus pegylated interferon and ribavirin alone in patients of chronic hepatitis C with genotype-3a Methods: This Randomized controlled trial was conducted at outpatient department, Mayo Hospital Lahore for six months i.e. May to November 2017. After ethical approval, 60patients of ages 25 to 55 years of either gender with chronic hepatitis C with genotype 3a were included in the study. Informed consent was taken from all patients. Then patients were randomly allocated into two groups “A” and “B” using random number table. Patients in Group A received standard of care treatment for chronic hepatitis C i.e. Pegylated interferon and ribavirin while the patients in Group B also received tab atorvastatin along with the standard treatment. Patients were follow up for 4 week. Blood samples were collected and HCV RNA detection. All this information were entered in proformaResults: In standard therapy group, the mean age of patients was 39.50±8.39years. In atorvastatin plus standard therapy group, the mean age of patients was 34.30±6.78years. In standard therapy group, there were 25 (83.3%) males and 5 (16.7%) females. In atorvastatin plus standard therapy group, there were 16 (53.3%) males and 14 (46.7%) females. After 4 weeks, Rapid VirologicalResponse (RVR) was achieved in 4 (13.3%) patients in standard therapy group while in 14 (46.7%) in atorvastatin plus standard therapy group. The difference was significant (p<0.05) Conclusions: Atorvastatin in combination with Pegylated interferon and ribavirin have better efficacy as compared toPegylated interferon & ribavirin alone in chronic hepatitis C-3a.
There are several natural biological products, which are effective to trigger immune responses in animals and human beings. In this regard, various plant species are considered to be potent natural biological products and their efficacy has been reported in various animal models. In the present study, Aloe (A.) vera derived biomolecules including polysaccharides and proteins were isolated and characterized as biological response modifiers and their subsequent protective effects against coccidiosis in chickens. A total of 640 chicks were randomly divided into two main treatment groups namely A (polysaccharides) and B (proteins), each containing 320 chicks. Each group was administered orally with the graded doses of polysaccharides and proteins for three consecutive days i.e. day 5th, 6th and 7th of age. Cellular immune responses were assessed for in vivo and in vitro lymphoproliferative responses to Phytohemagglutinin-P (PHA-P), Concanavalin-A (Con-A) respectively and Carbon particle clearance assay. Humoral immune responses were detected by microplate haemagglutination assay on 7th and 14th days post primary and secondary injections of sheep red blood cells. Weekly weight gains and feed conversion ratios were also calculated. For therapeutic studies chickens were challenged with mixed Eimeria species on 14th day post administration of A. vera biomolecules. Results revealed significantly higher (p<0.05) lymphoproliferative response to PHA-P and Con-A in chickens administered with A. vera biomolecules as compared to control. Carbon particle clearance assay showed significantly higher clearance index (K) in control group than all biomolecules administered groups and phagocytic index (α) showed significantly higher response in all three biomolecules administered groups as compared to control. Significantly higher total Igs, IgG and IgM titers were also detected in groups administered with A. vera biomolecules. Biomolecules administered chickens showed better feed conversion ratios and significantly higher (p<0.05) weekly weight gains as compared to control. In challenge experiment maximum protection 70% and 57.5% were observed in polysaccharides and proteins administered groups, respectively. Significantly lower oocysts per gram of droppings, lesser lesion scores, better weight gains and higher anticoccidial index were observed in biomolecules administered groups. From the current study, it was concluded that A. vera derived biomolecules have the potential to be used as immunotherapeutic agent(s) in poultry and can be commercialized.