فیملی بزنس میں'' ابہام'' سے پیدا ہونے والے مسائل کا شرعی و تحقیقی جائزہ

ABSTRACTFamily Business is a very important form of business in this era and especially because of this it merely does not matter the business, but more sensitivity is of close relatives and relationships. That is why it has many administrative, Shariah and ethical complications. That is why, this theme has been created as a field of discussion and research. If the issues of Family Business are reviewed, their root is to leave the matters undefined, uncleared and undocumented. Then the solution to all these issues is to overcome their ‘Unclarity’ found in different aspects. To finish the matter, we should clear and correct for example ‘business status’ between father and sons, uncle and nephew or a few brothers. Similarly, in case of death of elders, the inheritance is to be determined. Then that all the matters should be written in a very brief manner and arranged. It is also possible to calculate the income and expenditure account. It is not appropriate that every partner should spend without any speculation. Then one time it becomes difficult to face each other. In this article, we have tried to review all the dimensions where there may be more problems due to ‘unclearity’ in mutual business dealings. In this context, the first business status of family members has been explained. Then mentioned the problems raised after the death of the family leader. Later on, more aspects of the problem are presented by presenting some other observation examples on this subject.

The Role of Inflammation in Contrast Induced Nephropathy

Background: Intravenously administered iodinated contrast media are widely and liberally used in daily diagnostic radiological investigations. Contrast-induced nephropathy (CIN) is notable as the third commonest cause of hospital-acquired renal injury. Justification: The global prevalence of CIN from various studies ranges from 2-5% but an incidence of CIN of 12-14% in Kenya was highlighted by a recent study without an explanation for the markedly increased incidence. Intravascular contrast has been demonstrated to commonly cause renal vasoconstriction. However, the low incidence of CIN in the general population infers that contrast alone cannot be a causative insult. This study proposes that inflammatory states, which are prothrombotic, when coupled with renal vasoconstriction may confer a higher relative risk for development of CIN. Objective: To determine the risk of developing CIN given the presence of an inflammatory state in patients presenting to a private university hospital in Kenya. Study design: Prospective cohort study of patients undergoing a contrast- enhanced CT scan (CECT) in Aga Khan University Hospital, Nairobi (AKUHN) Radiology department and who have no known risk factors for CIN. Methodology: A total of 423 patients were recruited over a period of 4 months. The patients were grouped into those without inflammation (unexposed) having serum C-reactive protein (CRP) levels ≤5mg/dL and those with inflammation(exposed) having CRP levels >5mg/dl. Serum creatinine (SCr) was measured before the CECT and 48 hours following the CECT with CIN diagnosed when there was an increase of >25% in the SCr from the baseline value. Relative risk was determined and multiple logistic regression analysis performed on the biophysical variables (age, weight, sex) and contrast volume to assess their effect on development of CIN. Results: CIN was present in 42 (9.92%) patients. Of the exposed group (elevated CRP), 29 out of 215 patients (13.5%) developed CIN. In the unexposed group, 13 out of 208 patients (6.25%) developed CIN. This gave arelative risk of developing CIN of 2.16(1.15 to 4.04, P=0.016).The attributable risk percentage is 7.24% (1.1% to 12.2%). No statistically significant association was seen between the biophysical variables and volume of contrast and development of CIN. Conclusion: Inflammation doubles the likelihood of development of CIN. Therefore a patient presenting with inflammation and any other risk factor for CIN should have a risk-benefit analysis to assess the need for administration of iodinated intravenous contrast.