Human Papilloma Virus Related Head and Neck Squamous Cell Carcinoma-an updated review

Human papilloma virus (HPV) related head and neck squamous cell cancer (HNSCC) has varying etiology, genetic as well as environmental factors involved and differential clinicicopathological features. HNSCC came in the limelight recently due to increased incidence rate and insufficient diagnostic methods. This review will comprehensively focus on the characteristics of HPV associated HNSCC.  It will provide an updated review of our understanding of HPV role in Oral squamous cell carcinoma (OSCC) known to date. Curruntly, three vaccines are available (Gardasil, Gardasil 9 and Cervarix). These vaccines prevent infections with HPV types 16 and 18 HPV-16 is most common type associated with HNSCC. HPV related HNSCC has better prognosis, does not mutate  but inactivatestumor suppressor genes and therefore has comparatively better treatment options. However, there is still a need to improve our methods of sampling, HPV molecular assay and type of specimen to be used.

Towards Energy Harvesting and Congestion Control in Routing Protocols Design of Underwater Sensor Networks

The most significant issues in Underwater Sensor Networks (UWSNs) is to develop such power aware and energy efficient schemes which enhance the network life-time and also limit the usage of energy in net data transmission. This dissertation presents two routing protocols for UWSNs which are compared with the previously designed schemes. In the first scenario, we have proposed a routing protocol called Energy Harvesting in UWSNs (EH-UWSNs). This protocol proves to be a compact, energy proficient and high throughput routing scheme for UWSNs. In this proposed protocol architecture, we present Energy Harvesting with the cooperative transmission of data packets utilizing relay sensors. Through Energy Harvesting, the sensors recharge their batteries from the environment and forward information utilizing cooperation procedure, limiting power usage along-with reliable data delivery. At the final receiving node, the combining approach used is based on Signal-to-Noise Ratio (SNR). Simulation results of EH-UWSNs scheme indicate better outcomes in terms of energy consumption, end-to-end delay and network lifetime in contrast with the Co-UWSNs routing protocol. EHUWSNs have expanded substantially less energy when contrasted with Co-UWSNs along-with the information transmission. Also there is an intense need to design an optimized congestion control scheme which enhances the network life time and also controls the congestion of data packets. The second scheme which we have presented is called Dist-Coop (Distributed Cooperation with Towards energy harvesting and congestion control in routing protocols design of Underwater Sensor Networks by Malik Taimur Ali Page 2 Congestion Control) in UWSNs. It is a cooperation-based scheme which uses mechanism for optimized congestion control in noisy links of underwater. It is compact, energy proficient and high throughput opportunistic. The proposed scheme in this architecture is then compared with an existing scheme SPARCO and with our previously presented scheme EH-UWSNs. In literature, no such scheme existed which worked collectively on congestion control as well as energy consumption. Hence, the Dist-Coop protocol gave us promising results than previous schemes.