PHYSICAL THERAPY TREATMENT IN POSTNATAL WOMEN

Background: The postnatal period starts at the time when a mother gives birth to a baby; all changes that occur during pregnancy come back to a normal state like hormonal levels, size of the uterus, and weight. According to WHO this is the most ignorant period for postnatal women and their children by the society which is a bitter reality that’s why death is common in many mothers and children during the postnatal period. In Physical therapy, Gynecological rehabilitation is an important part of treatment and also a topic of consideration for referrals to doctors in the postnatal period to improve the issues related to postnatal women. Objective: To enhance the knowledge regarding the role of Physical therapy in the postnatal period of women. Search Strategy: This is a review article with extracts from various search engines like PubMed, CDC, MP, MCHI, Google scholar, Sci-Hub, etc. It is used to increase the knowledge regarding various treatment options in physical therapy that are helpful for postnatal women without causing side effects. Conclusion: Physical therapy consists of many interventions that can be beneficial, and it improves the quality of life of postnatal women.

A Co-Relation Study of Telomere Length and Genetic Predisposition to Acute Lymphoblastic Leukemia Among Pakistani Population

Acute lymphoblastic leukemia (ALL) is a hematological malignancy common in children and adult males. ALL is considered to be on the rise in Pakistan. External, physiological and genetic factors have been found to play a fundamental role in causing the cancer. In the present study, we investigated the external factors like exposure to radiations, chemicals, sunlight, smoking, electronic devices and dietary habits as potential risk factors in relation to ALL. None of these factors were found to be associated with ALL risk in Pakistani population. However, among physiological factors we found significant correlation between psychological stress and ALL incidence. Overrepresentation of B+ve blood group was noted among ALL patients. Replicative potential, telomere modulation, migration / metastasis, unlimited proliferation and metabolic reprogramming are important for tumor development. Genes including GMFG, EpCAM, PCSK9, CTC1 and OBFC1 were studied at transcriptional level to elucidate their role in ALL related to motility, proliferation, lipid metabolism and telomere modulation, respectively. The role of these genes in relation to ALL was not studied before. To study telomere modulation important for leukemia cell survival, telomere length measurement was performed. No significant changes in telomere length were observed. However, at transcriptional level, induced expression of telomere modulating genes (CTC1, OBFC1, hTERT) in ALL patients was observed which could be correlated with telomere length maintenance in leukemia cells. The induced GMFG expression, which is important for cell migration, in leukemia patients indicated that it has potential to be used as a leukemia diagnostic marker. EpCAM related to cell proliferation was not well established in ALL. Its mRNA expression was significantly upregulated in ALL patients. Similarly, PCSK9 which regulates cholesterol metabolism was also induced in ALL. mRNA expression of ALL specific genes like TAL1, BLNK and BLACE were also investigated and found to be upregulated in ALL Pakistani population. They, therefore, could potentially be used as ALL gene markers for early detection and diagnosis of leukemia. xii Next, in in vitro studies, naturally occurring biomolecules like costunolide and eugenol were used for identification of new therapeutic approaches with better treatment outcome. Costunolide, a potent telomerase inhibitor reduced EpCAM and its downstream target gene c-Myc and probably also contributed in inhibiting hTERT expression. Similarly, PCSK9 and LOX1 were significantly down-regulated by antioxidant eugenol. Results from this study suggested that costunolide and eugenol could plausibly be used as therapeutic biomolecules for reducing cancer cell proliferation and growth by limiting the metabolic supply.