مولانا حافظ عبدالعزیز
یہ سطور ابھی زیر تحریر ہی تھیں کہ جامعہ اشرفیہ مبارکپور کے سربراہ اعلیٰ مولانا حافظ عبدالعزیز کی وفات کی اطلاع ملی ان کی عمر اسی سال سے متجادز تھی، مگر ابھی خیال نہ تھا کہ وقت موعود اتنا قریب آچکا ہے، وہ بریلوی مدرسۂ فکر سے تعلق رکھتے تھے، مگر مزاج میں اتنا اعتدال تھا کہ دوسرے حلقہ کے لوگوں سے بھی خندہ پیشانی اور فراخ دلی سے ملتے تھے، علمی مشاغل کے ساتھ عبادت وریاضت سے بھی خاص شغف تھا، راقم الحروف نے ۱۹۶۸ء کے موسم حج میں ہندوستانی سفارت خانہ کی ایک تقریب میں پہلی بار انھیں دیکھا تھا، اور ان کی سادگی، احتیاط، اور زاہدانہ زندگی سے متاثر ہوا تھا، اﷲ تعالیٰ ان کے ساتھ رحمت و مغفرت فرمائے، اور ان کے اہل و عیال اور عقیدت مندوں کو صبر جمیل اور دین و ملت کی پر خلوص خدمت کی توفیق عطا فرمائے۔ (’’ع ۔ق‘‘، جون ۱۹۷۶ء)یہ سطور ابھی زیر تحریر ہی تھیں کہ جامعہ اشرفیہ مبارکپور کے سربراہ اعلیٰ مولانا حافظ عبدالعزیز کی وفات کی اطلاع ملی ان کی عمر اسی سال سے متجادز تھی، مگر ابھی خیال نہ تھا کہ وقت موعود اتنا قریب آچکا ہے، وہ بریلوی مدرسۂ فکر سے تعلق رکھتے تھے، مگر مزاج میں اتنا اعتدال تھا کہ دوسرے حلقہ کے لوگوں سے بھی خندہ پیشانی اور فراخ دلی سے ملتے تھے، علمی مشاغل کے ساتھ عبادت وریاضت سے بھی خاص شغف تھا، راقم الحروف نے ۱۹۶۸ء کے موسم حج میں ہندوستانی سفارت خانہ کی ایک تقریب میں پہلی بار انھیں دیکھا تھا، اور ان کی سادگی، احتیاط، اور زاہدانہ زندگی سے متاثر ہوا تھا، اﷲ تعالیٰ ان کے ساتھ رحمت و مغفرت فرمائے، اور ان کے اہل و عیال اور عقیدت مندوں کو صبر جمیل اور دین و ملت کی پر خلوص خدمت کی...
The History revealed the fact that merchants played a very prominent and vital role in spreading the religion of Islam. Prophet Muhammad (PBUH) remained one of the popular merchants of his time in the Arabian Peninsula. Similarly, the same profession was also adopted by the Prophet’s companions and they propagated the message of Islam almost in every corner of the world being a core mission of their lives. The number of Islamic countries on the world’s map witness their efforts in this regard. There are numerous sayings of the Prophet (PBUH) in which he praised the honest and truthful traders and cautioned with serious wrath for the otherwise. Keeping in view the contemporary scenario of corporate world, one can easily observe the lacking of professional and ethical values among the merchants more specifically concerned with commercialization and marketing. In fact, marketing is one of the sound sources to promote business but some companies try to exploit their consumers via fake commercialization and false advertising. Pakistan, being an Islamic country, has to devise such principles and regulations regarding commercial advertising which are in full conformity with Shariah standards that will definitely, secure the rights of all stakeholders along with fine attraction for foreign investment to put the economy on growing direction. The current paper deals with the morals and values of advertising in the light of Prophetic teaching.
Liver is a principal organ that preserves the homeostasis of human body and performs many other functions including; detoxification of drugs, storing glycogen, regulating cholesterol and metabolism of urea. Liver injury induced by drugs is still a critical obstacle in the successful development of medicines. Acetaminophen (APAP) is an extensively consumed pain killer and is also the main cause of Drug Induced Liver Injury (DILI). An established biomarker for analyzing liver injury at molecular level is Cytochrome-P450 2E1 (CYP2E1) enzyme, mostly associated with the acetaminophen hepatotoxicity. Thus, a safer more reliable and economical way to deal with DILI is to determine an alternative use of the approved drugs. Binding of adrenergic ligands with their particular receptors is prevented by alpha-adrenergic blockers and is used in treating benign prostatic hyperplasia, cardiovascular disorders and erectile dysfunction. In this current proposal we have investigated whether terazosin (TER), an alpha adrenergic blocker, is effective as a hepatoprotective agent in an acetaminophen induced acute liver injury induced animal model. White New Zealand rabbits were used as animal models and were given an oral dose of acetaminophen to induce acute liver injury. It was observed that the Adenosine triphosphate (ALT) and Alkaline phosphatase (ALP) levels were much reduced by TER. ALT results showed statistical significance when compared with APAP alone. The serum ferritin level result was found to be decreased following the APAP intake. Lipid profile was much improved by TER as it decreased the level of Triglycerides (TG), Total Cholesterol (TC), Total Lipids (TL) and Low Density Lipoproteins (LDL) and increased the level of High Density Lipoproteins (HDL). TG level was statistically significant when comparing CON with both APAP and TER. Urea and creatinine level was also reduced indicating that TER acts as renal efficient agent. As CYP2E1 is upregulated during liver injury, it was observed that TER downregulated the expression level of CYP2E1. Hence, it can be stated that TER is not only safer for arterial hypertension but it is safe for human consumption. TER showed prevention of acute liver injury that was caused by acetaminophen, thus further studies can strengthen its alternative use in hepatoprotection.