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Formulation and Evaluation of Press Coated Tablets of Piroxicam and Sucralfate

Thesis Info

Author

Ata Ur Rehman

Supervisor

Muhammad Imran Khan

Program

MS

Institute

Riphah International University

Institute Type

Private

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Page

xvi, 63 .: ill. (col.) ; 30 cm. + CD

Subject

Medicine & Health

Language

English

Other

A thesis submitted in partial fulfillment of the requirements for the degree of Master of philosophy in pharmacology; Includes bibliographic references; Thesis (MS)--Riphah International University, 2019; English language; Call No: 610 ATA

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676711590091

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آرزوؔ لکھنوی

آرزوؔ لکھنوی
جناب آرزوؔ جلال لکھنوی کے جانشین اور اردو زبان و ادب کے ماہر و محقق تھے اس پر ان کی نگاہ بڑی وسیع تھی، انہوں نے اردو شاعری میں زبان کی سادگی و سہولت یا موجودہ اصطلاح میں ہندوستانیت کا نیا نمونہ قائم کیا، وہ حتی الامکان عربی اور فارسی کے مشکل الفاظ اور ترکیبوں سے پرہیز اور خالص ہندوستانی الفاظ استعمال کرتے تھے، جن شعراء نے ان کی تقلید کی کوشش کی وہ کامیاب نہ ہوسکے اور ان کی شاعری یا ہندی کوتاہ بن گئی یا بے رنگ و بے مزہ ہوگئی، آرزو کی یہ خصوصیت تھی کہ انہوں نے زبان کی ہندوستانیت کے ساتھ اردو شاعری کا آب ورنگ اور اس کی دلآویزی قائم رکھی، جو زبان پر ان کی غیر معمولی قدرت کا ثبوت ہے، انہوں نے اپنے کلام کے کئی مجموعے فغانِ آرزو، جہان آرزو، اور سریلی بانسری یادگار چھوڑے ہیں، ان دونوں اساتذہ کے بعد لکھنو پرانی یادگار سے خالی ہوگیا، بلکہ ان پر اس دورہی کا خاتمہ ہوگیا ، اﷲ تعالیٰ ان کی مغفرت فرمائے۔
(شاہ معین الدین ندوی، مئی ۱۹۵۱ء)

 

انسانی زندگی میں جنات کے اثرات

Among different creations of Allāh, Jinnāt have their own independent existence. By essence, they neither belong to the human race nor to the angelic world. One commonality between Jinnāt and human beings is that they both are provided with consciousness and can practice their own free-will in terms of choosing what is right and what is wrong, while angles are deprived of this ability. Jinnāt are mentioned in numerous places in the Qur’ān and the Aḥādīth of the Prophet SAW, so much so that it would be unreasonable to deny their existence. Henceforth, the scholars from every period of time have acknowledged their existence and it wouldn’t be wrong to claim that they all share almost similar views on them. Likewise, every Muslim group acknowledged their existence with the exception of Jahmīyah and Mu‘tazilah. As far as Jews and Christians are concerned, they too like Muslims believe in the existence of Jinnāt. To summarize, it is proven by means of multiplicity (Tawātur) of report from all the Prophets and Messengers and therefore, every follower of the heavenly religion has some sort of belief in the existence of Jinnāt. As far as their influence on the human beings is concerned, there are three major views prevailing among Muslims.  There are those who completely deny their existence and therefore, do not in anyway acknowledge their influence on human life. Then there are those who do believe in their existence but are of the opinion that they remain aloof from human beings and therefore, have no influence on the human life. The third opinion which is the opinion of the majority of the scholars is that not only Jinnāt exist but they have the power to influence and affect human beings as well. In this treatise, the opinion of the proponents of the third view is analyzed and their evidences from Qur’ān and Sunnah are discussed.

Organotin Iv Complexes of O, N, O and S, S Donor Ligands Derived from Dibasic Acids for Biological Applications

Herein we reports the synthesis of new mono and diorganotin(IV) complexes of Schiff baes/hydrazones with [O, N, O] and dithiocarbamates with [S, S] donor ligands. The methodologies described herein includes; the synthesis of five versatile Schiff bases/hydrazones ligands; N'', N''-4-bis(2-hydroxybenzylidene)oxalohydrazide(H4L1), N'', N''-4-bis(2-hydroxylbenzylidene)malonohydrazide (H4L2), N′, N′-4-bis(2- hydroxybenzylidene)succinohydrazide (H4L3), N′, N′-4-bis(2-hydroxybenzylidene)glutarohydrazide (H4L4) and N′, N′-4-bis(2-hydroxybenzylidene)adipohydrazide (H4L5). Herein the thesis also embodied another series of five dithiocarbamates ligands of the types; dipotassium-2, 2-oxalylbis(hydrazine-1-carbodithioat) (K2L1), dipotassium-2, 2-malonylbis(hydrazine-1-carbodithioate) (K2L2), dipotassium2, 2''-succinylbis(hydrazine-1-carbodithioate) (K2L3), dipotassium-2, 2''-glutaroylbis(hydrazine-1-carbodithioate) (K2L4) and dipotassium-2, 2''-adipoylbis(hydrazine-1carbodithioate) (K2L5). For the synthesis of organotin(IV) complexes the reaction between Schiff bases/ hydrazone ligands with [O, N,O] donor sites, mono- and diorganotin(IV)chlorides/oxides were carried out at various reaction conditions and obtained fifty new organotin Schiff bases/hydrazone complexes. The reaction between dithiocarbamae ligands with [S, S] binding sites, mono- and diorganotin(IV)chlorides were unsuccessful and end up with desulfurized isothiocynates. The structural and coordination chemistry of ligands with O, N, O and S, S binding mode/sites and thier organotin(IV) complexes were investigated by using FT-IR and single crystallographic studies in the solid sate. The solution chemistry of these complexes was investigated through mass spectrometry and some multinuclear (1H, 13C and 119Sn) spectal studies. The results revealed that Schiff bases/hydrazones coordinate to tin through a tridentate mode using [O, N, O] binding mode. The structural analysi of single crystal by X-ray technique showed that organotincomplexes procured from hydrazone with tridentate lignads (O, N, O), mono- and diorganotin(IV) chlorides exhibited distorted octahedral (oh) and distorted trigonal bipyramidal (tbp) geometry respectively.Based on the computational studies; the trigonal bipyramidal complexes showed a Sn···O tetrel bonding/interaction in the solid state. A computational study, in combination with the quantum theory of atoms in molecules (QTAIM) shows that the Sn···O interactions involved here are purely electrostatic in nature with little covalent character and leads to a shorter Sn···O [3.480(2 Å)] inter-atomic bond distance as compare to the reported “sum of van der Waals radii (3.92 Å)”. However, these types of interaction cannot be seen in the compounds when the phenyl /butyl groups or when the methylene spacer (-CH2-) between the two-hydrazone fragments is increased replaces the methyl groups. Finally, all the complexes were screened for anticancer activities using carbopaltin as a standard drug. The diorgantotin hydrazone complexes;wheremethyl and phenyl groups are attached to tin(IV)showed reasonable activities due tosolubility problems but the dibutyltin(IV) complexes of the hydrazone [O, N, O] ligands showed excellent activities and have been used as representative sample (compounds) against various cancer cell lines (HL-60, MCF-7 and HeLa ) obtained from human being. It is assumed that the high cytotoxic activities of the dibutyl tin(IV) complexes are due to its lipophilic character and can be compared with the activity of the standard drug (carboplatin). These results might be helpful in the rational drug designing of those complexes containing the dibutyl moiety.