جسٹس خواجہ محمد یوسف
سخت افسوس ہے کہ جسٹس خواجہ محمد یوسف ۹؍ دسمبر ۲۰۰۴ء کو میڈی ویو نرسنگ ہوم میں وفات پاگئے، اناﷲ وانا الیہ راجعون۔
وہ کلکتہ کے بہت محبوب اور ہر دل عزیز شخص تھے، مہینوں سے موت و زیست کی کشمکش میں گرفتار تھے، چند ماہ قبل برلاہارٹ ریسرچ سنٹر میں ان کے دل کا آپریشن ہوا تھا، اس کے بعد ہی سے کچھ نہ کچھ تکلیف رہتی تھی، انتقال سے پندرہ روز پہلے بیماری بڑھ گئی تو نرسنگ ہوم میں داخل ہوئے، ڈاکٹروں کی نگرانی میں امبولنس اور اسٹریچر پر تھوڑی دیر کے لیے ایران سوسائٹی میں تشریف لائے جہاں ۸؍ دسمبر کو ان کے بڑے صاحبزادے خواجہ جاوید یوسف کی شادی ہورہی تھی اور نکاح ہوتے ہی نرسنگ ہوم واپس چلے گئے، ۹؍ دسمبر کی صبح کو اچانک طبیعت زیادہ خراب ہوگئی مگر دوپہر تک سنبھل گئی تو کھانا تناول فرمایا اور سوگئے، شام کو پھر طبیعت خراب ہوئی اور ڈاکٹر کے آنے سے پہلے ہی مالک حقیقی سے جاملے۔
میت گھر پر آئی تو تعزیت کے لیے آنے والوں کا تانتا بندھ گیا، دوسرے دن غسل اور کفن کے بعد دیدار کے لیے جسد خاکی گھر سے متصل اسکول کے ہال میں رکھا گیا تو خلقت ٹوٹ پڑی اور جمعہ بعد جب جنازہ ایک نمبر گوبرا قبرستان لے جانے کے لیے اٹھا تو اس کے ساتھ مسلمانوں کے تمام طبقوں کے علاوہ سکھ، عیسائی، پارسی، ہندو اور بنگالی ہر مذہب و ملت کا ازد حام تھا جو زبانِ حال سے کہہ رہا تھا۔
چل ساتھ کہ حسرتِ دلِ محروم سے نکلے
عاشق کا جنازہ ہے ذرا دھوم سے نکلے
خواجہ صاحب کی موت ملک و ملت خصوصاً کلکتہ اور مغربی بنگال کے مسلمانوں کے لیے بڑا دردانگیز سانحہ ہے، ان کا وجود ان کے لیے رحمت و نعمت...
At the time of arrival of Muslim community in Sub-Continent Region and due to their settlement in the region Arabic Language has been prevailed and such as the system of its publication and learning has been commenced. Because the directives of Islam and laws are in the Arabic Language as per Quran & Sunna so that it is necessary to learn the Arabic language for the awareness of Islamic directions. So that to achieve the knowledge of Sharia inclu-ding the expertise the peoples of Sub-continent has been achieved the expertise of Arabic language, literature, knowl-edge Ilmul Saraf al-khawa, knowledge of al-ishtiaq & Ilmul Balaghta etc. Moreover it is clarify that Scholar of religious have shown their expertise so that the scholar of Arab have been convinced their expertise. The basic point of service in Arabic Language of Scholars of Sub-Continent that they do not served only to enhance the language but the cause of service was to serve themselves on religious matters and represents themselves on work hard and tried themselves to achieve the better performance of identification of Islam. A positive result and effects have been achieved as a sun shining of Islam is remaining and its waves are enhancing all around the world such as the sun shining of Islam is remained in Arab world such as the publication of literature is also remaining in the Sub-Continent region in the actual shape and saved. Because the Islam will remain till the day of judg-ment and its representatives/workers will born till the date such as the scholars of literatures will also born and they will save the knowledge of Arabic. They will alive till the Day of Judgment.
Thermal pressure alters the normal body homeostasis and cause rigorous injurious sound effects
on production of cattles. Dairy cattles are extra responsive to high temperature as they spawn
further energy expanded rate and this matter grasp particular consideration when the entire
picture of inclusive warm up is measured around the globe. Heat fright proteins are ever-present,
highly conserved proteins that cooperate a significant task in cell endurance through unusual
stresses. The present study was undertaken to assess peculiar relevance of HSP70 gene with heat
tolerance ability in Red Sindhi (Bos indicus), tropically evolved breed of Pakistan. The
aspiration of this study was to explore and portray the heat shock proteins gene diversity in
coding region of Red Sindhi cattle to understand their thermotolerance under hot conditions
using Polymerase Chain Reaction (PCR). The complete coding region of HSP70 is 1926bp long
without any intron, programming a protein of 641 amino acids located on chromosome No.23,
with predicted molecular weight (Mw) of 70,190.56 kDa. The functional parts of HSP70 protein
consist of an amino-terminal or N-terminal 44kDa ATPase domain (amino acid residues 1-386),
18kDa domain is peptide binding (a.a 384-543) and highly conserved 10kDa Carboxyl or
C-terminal domain (residues 542-640) in all eukaryotes. The phylogenetic examination of
mammalian HSP70 gene indicated that Red sindhi has showed (99.79 to 99.48%) homology
with Bos taurus, Bubalus bubalus and Capra hircus while least similar relationship was
observed with Canis lupus that was 86.34%. The results express that nucleotide as well as
deduced amino acid order was greatly preserved. Comparative sequence analysis of Red sindhi
HSP70 gene revealed a total of 14 single nucleotide polymorphic sites, of these 5 were
non-synonymous (C14T, G970T, C1469T, A1535T, G1560T) caused change in amino acid
sequence while 9 were synonymous. In non-synonymous SNPs the 1
one was reported and four
novel type. These 9 mutations caused no change in amino acid. 8 out of 14 were transition type
in which purines were replaced by just purines and pyrimidines replaced by other pyrimidines. 6
types were transversion mutations in which purines replaced by pyrimidines and vice versa. At
protein level, Red sindhi HSP70 gene has showed total 5 amino acid changes and two of five are
in N-terminal domain (M5T, A324S), remaining are in peptide binding domain (A490V,K512M,
Q520H). Probably damaging functional impact of amino acid change is seen in two of expressed
SNPs. These transformations can be worn as molecular genetics pointer to aid assortment for
anti-heat stress cattles. The findings of this study revealed that detected polymorphisms may be
associated with ability of bovine to adapt with tropical and harsh climatic conditions but
additional exploitation still required to draw the ending about molecular roots of thermotolerant
cattles.