کرم مجھ پر بھی اے فخرِ بشرؐ کر دے
خذف ہوں اک نظر کرکے گہر کر دے
سیہ راتیں لہو میں دوڑتی ہیں اب
من آنگن میں کبھی آکر سحر کر دے
میں جلوہ ہائے شہرِ علم پا لُوں گا
مگر پہلے عیاں اسرارِ در کر دے
ہو نقشِ پا ترا مسجودِ چشمِ تر
اِسی صورت بصارت معتبر کر دے
ثنا کی رُت قلم پر بھیج کر اب کے
مری شاخِ سُخن کو باثمر کر دے
The main emphasis of the study is on the academic performance and the stress management in applied science among the students of Mohtarma Benazir Bhutto Shaheed Sindh University Campus Dadu. What is the level of stress on the academic success of the students? How does it affect their lifestyle and health? This is what the research study covers to counteract the general stress among the students. The purpose of the study is to inquire and bring light to measure and check the present stress among students of the university. While doing the research a quantitative method was applied for collecting and analyzing the data. The Questionnaires were distributed among different students for this purpose. Innumerable factors of stress were found in the results and the factors were grouped in four categories which are; -Environmental Factors, Academic Factors, and Personal Factors. In environmental factors, the stress was about the happening the fate in the future. The students were found worried about future that what would happen about their fate? How it will happen? What is about to happen? When they came into contact with the new people it raised their stress. Also the class workload was the main reason for the stress among the students regarding academic factors. When the students were experiencing the workload of the class the group of the students came under stress. The last factor was a personal factor which was mainly due to the financial problem among the students. The stress of all categories can be managed through stress management courses and doing different extracurricular activities which will help to divert the attention of the students on different occasions. This study has drawn significant conclusions and Suggests further measures for practitioners which could help other to manage stress. The limitations are also mentioned so that those who are conducting research for the similar cases can extract better results and ways of curbing stress. A survey questionnaire was designed to collect the response from students, the five-point Likert scale was used from strongly agree to strongly disagree. SPSS-21 version was used to interpret the results through different quantitative techniques like descriptive, regression, and correlation. ____________
After stroke epilepsy is the second most common neurological disorder. It occurs due to abnormal neuronal discharge. It is characterized by unprovoked and recurrent seizures which are known as epileptic seizures. Clinically it is manifested in variety of ways from minor physical convulsions to severe tonic-clonic seizures with or without loss of consciousness. Status epilepticus is an acute exacerbation of common epilepsies and life threatening medical emergency, it must be treated or else it may cause serious damage to the brain and even death in many cases. For the management of epilepsy, the antiepileptic drugs, including second and third generations have extensively widened the choice of the drugs for the physicians; however, the efficacy and the antiseizure effects of these drugs are not satisfactory. There is limited choice of drugs for the management of status epilepticus. Keeping these challenges in mind the present study was carried out to investigate the synergistic anti-seizure/antiepileptic effects of combined regimens of Pregabalin with Amlodipine (PGB/AML) and Pregabalin with Nimodipine (PGB/NMD )on acute and kindled models of epilepsy in mice. Current research suggests that calcium influx in neurons plays important role in the genesis of seizures, therefore, the calcium antagonists have potential to be used as anticonvulsants. Anti-seizure actions of PGB can be augmented/potentiated or modified if given in combination with calcium channel inhibitors AML and NMD.The rationale for selecting this combination was based on facts thatAML and NMDhave synergisticanti seizure effects s on PGB and calcium channel blockers have inhibitory effects on voltage-gated calcium channel blockers. we designed the working hypothesis for the present study stating that the in combination-therapies AML and NMD would potentiate and enhance the anti-seizure effects of PGBby theirinhibitory and modulating effects on the calcium channels of the CNS.We examined and analyzed the combination therapy from multiple dimensions both in acute model of seizures as well as in kindled model of epileptogenesis.Our proposed hypothesis that anti-seizure actions of PGB can be augmented or modified if given in combination with AML and NMD had been substantiated by our results. The Combination regimens we employed in the instant experimental animal study were novel and demonstrated significant seizure protection. Our study has established that in both in-vivo models of seizures the combined regimens have demonstrated synergism between PGB and both calcium channel blockers (AML and NMD) incrasing the latent periods,reducing the duration of seizuresand increasing the mortality protection in mice.. We are inclined to hold that PGB:AML and PGB:NMD provided synergistic antiseizure effects in both seizure models. PGB:AMLin acute as well as inkindled modelsprovidedupto 100 percent seizure protection and complelety abolished the generation of seizures at the doses of 5055mg/kg of PGB with 12.5-15 mg/kg of AML(fifth and sixth doses)comparable to reference drugsVPT, PHTand DZ. PGB:NMDprovided 100 percent seizure protectionat the dose of 55mg/kg of PGB with 15 mg/kg (sixth dose) onlyin Kindled model of seizure. PGP:AML demonstratedmore efficacious and potent anti seizure effects as compared to PGB:NMD. We presume that both the calcium channel blockersexhibited their anti seizure effects by potentiating the antiseizure effects of PGB in both combined regimens.In the light of present study the major advantage of combination therpy would be that low doses of PGB could be employed that would be atleast six times in potency to itsindividual effects, thus reducing the doses of the PGB.The combination regimens broader spectrum of antiepileptic usage as compared to ther AEDs is another advantage.This study has provided some basic ground-work guidelines for the future clinical use of combination therapies of PGB with AML and NMD in various forms of epilepsies both for the short term management in conditions like status epilepticus and non epilepticus seizures as well as for the long term management of epilepsy. AML and NMDdeserves attention from a clinical point of view, as a potentially favorable drugs that could be applied in epileptic patients treated with PGB, who additionally requires calcium channel antagonist for reasons other than epilepsy such as hypertensive patients. Though, presently intravenous/ parenteral preparations of PGB is not available, however, it can be hoped that in near future the the availability of PGB parenteral formulations would provide alternate treatment options as combination therapies with calcium antagonist for the management of acute seizures