آپؐ کے نقشِ پا سے مزین زمیں، خاتم لمرسلیںؐ!
اَرضِ بطحا نے پائے ہیں کیسے نگیں، خاتم لمرسلیںؐ!
آپؐ کی بات کا صدق دل سے یقیں ،اے رسولِ امیں!ؐ
آپؐ کو غیر کہتے ہیں صادق امیں ،خاتم لمرسلیںؐ!
آپؐ کو جو رکھیںجان و دل کے قریں ،رحمتِ عالمیں!ؐ
صاف کہتا ہے قرآں انہیں مومنیں ، خاتم لمرسلیںؐ!
آپؐ کا جو ہوا ، سب اُسی کا ہوا ، اے حبیب خداؐ!
آپؐ کا جو نہیں ، وہ کہیں کا نہیں ، خاتم لمرسلیںؐ!
خوش طبع ، خوش ادا ، سیرت خوش صفا ، صورتِ والضحیٰ
خوش خط و خوبرو ، دلکش و دلنشیں ، خاتم لمرسلیںؐ
آپؐ کے بعد آئے نبیؐ دُوسرا ؛ میں نہیں مانتا
سیّد الاوّلیں ، سیّد الآخریں ، خاتم لمرسلیںؐ!
تُو لکھے حرفِ مدحت، پڑھے نعت کیا ، تیری اوقات کیا
دی گئے تجھ کو عرفانؔ! لحنِ حسیں ، خاتم لمرسلیںؐ
In the Islamic Law i. E. Quran and Sunnah the above mentioned topic has been discussed clearly and repeatedly to avoid any ambiguity in dealings in our daily life and agreements made between two parties or governments national or international levels. After intensive study I discussed and elaborated the said issue referring to the Qura’nic verses and sayings of the Prophet (SAW). The matter is of great importance; hence the Muslims Jurists have also given their valuable opinions in accordance with the Islamic Law which have been incorporated also to solve the issue. If we act upon these verdicts, we will be able to select the best among ourselves and form an ideal government and will discharge our duties honestly, and eventually our every act will show our responsibility to perform our duties and to give due share to the right person.
β-Amino acids-based peptides have gained much attention in synthetic community forthe last few decades. These acids are more flexible, conformationally more free due to the presence of additional carbon atom in chain and the ability to form more stable secondary structure, which make them a more promising candidate for drug designing in pharmaceutical industry, asymmetric synthesis and organocatalysis. The work presented in this thesis, concerned the synthesis of β-amino acid based- dipeptides, catalytic potential in direct aldol reaction and their biological evaluation. Two different chiral pool approaches were adopted for β3-amino acids’ synthesis; (i) Arndt-Eistert homologation, (ii) Direct homologation. The substitution of synthesized β3-amino acid at C-2 by -NH 2 substituent, (direct α- amination reaction of β3-amino acids). The β-amino acids coupling in solution phase for the preparation of different types of dipeptides resulted, proline-β3-amino ester dipeptides, proline-2, 3-diamino ester dipeptides, β-dipeptides and then screening in asymmetric aldol reactions in environmentally friendly solvents; water, brine and organic solvent (dry THF). The bioassay (Anti-fungal, anti-bacterial, and cytotoxicity) of protected β-amino-esters and protected-β-dipeptides was also performed.