مارنہیں پیار
زندگی میں انسان کو کئی حوالوں سے زندگی کا احساس دِلانا ہوتا ہے اور ثابت کرتا ہے کہ وہ شاہراہ حیات پر رواں دواں ہے خواہ وہ راستے خار دار جھاڑیوں سے پر ہو یا اس پر از ہارواثمار سے لدے درخت کی ٹہنیاں سر جھکائے محوِ حمدوثناء ہوں۔ زندگی مسائل سے بھری ہوئی ہو یا اس کی رنگینیاں ، رعنائیاں اظہر من الشمس ہوں۔ انسان کو کسی نہ کسی صورت میں ان سے واسطہ رہتا ہے۔ انسان کبھی خوش وخرم ہوتا ہے اورکبھی ناراضگی کے باعث اس کی پیشانی پرشکن واضح ہوتی ہے۔
زندگی میں انسان سے کوئی اچھاعمل سرزد ہوتا ہے تو اسے انعام و کرام سے نوازا جا تا ہے اور اگر اس سے کوئی خطا سرزد ہوتی ہے تو اس کو اس کی سزا بھگتنا پڑتی ہے، اچھے کام کی انجام دہی پراچھے صلے کا سزاوار ٹھہرتا ہے اور سہواً یا عمداً کوئی غلطی ہو جائے تو وہ سزا کا مستحق ٹھہرتاہے۔ دین اسلام میں بھی جزاء وسزاء کا تصور موجود ہے، عابد اور صالح مسلمان کے لیے وعدہ ٔحورو قصورموجود ہے۔ خاطی اور گنہگار کے لیے وعید جہنم کا تصور موجود ہے۔ اگر یہ تصور ختم ہو جائے تو حصول راحت کے لیے کی جانے والی مساعی جمیلہ کی چمک ماند پڑ جائے گی اور سزا کی طرف مائل ہونے والی حرکتیں اور اعمال سیٔہ کی کثرت ہو جائے گی’ ’مار‘‘ کا تصور موجود ہے اور ’’ پیار ‘‘ کا تصور بدرجہ اتم موجود ہے۔
یہ ہماری عظمت ہوگی ’’مارنہیں پیار‘‘ کو اپنے معاملات میں جب داخل کریں گے، اور محبت و شفقت کا وتیرہ اپنائیں گے تو اس خصلت حمیدہ کی آفاقیت سے کسی طور بھی صرف نظر نہیں کر سکتے۔ یہ اسلوب ایک طالب علم کے لیے فرحت بخش ثابت ہوگا۔ اگر چہ مار کے تصور سے تاریخ...
Oral squamous cell carcinoma (OSCC)being the world’s most prevailing and frightening cancerous disorder lacks the sufficient data in Pakistan despite of its higher magnitude and prevalence. Objective: This study was specifically designed and conducted with the aim to identify the frequency of this disorder along with causative factors in past three years in a tertiary care hospital of Lahore, Pakistan. Methods: Epidemiological study was conducted using retrospective randomized method and all pre-requisites were filled. The clinical profiles of patients were collected from Maxillofacial and Oral Surgery Departmentof Pathology, Mayo Hospital Lahore. Patients who had undergone treatment for OSCC were contacted and interviewed for information about demographic regions, previous history of malignancy, disease onset, chewing habits, exposure to pesticides, industrial exposure to metals etc. And all particulars were not and compiled on questionnaire. Results: A total of 54 patients from different districts of Punjab participated in the study. Percentages for each possible causative chewing habit were calculated and 87.50 % of population was found addicted to different habits. Genetic factor might have contributed in remaining for development of OSCC. Conclusions: Informative data provided in this study will be helpful to be used by the government and private health agencies while designing and planning management of oral health problems and allocating health budgets in focusing this issue
Fusarium oxysporum f.sp. lycopersici (Fol) cause Fusarium wilt, a devastating disease in tomato, affecting the crop yield and causes economic loss worldwide. Synthetic fungicides are widely used in controlling the wilt disease, however they have been questioned due to their environmental concern. Therefore, this study was designed to screen fungal species for their antifungal potential against this destructive disease. Initial dual culture assay of fungal species revealed Aspergillus niger, Penicillium EU0013 and Alternaria solani as inhibitory to the pathogen due to their higher inhibition (%) 51.54 ± 1.09, 63.85 ± 3.26 and 46.15 ± 2.18 % respectively. During culture condition optimization studies, Glucose peptone yeast extract broth (GPYB) was found suitable for higher antifungal activity and production of compounds from A. niger and Penicillium whereas A. solani showed higher antifungal activity in glucose nutrient broth (GNB). The three fungal species showed maximum zone of inhibition against the pathogen at 30 °C and at slightly acidic pH. Penicillium sp. showed maximum zone of inhibition (9.20 ± 0.14 mm) amongst the three fungal species against Fol, therefore this species was selected for in vivo pot experiments. It was observed that with the application of Penicillium extract, plants showed no symptoms of wilting even after 40th day of plantation. Bioassay guided investigation of the fungal species leaded to isolation of eight antifungal compounds. Among these compounds, two completely new from Penicillium sp. with m/z 255 and 223 [M+H]+ and one from A. solani with m/z 273 [M+H]+ were characterized. Three known compounds from A. niger with m/z 557, 571 and 665 [M+H]+ and two from Penicillium sp. with m/z 143 and 239 [M+H]+ and one from A. solani with m/z 273 [M+H]+ are reported for their antifungal activity against Fol the first time in this study. MIC value of the purified compounds showed that the compounds were active between 40 to 120 μg·mL-1. Identification and characterization of these antifungal compounds might provide lead structures for developing them as fungicide in future.