Association of consanguineous marriages with congenital anomalies Cousin marriages and birth defects

Congenital anomalies are a major health problem all over the world; especially it is important cause of deaths and birth defects, chronic illness and disability in infants. The major cause of this is consanguineous marriages. Generation of cousin marriages have significant association with congenital anomalies Objective: To find out the association of consanguineous marriages with congenital anomaliespresent at the time of birthMethods: A cross sectional study was conducted at District Head Quarter Hospital, Okarafrom May to August, 2018. 100 adult individuals aged between 19 to 55 years, with and without cousin marriage of both genders were consecutively enrolled. Participants were assessed through pre-tested questionnaire, with prior written informed consent. Unwilling married individuals and individuals from other hospitals were not selected Results: According to resultsthere was a significant association between generation of cousin marriages with congenital anomalies present at the time of birth, as p value was 0.002Conclusions: Study concluded that the generation of cousin marriages has significant association with congenital anomalies present at the time of birth and due to cousin marriage 59% of the couples had congenital abnormalities in their children and 85% had genetic disorders.

A Study on the Synthesis and Biological Evaluation of Some 3, 6-Disubstituted-1, 2, 4-Triazolo[3, 4-B]-1, 3, 4-Thiadiazoles and 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents used as a cure against a number of human ailments. The present work deals with the synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazoles and 2,5-disubstituted-1,3,4-oxadiazoles bearing adamantyl and aryl moieties. The synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was carried out starting from aryl carboxylic acids. On the other hand, 2,5-disubstituted-1,3,4-oxadiazoles were synthesized using two distinct routes starting from either aryl carboxylic acids or aryl nitriles. The structures of the synthesized compounds were confirmed by IR, 1 H- and 13 C-NMR, EIMS and XRD analysis. The target compounds were screened for their antitumor, antiviral, antibacterial and antifungal potential. Among the tested compounds, 3-(2-methylphenyl)-6-adamantyl- 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (4a) and 3-(2-fluorophenyl)-6-adamantyl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazole (4d) exhibited prominent antiproliferative activity against human CD4 + T-cells containing an integrated HTLV-1 genome (MT-4) with CC 50 of 45 μM and 47 μM, respectively. These compounds were also found to be active against human acute T-lymphoblastic leukemia (CCRF-CEM) cell lines with CC 50 of 40 μM each. 3-(3-Methylphenyl)-6-adamantylmethyl-1,2,4-triazolo[3,4-b]- 1,3,4-thiadiazole (4n) showed moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.90 μg/mL, but no selectivity could be witnessed. Similarly, 3-(3-methylphenyl)- 6-adamantylmethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (5n) was found to be potent exhibiting moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.86 μg/mL. Furthermore, oxadiazole (9a) and 2-adamantyl-5-(2-(2-methylphenyl)-1,3-thiazol-4-yl)-1,3,4- 2-adamantyl-5-(2-(2-bromophenyl)-1,3-thiazol-4-yl)-1,3,4- oxadiazole (9j) showed significant inhibition of HIV-1 and HIV-2 with EC 50 of >10.50 μg/mL and >10.90 μg/mL, respectively. However, antibacterial and antifungal activities of all the compounds were found to be non-significant at non-toxic concentrations.