A Protective Effect of Commercial Green Tea on Ibuprofen Induced Changes in Renal Function Tests of Adult Rats

Background: Nephrotoxicity of ibuprofen is a growing international public health problem in the wake of excessive use of the drug for the treatment of a broad spectrum of diseases in both adults and pediatric patients. Objectives: To present an overview of the protective effect of the green tea on ibuprofen-induced changes in the biochemical markers of the adult rat kidneys. Methods: It is an experimental study conducted in the department of Anatomy, Army Medical College Rawalpindi. The investigation was led on 30 male and non-pregnant female Sprague Dawley rodents of 9-11 weeks old enough and going in weight from 200-330 gm. The animals were divided into three groups consisting of 10 animals each; group A served as control, each animal in group B was given ibuprofen at a dose of 120 mg/kg/day and each animal in group C was given both green tea at a dose of 1ml/100g/day and Ibuprofen 120mg/kg body weight for a period of 9 weeks. Ibuprofen manufactured by Abbot Laboratories (Pvt.) Limited was utilized. Green tea was obtained from local market. Data was collected at the end of experimental period and was analyzed using SPSS version 22. One Way ANOVA was exerted, afterwards by post-hoc Tukey test to find out intergroup differences for quantitative variables. The results were depicted as mean ± standard deviation (mean ± SD). A p value < 0.05 was believed significant. Results: Green tea administration had a significantly favorable effect on serum urea (mg/dl) (Group A=21.9 ± 2.8, Group B=93.2 ± 3.9, Group C=36.4± 3.0; p<0.001) and serum creatinine (mg/dl) (Group A=0.9 ± 0.22, Group B=2.4± 0.52, Group C=0.97 ± 0.3; p<0.001). Conclusions: Green tea had ameliorative effects on the ibuprofen-induced changes in the biochemical markers of the adult rat kidneys.

Synthesis of Metal Halide Perovskite Materials for Light Harvesting Applications

The work described here deals with the synthesis and characterization of inorganic and hybrid perovskite for light harvesting applications. The inorganic lead and copper based metal halide perovskites were prepared and their fluorescent sensing ability was explored. The all-inorganic bulk CsCuCl3 and CsCuBr3 perovskites were synthesized by wet chemical method and were used for sensing of lead ions and aqueous contamination in DMF respectively. On the other hand, aerosol assisted chemical vapour deposition (AACVD) technique was adopted to fabricate thin films of CsPbBr2I. The oleylamine capping agent facilitates the formation of morphological controlled microsquares on the glass substrate. In addition, nanosquares of CsPbBr2I perovskite were prepared by wet chemical approach. Furthermore, phase pure micro sized crystals of CsPbBr2I were obtained by using TOP as antisolvent as well as capping agent to control morphology of microcrystals. These microcrystals were then used for nitrophenol detection. The CsPbBr2I bulk perovskite were used to fabricate ZnO based planner solar cell which have shown promising power conversion efficiency of 4.8%. The as-prepared metal halide perovskite were characterized by powdered X-ray diffraction spectroscopy (pXRD), UV-Visible spectroscopy (UV-Vis), photoluminescence spectroscopy (PL), thermogravimetric analysis (TGA), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). In addition, thermal and water stable OHNH3PbX3 hybrid perovskites were prepared for photocatalysis application to degrade dye molecules. Whereas, the synthesis of (Cs)x(PhNH3)2-xPbBr4-xIx perovskite nanoparticles were performed to develop qusai-2D structures. The replacement of B site cations to develop lead free CH3NH3Pb1-xCuxBr3 hybrid perovskites was described. The gradual replacement of lead with copper leads to the formation of lead free hybrid perovskite nanoparticles and thin film. These hybrid perovskites have shown interesting optical properties.