علّامہ ابن الجوزی کی تفسیر (زاد المسیر فی علم التفسیر) میں اشعار سے استشہاد کا علمی اور تحقیقی جائزہ

This paper describes that if we want to know about poetry we must understand that out of context we can never arrive at our destination. The Qur‘ān should be read and understood in totality of its message and spirit. Its verses are local and universal. Some verses are in local environments but leave universal and external message. The verses of Sūrah Yāsīn and Sūrah Najm related to poetry clearly exhibit the truth that God rejected the claim of the infidels who regarded the Qur‘ān as the book of poetry and Prophet Muhammad as a poet. It is an apt reply to the infidels that Qur‘ān is a message of God with a serious mission and motto. The Holy prophet used to ask people to recite the Holy poetry of Abu ║ālib. ╓assān bin thābit used to recite ‘Nāt’ in the presence of the Prophet. They enhanced the divine mission of the prophets through their facile pen and noble spirit. Hence in the light of above brief dissertation we can profess that Islam does not oppose poetry if it is written on didactic and divine lines.

Formulation and Characterization of Cardioprotective Nanosuspensions from Indigenous Medicinal Plants

Present research work was planned for the formulation of cardioprotective nanosuspensions of four indigenous medicinal plants with improved bioavailability and better therapeutic efficacy. Ongoing research was divided into four different phases. First phase of the study was comprised of formulation and optimization of formulative parameters for the preparation of stable nanosuspensions by using CCD design of RSM. Characterization (ZP, SEM, AFM and FTIR) and stability studies of optimized nanosuspensions was the second phase of the study. In third phase of study, in-vitro dissolution testing and in-vivo pharmacokinetic profile of selected nanoformulations was determined. In fourth phase, different in-vitro and in-vivo bioactivities and toxicity studies of optimized nanosuspensions were evaluated with reference to the respective coarse plant suspensions. Results of stabilizer screening demonstrated that SLS was the best stabilizer for the formulation of A. cepa and C. oxyacantha nanosuspensions. HPMC was the selected stabilizer for P. nigrum and P-80 was chosen for the formulation of T. arjuna nanosuspensions. Among the optimized nanosuspensions, minimum particle size with appropriate PDI value was possessed by T. arjuna (79.1nm, 0.244) followed by C. oxyacantha (121.3nm, 0.241), P. nigrum (172.9nm, 0.328) and A. cepa (275.5nm, 0.415) nanosuspension. Results of zeta potential studies confirmed the stability of the optimized nanosuspensions. Results of AFM and SEM illustrated that nanosuspensions were in nanometer range with varied particle size and morphology. FT-IR studies indicated slight interaction between herbal extracts and stabilizers. Moreover, optimized nanosuspensions of all the four medicinal plants showed better stability at refrigerated conditions. Dissolution and pharmacokinetic studies demonstrated improved results for nanosuspensions as compared to coarse suspensions of the respective plant extracts. In-vitro (antioxidant, antimicrobial, hemolytic, thrombolytic) and in-vivo (cardioprotective) bioactivities also revealed better therapeutic efficacy of nanosuspensions over coarse suspensions. Results of toxicity studies confirmed the non-toxic nature of formulated nanosuspensions. From the present results it was concluded that nanosuspensions of the selected herbal extracts can be used as a better alternative to treat cardiovascular diseases with improved therapeutic efficacy as compared to their conventional coarse suspensions.