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Real Time Target Tracking and Error Minimization Using Kalman Filter

Thesis Info

Author

Mateen Ahmad.

Department

Department of Computer Science &Amp; Engineering; UET

Institute

University of Engineering and Technology

Institute Type

Public

Campus Location

UET Main Campus

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2004

Thesis Completion Status

Completed

Page

xi, 70 .: ill.;diagrs.; tabs ;

Subject

Computering

Language

English

Other

Call No: 017.8 M 41 R

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676712741317

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چھتری زمیندار

چھتری زمیندار

            وسط اپریل گذشتہ میں بمقام بردوان ایک چھتری زمیندار نے ۶ بجے شام کو وفات پائی، متوفی کا تعلق چونکہ سورج بنسی خاندان سے تھا، اس لئے نعش شب میں نہیں جلائی جاسکتی تھی، دوسرے روز صبح سویرے متوفی کے ایک عزیز نے نعش کا فوٹو لیا، لیکن جب فوٹو تیار ہوا تو اس میں پانچ شکلیں اور بھی نظر آئیں، جن میں سے ایک شکل مرحوم کی زوجہ متوفیہ اور ایک مرحوم کے بچہ کی پہچانی گئی، جس کا مدت ہوئے انتقال ہوچکا ہے، باقی تین شکلیں بہت دھندلی آئی ہیں، ان کی شناخت نہ ہوسکی، بنگال کے اخبارات اس روایت کے ذمہ دار ہیں، اور بنگال کے سائنٹفک حلقوں میں اس خبر نے ایک خاص تحریک پیدا کردی ہے۔ (مئی ۱۹۲۰ء)

عورت کی ازدواجی حیثیت اور تولیدی صحت سے متعلق تصورات کا تجزیہ

The research examines socio-cultural stereo-typed beliefs and customs of Pakistani society regarding women’s conjugal rights and reproductive health. Islamic teachings recognize and ensure both categories of women rights; general and specific. Islam has acknowledged man and woman as equal and equivalent partners of the family system. There mutual cooperation lays the foundation of a peaceful, prosperous and healthy society. According to Islamic injunctions, the socio-economic environment of the society must ensure mutual trust, matrimonial harmony, and respect of rights for both men and women. The social norms need consistent evolution to be conducive to a happy life of individuals. It goes without saying that population growth must go hand in hand with papulation planning while prosperity is directly proportional to proper management of both human and economic resources. The present article analyzes the social stereo-types about women, their conjugal rights, family planning and care for women’s reproductive health, in the light of guidance provided by Qur’an and Sunnah. Islam.

Genetic Mapping and Mutation Analysis of Genes Causing Human Hereditary Skeletal Disorders

Genetic defects in the complex processes of embryonic development of the skeleton and its postnatal maintenance result in different types of clinically diverse and genetically heterogeneous skeletal disorders. This presents a diagnostic challenge because of their nonspecific presentation, variable clinical features, highly overlapping phenotypes and lack of recognition as a discrete clinical entity. The research work, presented in this dissertation, describes clinical and molecular investigations of fourteen families (A-N) segregating various forms of skeletal disorders in autosomal recessive pattern. Clinical examinations were performed at local Government hospitals. Blood samples were collected from both affected and unaffected members of the families. Genomic DNA, extracted from the blood samples, was used for microsatellite and SNP based genetic mapping and whole exome and chain termination sequencing. Clinical features, observed in affected members of six families (A-F), were analogous to a condition named as mucopolysaccharidosis. Linkage in these families was established to chromosome 16q24.3 harboring GALNS gene. Sanger sequencing revealed two novels (p.Phe216Ser, p.Glu121Argfs*37) and two previously reported mutations (p.Pro420Arg, p.Arg386Cys) in GALNS gene in the six families. In silico analysis predicted that the missense mutations affect structure and function of the GALNS protein. Clinical and radiographic examinations of affected members in three families (G-I) underscored the manifestations of acromesomelic dysplasia. Microsatellite based genotyping followed by sequence analysis of the NPR2 gene identified three novel missense mutations (p.Arg749Trp, p.Arg601Ser, p.Leu314Arg) in the families. Human genome scan using SNP microarray followed by exome sequencing discovered a potentially casual frameshift mutation (c.594-595insT; p.Gln198Thrfs*21) in a novel gene KIAA0825 in the family J segregating post-axial polydactyly in an autosomal recessive manner. Affected individuals in family K exhibited peculiar clinical features including post axial polydactyly, speech impairment, hearing impairment of variable degree and proportionate short stature. This condition represented mild form of Joubert Abstract Genetic Mapping and Mutation Analysis of Genes Causing Human Hereditary Skeletal Disorders XVIII syndrome. Whole exome sequencing in the family revealed a novel in-frame deletion mutation (c.1115-1117delCCT; p.Ser372del) in the MKS1 gene. In silico analysis revealed that Ser372 residue resides in the “B9” interacting region of the MKS1 protein and inframe mutation (p.Ser372del) causes alteration in the conformation of mutant protein with two extra α helixes. The present study described three families (L-N) with split hand/foot malformations. In two families (L, M), genetic mapping followed by Sanger sequencing detected a novel frameshift mutation (c.300-306dupAGGGCGG; p.Leu103Argfs*52) in the WNT10B gene. In the third family (N), whole exome sequencing accompanied by SNP microarray, identified six nucleotides duplication (c.217-222dupCACCCG; p.His73_Pro74dup) in a novel causative gene HOXD8. The work presented in the dissertation resulted in the following publications. 1. Irfanullah, Saadullah Khan, Imran Ullah, C. Arnoud Meijer, Marlies Laurense Bik, Johan T den Dunnen, Claudia AL Ruivenkamp, Marriët JTV Hoffer, Gijs WE Santen, Wasim Ahmad (2016). Hypomorphic MKS1 mutation in a Pakistani family with mild Joubert syndrome and atypical features: expanding the phenotypic spectrum of MKS1-related ciliopathies. American Journal of Medical Genetics Part A 9999A:1–5 2. Irfanullah, Muhammad Umair, Saadullah Khan, Wasim Ahmad (2015). Homozygous Sequence Variants in the NPR2 Gene Underlying Acromesomelic Dysplasia Maroteaux Type (AMDM) in Consanguineous Families. Annals of Human Genetics 79: 238–244 3. Abdul Aziz, Irfanullah, Saadullah khan, Faridullah khan zimri, Noor Muhammad, Sajid Rashid, Wasim Ahmad (2014). Novel homozygous mutations in the WNT10B gene underlying autosomal recessive split hand/foot malformation in three consanguineous families. Gene 534: 265–271. 4. Irfanullah, Abdul Nasir, Sarmad Mahmood, Sohail Ahmed, Muhammad Ikram Ullah, Asmat Ullah, Abdul Aziz, Syed Irfan Raza, Khadim Shah, Saadullah Khan, Muhammad Jawad Hassan, Wasim Ahmad (2016). Identification and in silico analysis of GALNS mutations causing Morquio A syndrome in eight consanguineous families. Turkish Journal of Biology: DOI:10.3906/biy-1607-81 Abstract Genetic Mapping and Mutation Analysis of Genes Causing Human Hereditary Skeletal Disorders XIX 5. Asmat Ullah, Ajab Gul, Muhammad Umair, Irfanullah, Abdul Wali, Farooq Ahmad, Abdul Aziz, Wasim Ahmad (2017). Homozygous sequence variants in the WNT10B gene underlie split hand/foot malformation. Genetics and Molecular Biology (Submitted) 6. Irfanullah, Muhammad Ansar, Saadullah Khan, Abdul Aziz, Wasim Ahmad. Exome sequencing revealed a novel gene KIAA0825 underlying autosomal recessive postaxial polydactyly (In Preparation). 7. Irfanullah, Saadullah Khan, Maaike Verschuren, Marlies Laurense Bik, Johan T den Dunnen, Claudia AL Ruivenkamp, Marriët JTV Hoffer, Gijs WE Santen, Wasim Ahmad. Human HOXD8 is a novel candidate gene causing autosomal recessive split hand foot malformation in a large Pakistani consanguineous family (In Preparation) 8. Irfanullah, Syed Zohaib Tayyed Gilani, Saadullah Khan, Wasim Ahmad. Homozygous mutations in NPR2 gene underlying Acromesomelic dysplasia in Pakistani families (In preparation)