حفیظ الرحمان احسنؔ(۱۹۳۴ء۔پ) کا اصل نام حفیظ الرحمان اور احسن ؔتخلص کرتے ہیں۔ آپ پسرور کے ایک مذہبی گھرانے میں پیدا ہوئے۔ ۱۹۵۹ء میں اسلامیہ کالج سول لائن لاہور سے ایم۔اے عربی کیا اور گورنمنٹ انٹر میڈیٹ کالج فیصل آبادمیں عربی لیکچرا ر کی حیثیت سے تعینات ہوئے۔ ۱۹۶۳ء میں مرے کالج سیالکوٹ میں عربی کے لیکچرا ر کے طورپر تقرری ہوئی۔ ۱۹۶۶ء میں لاہور میں ایوانِ ادب ادارہ قائم کیا۔ (۸۶۴) حفیظ الرحمن احسنؔ کا پہلا شعری مجموعہ ’’ننھی منھی خوبصورت نظمیں‘‘ ایوانِ ادب لاہور سے ۱۹۸۳ء کو شائع ہوا۔ دوسرا شعری مجموعہ ’’فصلِ زیاں‘‘ سدا بہار پبلشرز لاہور نے ۱۹۹۰ء میں طبع کیا۔ ’’
Congenital Heart Defect (CHD) is a multifactorial disorder based on both genetic and environmental factors involved in development. The basic problem lies in the structure of heart leading to CHD that occurs in walls, valves, arteries and veins of heart. During cell cycle, the gene that controls this process may mutate, causing disturbance in any portion of heart leading to disturbed blood flow, blood flow in wrong direction or complete blockage. Defect may range from simple with no manifestations to complex with severe symptoms. Simple defects need no treatment while some babies with complex birth defects during birth require special care, vaccination, medication or otherwise treated with surgery. The incidence of CHD has declined from 80 to 20% due to progress in heart surgery techniques, medical treatment and interventional cardiology. Various genetic and non-genetic increase the susceptibility for CHD. The diagnosis and treatment of CHD has greatly improved in recent years. Almost all the children with CHD survive to adulthood and spend healthy and active lives after being treated.
This dissertation is divided into seven chapters. The first chapter is general overview which introduces transition metals catalyzed cross coupling reactions especially Palladium catalyzed cross-coupling reactions. These have recently emerged as one of the most powerful and fundamental transformations in organic syntheses. Among the several palladium catalyzed cross-coupling reactions, Suzuki-Miyura cross-coupling reaction has become an extremely important method for the construction of carbon-carbon bonds. The second chapter describes the synthesis of fluorinated terphenyls synthesized via Suzuki cross coupling reaction of 1, 4-dibromo-2, 5-difluorobenzene with different boronic acids. Fluorinated terphenyls were obtained in high yields. Structures of these compounds were confirmed by 1H-NMR, 13C-NMR, GC-MS, FT-IR and single crystal X-Ray analysis. Mono-arylation was also observed in a compound 4, 4’-dibromo-2, 5-difluorobiphenylby using 1 equivalent of arylboronic acid. The third chapter describes the syntheses of 3-arylated quinolines synthesized via Suzuki cross coupling reaction of 3-bromoquinoline with different boronic acids. Several trials were made to enhance yield of final products by using different catalytic systems. Extensively diversified arylated quinolines were synthesized in relatively high yields. Structures of these compounds were confirmed by 1H-NMR, 13C-NMR, GC-MS, FT-IR and single crystal X-Ray analysis. Synthesized arylated quinolines are not readily available by any other methodologies. The Fourth chapter describes the syntheses of 2, 5-diarylated pyridine synthesized via Suzuki cross coupling reaction of 2,5-dibromopyridine with different boronic acids. Diversified results were obtained as 4 different products 5, 6, 8 and 9 were obtained even after using 2.2 equivalents of different aryl boronic acids. Regioselectivity is also studied and well characterized with help of XRD analysis. Abstract x The fifth chapter describes the experimental procedures and characterization data of synthesized compounds. The sixth chapter describes the biological activities of the synthesized compounds. These compounds were subjected to various biological activities like anti-bacterial, anti-fungal, antinociceptive and urease inhibition activities. The overall biological activity screening demonstrated that majority of these compounds are significantly bioactive. The last chapter describes the solubilization of quinoline derivatives in micellar solutions of surfactants. In micellar solutions of surfactants the solubility of the quinoline derivatives increased linearly with the increase in surfactant concentration irrespective of the type of surfactant. The molar solubilization ratio (MSR), micelle-water partition coefficient (KM), and the Gibbs energy of solubilization (Δ???) of these compounds in the micelles were determined and correlated with each other. This comparative study can be used to select an appropriate medium for the quinoline derivatives solubilization.