''المواھب اللدنیۃ با لمنح المحمدیۃﷺ'' کا تعارفی و تجزیاتی مطالعہ An Analytical study of the

Although Imam Qusṭalānī, in compiling his book "Al-Mawāhib Al-Laduniyat Bil Minḥ Al-Muhammadiyah", has followed the footsteps of Qazi Ayaz’s book Al- Shifā. But many chapters and information are unique to them and he has expanded this book with his additions and made it a treasure trove of information. This book is a beautiful fusion of the traditions of Muhaddithin and Ahl-e-Siyyar. Because he was not only a muhaddith but also a biographer. Were his greatest service in the learning of Hadith is "Irshad Al-Sārī Sharh Saḥiḥ Bukhārī", there his most significant service in Sira is this book. He has used the traditions of both the narrators and the Biographers in compiling it. In this book, the locks of meanings are opened with the keys of Fatḥ Al-Bārī Li Ibn-e-Hajar ‘Asqalānī. In other words, he has benefited a lot from Fatḥ Al-Bārī Sharḥ Bukhari and has gained a lot of confidence. A large number of scholars have used this book, including Shiblī Nu‘mānī, who has made extensive use of it in his Sirat un-Nabiﷺ . Due to its popularity, many of its rates have been written. The most detailed of these is the Zurqānī rate of Qusṭalānī. The great scholar like Imam Zarqani has commented in eleven volumes of this book, which is proof of its authenticity, noteworthy, and worth reading and treasure. Sheikh Nūruddin Ṭrabulsī gave Sharh and great people like Safiuddin Qasashi, Burhanuddin Ibrahim Maimoni, Shamsuddin Muhammad Shobri Misri and Nooruddin Ali Qari embellished this book with their footnotes. On the one hand, it teaches love and respect for the Holy Prophet ﷺ and on the other hand, it mentions the rights of the Holy Prophet ﷺ and the rewards for their payment. The writing style of the book is simple and smooth as well as eloquent and eloquent. The temptation is not so long that the length will be too long for the reader, nor is it so short that access to the concepts and demands will not be possible due to the brevity. The book has been read by the people and it has been adopted by biographers as an authentic and reliable source. Because of its importance and usefulness, an introductory and analytical study of this book will be presented in this article.

Biochemical Profiling and Synergistic Potential of Medicinal Plants As Hepatoprotective

The objective of this study was to find out any alternative natural product to address the hepatic problems. Though many medicinal plants have been reported for hepatoprotective potential but still there is a need to explore further their medicinal effect on scientific basis. Hepatoprotective potential of selected medicinal plants (Silybum marianum, Artemisia absinthium and Rheum emodi) in different combinations against paracetamol induced liver damage was studied. The phytochemical constituents of selected medicinal plants in combinations were tested by measuring total phenolic content (276.26 to 356.57 GAE) and total flavonoid content (13.01 to 25.63 CE). The antioxidant activity of selected medicinal plants in combination was evaluated through DPPH (76.81 to 92.33 % inhibition) and reducing power in term of absorbance (0.964 to 1.652). The antioxidant effect of medicinal plants at cellular level was further explored using H2O2 induced DNA damage on pUC19 plasmid DNA. It was found that the protective effect of plants extracts was concentration dependent. The safety of medicinal plants was evaluated through various toxicological assays including hemolytic, brine shrimp lethality and mutagenicity. The cytotoxicity findings showed that the plants are safe and may be used as medicine. Biochemical profiling of selected medicinal plants was performed through liquid chromatography mass spectrometry (LCMS). The hepatotoxin, paracetamol significantly increased the levels of SGPT, SGOT and ALP whereas the levels of protein and albumin were decreased. The combination containing silymarin extracted from S. marianum, aqueous mixture of both A. absinthium and R. emodi were given to experimental animals with different doses. The hepatoprotective effect was evaluated by studying various biochemical parameters (SGPT, SGOT, ALP, Protein and Albumin). The administration of medicinal plants in various combinations altered the biochemical markers and exhibited significant hepatoprotective activity. The experimental animals were slaughtered at the end of study. The levels of antioxidant enzymes, superoxide dismutase, glutathione peroxidase and catalase were decreased in positive control group (paracetamol treated). The levels of antioxidants enzymes in medicinal plants treated groups remained in normal limit as in the control group. Histopathological examination of liver tissues of control and treated animals showed significant difference indicating that the combinations of selected medicinal plants successfully restored the liver functions. Although majority of the combinations restored the liver functions but the most suitable combination was the least quantity i.e. 100 mg of each plant. It is concluded that the medicinal plants in combination used in this study is an effective and promising formulation against paracetamol induced liver damage.