خواجہ عبدالمجید
افسوس ہے پچھلے دنوں ملک کے مشہور نیشنلسٹ خواجہ عبدالمجید صاحب بیرسٹر ایٹ لا کا انتقال ہوگیا۔مرحوم صفِ اوّل کے نیشنلسٹ مسلمان اور قومی کارکن تھے۔ علی گڑھ کے تعلیم یافتہ اوراُس کی تہذیبی روایات کے پورے حامل ہی نہیں بلکہ ترجمان تھے۔برسوں سے مسلم یونیورسٹی کورٹ اوراُس کی اکزیکٹیو کونسل کے بہت بااثر ممبر تھے اوریونیورسٹی کے معاملات میں بڑے جوش وخروش اور سرگرمی سے حصّہ لیتے تھے۔بہت پرانے کانگریسی کارکن تھے اوراس لیے کانگریس کے عمائد اورپنڈت جواہرلال نہرو اورسابق صدر جمہوریہ دونوں خواجہ صاحب کابڑاادب اورلحاظ کرتے تھے مگر حق بات کہنے اورکرنے میں اُنہیں کبھی تامل نہیں ہوتاتھا۔بڑے مخلص،انتہائی وضعدار،شرافت ومروت اوراخلاق ومکارم کا نمونہ تھے، اُن کا دروازہ ہرضرورت مند کے لیے ہروقت کھلارہتا تھا۔ اب ادھربرسوں سے معذور تھے، مگرقومی کاموں میں اس کے باوجود تندہی سے منہمک رہتے تھے۔اب ایسے بزرگ کہاں ملیں گے۔اﷲ تعالیٰ انہیں مغفرت ورحمت کی نعمتوں سے سرفراز فرمائے۔ [جنوری۱۹۶۳ء]
Jesus of Nazareth is the central figure of the Christian religion, a savior believed to be both God incarnate and a human being. He is also known as Jesus Christ, the term “Christ” meaning anointed or chosen once. Most of the details of his life are unclear, and much of what is known about his life comes from the four Gospels of the Bible. The Gospels tell the story of Jesus’s auspicious birth in a stable in Bethlehem, and then of his life as an adult, a teacher with miraculous powers who foretold his own death to his closest followers, called apostles. Jesus, betrayed by the apostle Judas, was crucified by the Romans, and his resurrection three days after his death was taken as proof of his divinity. The date of Jesus’s birth to Mary is celebrated each December 25th as Christmas Day. The occasion was used as the base year for the modern Christian calendar, though researchers now believe that earlier estimates were inexact and that Jesus was actually born between 4 B.C. And 7 B.C. The date of the crucifixion is now marked as Good Friday, and the resurrection celebrated as Easter.
In the present work three series of Mannich bases of 1,3,4-oxadiazole-2(3H)-thione (121170) have been successfully synthesized with good to excellent yield and comprehensively characterized by FTIR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Furthermore, their in-Silico and in-vitro evaluation showed them as excellent urease inhibitors which were even better than standard. All the synthesized compounds were also evaluated for their antioxidant properties as well as antiviral activities against the four poultry viruses (IBA, H9N2 , NDV, and IBDV). The synthetic strategy for the synthesis of these Mannich base derivatives are as under. Synthesis and Biological evaluation of pyrazinyl based derivatives (119-135) The strategy for the synthesis of targeted compounds is elaborated in Scheme 29. Ethyl pyrazine-2-carboxylate (119) was prepared by the esterification of pyrazine-2-carboxylic acid (118), which was further converted into pyrazine-2-carbohydrazide (120) by refluxing with 80% hydrazine hydrate in ethanol. The synthesized hydrazide underwent cyclization to yield 5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione (121) upon reacting with CS2 in alkaline medium. Which was then further converted to respective Mannich bases 3-[{(substituted phenyl)amino}methyl]-5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione or 5-(pyrazin-2-yl)-3[{(substitutedpyridin-4-yl)amino}methyl]-1,3,4-oxadiazole-2-thione (122-135).