قاضی سلیمان صاحب منصور پوری
وہ مشرقی فاضل جس کی موت پر آج ہم کو ماتم کرنا ہے وہ قاضی محمد سلمان منصور پوری سابق جج پٹیالہ اور سیرت کی مشہور کتاب ’’رحمۃ للعالمین‘‘ کے مصنف ہیں، وہ علم و عمل، زہد و کمال اور فضل و ورع دونوں کے جامع تھے، روشن دل اور دماغ تھے، ان کے جدید و قدیم دونوں خیالات حداعتدال پر تھے، عربی زبان اور علوم دین کے مبصر عالم تھے، توراۃ و انجیل پر فاضلانہ و ناقدانہ نگاہ رکھتے تھے، غیرمسلموں سے مناظرہ کے شائق تھے، مگر ان کے مناظرہ کا طرز سنجیدگی، متانت اور عالمانہ وقار کے ساتھ تھا، مسلکاً اہل حدیث تھے، مگر اماموں اور مجتہدوں کی دل سے عزت اور ان کی محنتوں اور جانفشانیوں کی پوری قدر کرتے تھے۔
وہ ندوۃ العلماء کے دیرینہ رکن تھے اور اسی وساطت سے ان سے تعارف حاصل ہوا، اور تعارف نے باہم انس و مودّت کی صورت پیدا کی، جب مل جاتے دیر تک ہم ذوقی کا لطف قائم رہتا، سیرۃ، جدید مناظرات و کلام اور محاسن اسلام کے مختلف پہلوؤں پر گفتگو رہتی، اور اس لطف میں تھوڑی دیر کے لئے ہر چیز فراموش ہوجاتی، چند سال ہوئے کہ دارالمصنفین بھی ان کے فیض قدوم سے منور ہوا تھا، بلند قامت، خوش رو، خوش لباس، وجیہ، گھنی داڑھی، سپید صافہ باندھا کرتے تھے۔
ان کی مستقل تصنیفات میں رحمۃ للعالمین، الجمال والکمال (تفسیر سورۂ یوسف) اور سفرنامۂ حجاز، یادگار ہیں، ان کے علاوہ چھوٹے بڑے بیسوں رسائل ان کے قلم سے نکلے، مگر سب سے زیادہ ’’رحمۃ للعالمین‘‘ نے قبولیت حاصل کی، اسلامی مدرسوں میں داخل ہوئی، کورسوں میں شامل ہوئی، لوگوں نے ذوق و شوق سے پڑھا، خدا رحمۃ للعالمین کے مصنف کو اپنی رحمت عالم سے نوازے۔
سات آٹھ برس ہوئے کہ وہ ایک دفعہ...
This article is divided in to two sections: the first one; is to study of Ḥawāla according to Fiqhi rules, i.e. Its definition, conditions, its qualities and its specifications. In the second part, Ḥawāla is discussed according to application of the Bank, and its practical forms in different institutions. Ḥawāla is a contract in which a party or a person transfers his debt from his risk to another party or another person. Ḥawāla is used for different purposes, for example, bill of exchange, Financial Papers and different Banking accounts. This paper also discusses the difference between Ḥawāla and wakālah, Ḥawāla and Kafāla, and also Ḥawāla and Debt. Therefore, analysis, about Ḥawāla is very essential and many studies have been done on it. Furthermore, it will also critically provide their textual evidence and rational arguments in order to reach a financial juristic judgment. Ḥawāla is used in credit card, discounting of bill of exchange, etc. At the end the paper discusses its conclusion and offers some requests and suggestions.
Breast cancer is the second leading cause of cancer-related mortalities among females worldwide. It is genetically heterogeneous disease caused by various environmental and genetic factors. Abnormal expression of various genes/proteins such as chemokine C-X-C motif (receptor 4), insulin like growth factor-1 receptor and estrogen growth factor receptor and their associated biological regulatory networks are linked with breast cancer. In this study, the crosstalk interaction between these genes/proteins and their associated signaling networks involved in breast cancer metastasis were studied by using both in-silico (qualitative modeling, hybrid PetriNet modeling, pharmacophore modeling and virtual screening) and in-vitro approaches (genotyping, cell viability assay, quantitative real time polymerase chain reaction and western blotting). The association of rs1801157 single nucleotide polymorphism, located within the C-X-C motif ligand 12 (CXCL12) gene, with the development of breast cancer was assessed. The results of genotyping showed the significant prevalence of genotype GG (p<0.05) with a number of variables including patient’s age, weight, lymph nodes status, hormonal imbalances (ER and PR) and family history using multivariable logistic regression among Pakistani breast cancer patients as compared to AA genotype. Our in-silico results suggested that rs1801157 single nucleotide polymorphism identified in CXCL12 gene has crosstalk link with insulin like growth factor-1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) signaling and is an important factor in predicting the outcomes of breast cancer therapy, which can also result in multidrug resistance due to induction of insulin like growth factor-1. Furthermore, to address the problem of multidrug resistance in breast cancer cells, an effective and non-toxic biologically synthesized silver nanoparticles (drug delivery vehicles) were conjugated with anti-cancer inhibitors such as fulvestrant and gefitinib to inhibit the activity of multiple genes and proteins such as estrogen growth factor receptor, C-X-C motif (ligand 12), phosphoinositide 3 kinase, insulin receptor substrate-1, insulin like growth factor-1 receptor, PDZ domain containing 1 and estrogen receptor-α to treat breast cancer cells. In conclusion, for a multifactorial disease like breast cancer, more than one therapeutic targets should be inhibited with an effective drug delivery vehicle to induce apoptosis in cancer cells.