Achieving Educational Effectiveness Using Ict Tools in the Development of Competence in the Design and Modeling of Clothing in the Organization of Specialized Disciplines

This article discusses the implementation of information and communication technologies in the field of vocational education in the field of costume design, analysis of their use, training of teachers to improve the effectiveness of education using information and communication technologies. In this article discusses the development of students 'competence in designing and modeling clothing using modern information and communication technologies in the training of specialists, increasing students' knowledge and skills, interest in the learning process and the ability to apply their knowledge in practice in the future. The focus will be on developing appropriate strategies for the new education role. The data show that the use of information and communication technologies in the educational process helps to increase the effectiveness of education and facilitates the organization of the learning process. In particular, it shows that the contribution of information and communication technologies to the improvement of the educational process in educational institutions, where information and communication technologies are an innovative factor. Achieving this high level means that the educational institution must not only modernize the technological tools, but also change the teaching models.

Antimicrobial, Antioxidant and Protective Efficacy of Flower and Leaf Extracts of Calotropis Procera Against Free Radical Damage

Different soluble fractions viz., hexane, ethyl acetate, butanol and ethanol of Calotropis procera (Ait.) R. Br. were screened for their antimicrobial properties by using agar-well diffusion method against the human pathogens viz., Escherichia coli and Salmonella typhi (Gram negative), methcillin resistant Staphylococcus aureus and Micrococcus luteus (Gram positive), in vitro antioxidant properties were analyzed by means of DPPH free radical scavenging method, reducing ability assay and lipid peroxidation inhibition method. Furthermore, in vivo protective efficacy of C. procera extract against (NSAID) ibuprofen-induced nephrotoxicity in rat model was also determined by evaluating renal function markers, plasma measure of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) along with the determination of tissue lipid peroxidation markers, i.e. aldehyde products malonyldialdehyde (MDA) and 4- hydroxy-nonenal (4-HNE). Phytochemical analysis was also carried out for the detection of phenolic constituents, amino acids, protein, carbohydrates, reducing and non-reducing sugars in test plant. In the present findings the hexane fraction of C. procera flower and leaf have been proved very significant with maximum zones of inhibition i.e., flower (22mm) and leaf (23mm) against M. luteus. While, other tested fractions of C. procera flower and leaf showed significant antimicrobial activity against all pathogens. Whereas, in the present finding it was also determined that the flower ethanol extract showed the highest DPPH free radical scavenging activity (88.19% with 8 mg/ml) as compared to BHA which showed 85% scavenging activity as standard. Similarly, C. procera flower and leaf extracts were also analyzed for reducing capacity. The highest absorbance (i.e., 1.827 with 10mg/ml) was recorded in C. procera flower water extract as compared to standard which showed (0.238) absorbance. In vitro lipid peroxidation inhibition, another model was used to check the antioxidant capacity of C. procera. Flower water extract exhibited a concentration dependent increase in lipid peroxidation inhibition, the highest value is (89.58% with 10mg/ml) while the lipid peroxidation value in C. procera leaf water extract (i.e., 75.11% with 10mg/ml) and leaf ethyl acetate extract showed (75.11% with 8mg/ml). While, BHA (85%) and ascorbic acid (75.5%) showed lower values as compared to tested plant. However, body weight loss was successfully restored by the coadministration of Ibuprofen with C. procera hexane extract. While, increased level of renal function markers (urea, creatinine) was normalized by the administration of C. procera hexane with ibuprofen treatment. The imbalance in oxidative status was determined by evaluating decreased level of catalase, superoxide dismutase and glutathione along with increased levels of malonyldialdehyde and 4- hydroxynonenal, which was counteracted by the co-administration of C. procera hexane extract with ibuprofen which maintained cell sustainability and indicated nephro-protective activity of C. procera. Besides the above results C. procera leaf and flower aqueous extract were also used to check enzymatic activities of glucoamylase, α-amylase and urease enzymes. The flower extract is found proved to be a good enhancer of glucoamylase, α-amylase and urease activity as compared to leaf extract. A number of phytoconstituents were also detected. The presence of phytochemicals in C. procera may indicate a good correlation with that of antibacterial, antioxidant potential and protective role for in vivo model which also proved as a good enhancer of enzyme activities. Thus due to aforementioned activities, Calotropis procera may serve as a better and a protective therapeutic agent than any other synthetic drug.