تاريخية السنة بين المثبتين والنافين

A group of contemporary rationalists have repeatedly maintained that the rulings derived from the Sunnah have a historical framework that does not transcend them. After being proved, they must remain locked in the time in which they were said, and we are not obliged to follow them. The prophetic interpretation of the Qur'anic text is not the only interpretation, Is one possible form of interpretation. The rationalists market some evidence of this, including: copies, reasons for descent and causes of roses, and the language of some Koranic verses. In this research we will discuss the issue of this issue, and the statements of the parties and their evidence.

Synthesis of Nucleobase-Functionalized b-Tripeptide Scaffolds for Higher Ordered Molecular Architectures

The stability of cyclic peptides and their self-assembling ability is an important aspect in the DNA recognition studies. Functionalization of cyclic peptides with nuclear bases may serve the purpose of mimicking and interacting with the DNA single strand. Stacking of the cyclic peptides after functionalzation may develop steric hinderance. L-Lysine, with side chain amino group, was selected to avoid these steric factors. Differently-protected L-lysine was transformed into its respective β-analogue using Arndt Eistert synthesis. These β-amino acids were utilized to synthesize cyclic β-tripeptide scaffolds through a multistep sequence. The scaffolds after deprotection were subjected to functionalization with the selected nuclear bases (adenine, thymine, cytosine and guanine) after conversion to their acetic acid derivatives. The nucleobase-functionalized cyclic β-tripeptide scaffolds were completely deprotected, purified by RP-HPLC and characterized by ESI and HRMS.