مڈھلی گل
میرا تعلق اوس خوش قسمت پیڑھی نال اے جس دادی، نانی، ماسی تے پھپھی تے رشتیاں دا موہ رج کے مانیا۔ گھر وچ دادی یاں نانی کولوں روز کہانی سننی تے جے کر ایہناں رشتیاں آنا ہوندا تاں چاء چڑھ جانا۔ جدوں ایہناں دے پرتن دا سماں آنا تاں کدے ایہناں دی جتی لکو دینی تے کدے کپڑیاں والی گٹھڑی۔ جے انج نہ کرنا تاں رو رو کے برا حال کر لینا۔ وقتی طور تے اوہناں نے اپنا پروگرام اگے پاء دینا تے رات نوں مڑ کہانی سنن دا موقع مل جانا۔ اگلی سویر ایہناں ستے ہوئے چھڈ کے ٹر جانا۔ کدے کدے ایہناں کولوں دن سمے وچ کہانی سناون دی منگ کرنی تاں اگوں جواب کجھ انج دا ملنا:
اوئے کھوتیا! بھلا کوئی دن نوں وی کہانی سندا اے۔ دن ویلے کہانی سنئے تاں بندہ رستہ بھل جاندا اے۔
فیر حیاتی دے پنچھی نے اجہی اڈاری ماری کہ ایہہ رشتے آلوپ کیہ ہوئے کہانیاں وی لک گئیاں تے ہن جدوں اوہ رشتے تے کہانیاں یاد آندیاں نیں تاں من وچوں اک ہوک نکل دی اے۔
میں ایس گلوں اپنے آپ نوں بہوں خوش قسمت سمجھدا ہاں کہ مینوں سروس دے دوران اجہے طالب علم ملے جنہاں لوک کہانیاں اکٹھیاں کرن وچ میری رج کے مدد کیتی۔ میں کئی وار اوہناں دے بزرگاں نوں ملن اوہناں دے گھریں گیا تے ایہہ کہانیاں لکھیاں جو ہن تہاڈی سیوہ وچ کتابی روپ وچ پیش کر رہیا آں۔ پڑھو شاید تہانوں وی کسے رشتے دی یا د آ جاوے۔ جے انج ہو جاوے تاں اوس دی بخشش لئی دُعا ضرور کرنا۔
کہانیاں نوں سو دھن تے ترتیب دیون وچ بہتا ہتھ میرے گھر والی پروفیسر صفیہ ایوب ہوراں دا اے۔ میں اوہناں...
Aims of Study: The purpose of this study is to ascertain the impact of positional release technique and muscular energy technique on low back pain.
Methodology: It was a single blinded randomized controlled trial. Participants were enrolled using envelop method of simple random sampling technique. A total n=30 clinically diagnosed LBP patients with between 26 to 40 y/o were recruited and randomly divided into two groups. Group-A MET (n=15) patients receiving muscle energy technique and Group-B PRT (n=15) patients receiving Positional Release Technique for two weeks.
Results: Between groups analysis was performed using independent t test as the data was normally distributed. The results revealed statically significant results in both the groups. However, group A show more significant results with mean value of 2.0±0.53, 10.73±1.79, and 2.80±0.14 for NPRS, ODI, and Modified Schober’s Test Score respectively as shown in table 3.
Limitations and Future Implications: The study may have had a limited number of participants, which could affect the generalizability of the results. Secondly, the study might have focused on short-term outcomes, assessing the immediate effects of the interventions.
Originality: The study has used and compared new technique and have identified the efficacy between the two physical therapy intervention based study.
Conclusions
According to the findings of this study, both therapy options are successful in treating low back pain. The effectiveness of the patients in the muscle energy technique group, however, showed a substantial difference.
Ketoprofen granules were prepared by a relatively newer method, namely surfactant assisted wet granulation (SAWG) approach using different concentrations (1-5%) of Soluplus®, polyethylene glycol (PEG) 6000, PEG 4000, poloxamers L6200 and L3100. The developed granule formulations were characterized for physicochemical and dissolution characteristics. FTIR examined for any drug-excipients interactions. Granule size, percent yield, bulk and tap density, Hausner’s ratio, and angle of repose of granules were found to be 571 ±0.81 µm, 93.1 ±0.84 %, 0.223 ± 0.01g/ml, 0.231 ± 0.002 g/ml, 1.098 ± 0.005, 33.81 ± 0.23º, respectively. Granules with 1% Soluplus® revealed highest solubility (3.09 mg/ml), but with 58.3% ketoprofen release until 12 h. Granules containing 5% PEG-6K demonstrated improved solubility of ketoprofen as compared to pure drug, i.e. 2.81 mg/ml vs 0.010 mg/ml. This increase in solubility was observed to be due to micellar solubilization, complex formation, or hydrogen bonding, which was supported by FTIR. All the formulations exhibited release comparable to that of USP-stipulated sustained release pattern following Weibull model (β=1.08) and showing erosion-controlled release. FTIR indicated no chemical interaction between ketoprofen and excipient in granule formulation. The SAWG successfully ameliorated ketoprofen solubility and sustained its release as well. To develop the single unit dose to achieve the better bioavailability of sustained release ketoprofen granules, matrix tablets were prepared using the defined concentration, i.e., 1%, 3% and 5% of Soluplus®, PEG-6K, PEG-4K, L6200 and L3100. The prepared ketoprofen tablets were characterized for physicochemical, in vitro dissolution, FTIR and in-vivo (human pharmacokinetic study) parameters. FTIR studies were carried out to ensure any possible ii interactions among active and other excipients. Friability, thickness, hardness, weight variation, drug content and swelling index were found to be 0.14%, 4.77mm, 7.5 kgcm-1, 401mg, 99.95% and 29.38% respectively. In-vitro dissolution revealed 60-102% release till 8h. MT2, MT13 depicted the ideal sustained release pattern till 8h, i.e., > 80% which was fitted to Weibull release model with ß value 2.57 and 1.06 respectively, indicating the complex release mechanism. FTIR evident the compatibilities of drug-excipient during compression. A tablet formulation with similar profile to that of the sustained release, MT2 was selected for pharmacokinetic study. MT16 was also selected as a control for PK parameters evaluation. MT16 promptly attained the plasma peak within 1h after administration and followed a rapid exponential decrease till 12h. MT2 as a sustained release tablet showed delayed peak plasma concentration which was maintained above 0.7-1.0 µg.ml 1 till 24h with a gradual decline. The maximum plasma concentration (Cmax) resulting from administration of 200 mg of MT2 was statistically lower than that of the MT16 (5.19 ± 0.66 vs 9.62±0.76 µg.ml-1, P<0.05). The time to reach Cmax (Tmax) from MT2 was delayed to 5.56±0.30 h as compared to 1.15±0.11 h of MT16. The AUC0-∞, 78.65±7.64 µg.h.ml-1, of MT2 was higher than 34.39±3.06 µg.h.ml-1 of MT16. Considering MT2 as Test and MT16 as Reference formulation, the relative bioavailability was found to be 228.89±12.578%. Clearance of drug was observed to be declined for MT2 compared to MT16 (5.855±0.539 to 2.561±0.235 L/h), a reason for sustaining drug concentration in blood beyond 24 h instead of 12 h for MT16. The delayed Tmax, decreased Cmax, increased AUC and decreased ClT, MT2 exhibited an in-vivo behavior corresponding to the sustained drug delivery system. MT2 sustained release matrix tablets depicted the therapeutic ketoprofen plasma level effectively even beyond 24h. Thus, there is a likelihood of administration of once-a-day single dose without plasma fluctuations which were expected from the administration of two doses in a day of MT16. The in-vitro characteristics, i.e., the dissolution of MT2 were predictive of the iii in-vivo profile of the drug. The IVIVC evaluation indicated a good correlation for the drug releases in-vitro and absorbed in-vivo at predicated time intervals. The SAWG successfully helped developing the swellable-erodible sustained release matrix tablet formulation of ketoprofen with desired in-vitro, biopharmaceutical and pharmacokinetics properties without incorporation of any special ingredients or major manipulation of the formulation ingredients. The desired features in the present dosage form were accomplished just by surfactant-assisted granulation, thus SAWG was regarded as the simpler approach.