استفہام بمعنی امر
بسااوقات استفہام امر کے معنوں میں استعمال ہوتا ہے ۔ ذیل کی آیت:
"إِنَّمَا يُرِيدُ الشَّيْطَانُ أَنْ يُوقِعَ بَيْنَكُمُ الْعَدَاوَةَ وَالْبَغْضَاءَ فِي الْخَمْرِ وَالْمَيْسِرِ وَيَصُدَّكُمْ عَنْ ذِكْرِ اللَّهِ وَعَنِ الصَّلَاةِ فَهَلْ أَنْتُمْ مُنْتَهُونَ"۔ [[1]]
"شیطان تو یہی چاہتا ہے کہ شراب اور جوئے کے ذریعے تمہارے درمیان دشمنی اور بغض کے بیج ڈال دے اور تمہیں اللہ کی یاد اور نماز سے روک دے ، اب بتاؤ کہ کیا تم ان چیزوں سے باز آ جاؤ گے"۔
اس آیت میں ’’فھل انتم منتھون ‘‘ در اصل ’’انتھوا عنھا‘‘ کے معنی میں مستعمل ہے ۔
"فَإِلَّمْ يَسْتَجِيبُوا لَكُمْ فَاعْلَمُوا أَنَّمَا أُنْزِلَ بِعِلْمِ اللَّهِ وَأَنْ لَا إِلَهَ إِلَّا هُوَ فَهَلْ أَنْتُمْ مُسْلِمُونَ"۔[[2]]
"اس کے بعد اگر یہ تمہاری بات قبول نہ کریں تو (اے لوگو) یقین کر لو کہ یہ وحی صرف اللہ کےحکم سے اتری ہےاور یہ کہ اللہ کے سوا کوئی عبادت کے لائق نہیں، تو کیا اب تم فرما بردار بنو گے"۔
جناب فلاحی کی رائے میں آیت مذکور میں ’’فھل انتم مسلمون‘‘ استفہام کے معنی میں نہیں بلکہ امر کے مفہوم میں استعمال ہوا ہے یعنی ’’اسلموا لھذا لاکتاب و آمنو ‘‘ ۔[[3]]
" قُلْ أَرَأَيْتُمْ إِنْ أَهْلَكَنِيَ اللَّهُ وَمَنْ مَعِيَ أَوْ رَحِمَنَا”[[4]]
"اے پیغمبر ان سے کہو کہ ذرا یہ بتلاؤ کہ چاہے اللہ مجھے اور میرے ساتھیوں کو ہلاک کر دے یا ہم پر رحم فرما دے"۔
قاضی ثناء اللہ پانی پتی کے مطابق ’’ارءیتم‘‘ میں ابتدائی ہمزہ استفہام تقریری کے لیے...
A qualitative phenomenological approach was used in this study to describe the lived experiences of Tagumpay National High School (TNHS) teachers on Online Learning Action Cell (LAC) session. LAC is a school-based professional development for teachers implemented by the Philippine Department of Education (DepEd). Due to teacher’s lack of participation on classroom LAC, a fully-online mode option is explored by offering TNHS teachers Online LAC session using Facebook as a Learning Management System (LMS). To capture the lived experience of teachers, an in-depth interview with a purposive sample of one TNHS teacher is done in the process. The data gathered went through “Hycner’s Explicitation Process” (1999, in Groenewald, 2004) which includes bracketing, delineating, clustering, summarizing and extracting unique themes. Validity and Credibility were accomplished through an intercoder agreement between researchers, Facebook chat records, bracketing, and member checking. Results identified three themes in relation to teacher’s experience of Online LAC session including usefulness, barriers, and preference. Findings revealed the major role of TNHS teacher’s context on how Online LAC is utilized. Recommendations include administrator and expert teacher working with classroom teachers and the inclusion of teachers’ voices as input in the program design, implementation and evaluation stages of Online LAC to better address curriculum needs and facilitate the delivery of high-quality professional development for teachers’ professional growth.
Transdermal Drug Delivery Systems (TDDS) exists for a long time such as creams, and ointments for topical ailments.Incorporating drugs in transdermal patch ismore recent application. Liquid reservoir system, solid reservoir/peripheral adhesive system or matrix (drug in adhesive) system may be used to deliver the drug through skin. In present work thirty six matrix type transdermal patch formulations of diclofenac sodium, diclofenac potassium, diclofenac diethylamine and flurbiprofen (nine each) were developed by using hydroxypropylmethylcellulose (HPMC 4000 cps,), polyvinylpyrolidine (PVP K-30,) and ammonio methacrylate copolymer type A (Eudragit RL-100). Different skin permeation enhancers like isopropyl myristate, isopropyl palmitate and tween 80 were incorporated in the formulations. The influence of various formulation variables, such as initial drug load and certain skin permeation enhancers on permeation characteristics of selected analgesics from the prepared formulations was studies through hairless abdominal rabbit skin by using the modified Franz diffusion cell. The permeation parameters were estimated by Chow method following the Fick’s law of diffusion. The penetration profiles of all formulations were influenced significantly (p <0.05) by the addition of enhancers in comparison to formulation controls (without enhancers) and commercially available product (market control). Among the enhancers studied, isopropyl myristate and isopropyl palmitate produced better results with high relative permeation ratio (14.61, 27.40) and enhancing factor (32, 7.83). All the formulations showed good stability and reproducibility. The prepared patch formulations resulted better permeability as compared to the controls with high apparent permeation rates (121.18 ± 34.37 µg.h-1 cm-2) and diffusion coefficients (8.68 ± 0.43 cm2/s × 10-4) with shorter lag times (1.0 ± 0.15 h). The diffusion coefficients were found independent of initial drug load for all formulations. Release profiles were evaluated by model-dependent approaches. The drug release from almost all formulations was best explained by zero order equation, as the plots showed highest linearity (r2 > 0.952), followed by Higuchi equation. The mechanism of drug release for most of formulations was super case II transport and in few, non-Fickian diffusion. The pharmacokinetic parameters of optimized formulations for each drug were determined from blood levels which revealed a profile typical of sustained release formulation having low elimination rate constants and high Mean Residence Time with the ability to maintain adequate plasma levels for 24 h i.e. up to the next application. The higher steady-state flux, diffusion coefficient and permeability coefficient, as well as the decreased lag time of permeation ofdiclofenac sodium 5% with IPP, 5% diclofenac potassium with IPM, 5% diclofenac diethylamine with IPP and flurbiprofen 10% with IPM as compared to formulation control (without enhancer) and commercially available gel (market control) was obtained. The faster permeation of the drug as compared to the controls could be attributed to the incorporation of skin penetration enhancer. The pharmacokinetic analysis confirmed that the optimized formulations exhibit typical sustained release phenomenon having low elimination rate constants and high MRT with the ability to maintain adequate plasma levels for 24 h i.e. up to the next application. Therefore it is concluded that the incorporation of skin penetration enhancers like IPM and IPP are promising in developing matrix type patch formulation.