Youth Empowerment for the Development and Defense of Madina State

Youth Empowerment has always been an icon of progressive process where young people are encouraged to peep into their future. It is not limited to develop individuals rather to formulate a great community change which rely on the development of individual capacity. Having dazzling achievements on its dimensions, the evolution of Islam flourished due to the youth’s inspiring role for the cognitive development in every sphere of life. The Holy Prophet (ﷺ) explored his young companions’ access to their resources, then transformed their consciousness, intellect and ensured their empowerment to promote traditional, moral and theological values. Its aim has always been to improve one’s quality of life in social, economic, socio-political and even war fares as well. Enhance to companions young his empowered (صلى الله عليه وسلم) Prophet Holy The their belief in self-efficacy in various territories. They battled against their contemporary challenges to meet positive sense of self-control, decision making skills, moral system of beliefs and pro-social connectedness. All these have numerous instances for their substantiations. The present research paper will substantiate the young companions’ pivotal efforts in the early age of Madīnah city to promote Islamic norms, their key role in battles, compilation of Qur’ān and Ḥadīth and various other significant defensive roles performed by the youth of that era after given powers by that highlight also will paper research present The. (صلى الله عليه وسلم) Prophet Holy the how the youth of today can empower itself to utilize their perceptive. (صلى الله عليه وسلم) Prophet Holy of companions young by archives set the from app

Screening of Phytochemicals Against Cysteinyl Leukotriene Receptor 1 Through Molecular Docking

Asthma is one of the most frequent disorders being observed in clinical practices. Cysteinyl leukotrienes (CysLTs) are the main mediators of the entire allergic reactions and also a vital part of the inflammatory reactions that lead to the usual symptoms of asthma. Montelukast and Zafirlukast are known leukotriene receptor antagonists prescribed in asthma treatment. However, these fall short as mono therapy and are frequently used in combination with inhaled glucocorticosteroids with or without long acting beta 2 agonists. Therefore, it is of interest to apply ligand and structure based virtual screening strategies to identify compounds better than lead compounds i.e., Montelukast and Zafirlukast. The aim of the present study was to identify the novel phytochemicals of anti-asthma plants against cysteinyl leukotriene receptor 1, which had more antagonizing potential as compared to Montelukast and Zafirlukast and could be helpful to control the asthma disease. For this purpose, 1216 phytochemicals of 54 medicinal plants against cysteinyl leukotriene receptor 1 were screened. Montelukast and Zafirlukast were selected as lead compounds. Phytochemicals were retrieved from NCBI?s PubChem database and grouped and docked at the antagonist binding site of cysteinyl leukotriene receptor 1. Results showed that five phytochemicals (Phytic acid, Heptacosanol, Triacontane, Nonacosan-15-one, n- hentriacontanol of plants solanum nigrum, tinospora cordifolia, pipper betel linn, tinospora cordifolia and vitex negundo respectively) had higher predicted binding as compared to Zafirlukast and Montelukast. However, among five identified phytochemicals, the phytic acid showed highest appreciable S score. Results of this study may be used in computer aided screening of the drugs against asthma disease.