اقتدار اور اسیری
ذوالفقار علی بھٹو شہید نے صرف چار سال اور بیس دن سیاست جبکہ پانچ سال ،چھ ماہ اور پندرہ دن حکومت کی جس کے بعد پھانسی کی سزا ہوئی ۔تحریک ،قتدار اور اسیری کا یہ کل دورانیہ بارہ سال اور پانچ دن ہے ۔نواز شریف کو سیاست میں تیس برس گزر چکے ہیں ۔مولانا فضل الرحمن کو سینتیسواں سال ہے اور عمران نیازی کو بائیس سال ۔
ذوالفقار علی بھٹو شہید کو پھانسی دینے والے ڈکٹیٹر کو بھی قتدار کے گیارہ سال ایک ماہ اور بارہ دن ملے مگر ان میں سے کوئی بھی ذوالفقار علی بھٹو شہید کا متبادل نہ بن سکا ۔اب یہ بھٹو کا کرشمہ ہے یا بھرپور طاقت اور وقت ملنے کے باوجود متبادل بننے کی کوشش کرنے والے لیڈروں کی نااہلی کہ بھٹو زندہ ہے ۔
دنیا کی تاریخ میں بہت کم ایسے لیڈر ہیں جنہوں نے اتنے گہرے اثرات مرتب کیے ہیں ۔ایسا صرف مذہبی تحریکوں میں ممکن ہوا ہے یا بھٹو نے ممکن کر دکھایا ہے ۔بھٹو ضدی تھا ۔اسے جب تک تسلیم نہیں کیا جائے گا اور وہ اپنی جنگ جیت یگا ۔کہیں لکھ کر رکھ لیں وہ مرنے والا نہیں ۔ذوالفقار علی بھٹو شہید نے کہا تھا کہ آخری قہقہہ عوام کا ہو گا ۔
مجھے لگتا ہے کہ پاکستان کے عوام ادھر وہ قہقہہ لگائیں گے اور ادھر بھٹو آنکھ مار کر مر جائے گا ۔ذوالفقار علی بھٹو شہید صرف پاکستان پیپلز پارٹی کی پراپرٹی نہیں ہے بلکہ یہ پاکستان کی پراپرٹی بھی ہے ۔وہ ہمارا منتخب وزیر اعظم تھا ۔ہمیں دوسرے خطوں سے ہیروز امپورٹ کر نے پڑتے ہیں ۔بھٹو ہمار ا وہ مقامی ہیرو ہے جسے ہم دنیا میں ایکسپورٹ کرتے ہیں ۔
اٹل بہارئی واجپائی بھی...
Background: Non-atherosclerotic processes are regarded as equally important contributors to a substantial number of coronary problems mainly myocardial infarction. This includes coronary spasm which has been considered as one of the coronary syndromes leading to myocardial infarction. These non-atherosclerotic events ensuing in major averse cardiac events (MACE) not only require various diagnostic and therapeutic strategies but also there is a need to delineate the underlying etiology for their effective treatment and management. Case Summary: We report a case of anterior wall myocardial infarction (AWMI) driven by a non-atherosclerotic event i.e. Coronary spasm. Concomitant marked ST-segment elevation recorded on ECG revealed a diffuse mid distal disease in our patient. We report here the initial presentation, coronary care & intervention and throughout the clinical course of our patient. Conclusion: Myocardial infarctionsinvolving non-atherosclerotic causes in young individuals as in our study should be reported by medical practitioners and given equal importance as they might indicate the underlying root cause of such events. Effective treatment of such future cases can be done by taking management strategies, diagnostic findings and prognostic data into consideration.
Among viral hepatitis, HCV is the second leading cause of hepatitis with approximately 3% carriers worldwide and 8-10 % carriers among Pakistani population. In the absence of any approved vaccine against HCV, the pegylated- interferon-alpha in combination with Ribavirin is the only standard regimen. The goal of this treatment is viral eradication to achieve sustained viral response (SVR) which means to decrease the viral titer to undetectable levels after treatment completion. However, the success rate is not hundred percent for this treatment (40- 50% for HCV genotype 1/ 4 and 75-80% for HCV genotype 2/3). Beside this fact, this treatment has several side effects that require either treatment modification or withdrawal. The present study was designed to find out the association of viral and host factors with the response of interferon treatment in chronic HCV patients of Pakistan. Two hundred CHC treatment-naïve patients from June 2011 to June 2013 were enrolled and treated with combination therapy of interferon plus ribavirin. Treatment response was analyzed by quantifying viral titer at specific interval of times during the treatment course and 6 months after treatment completion. Response rate was as followed; 81.1% patients attained Sustained virologic Response (SVR), 11.7% patients did not respond and in 7.2% patients’ virus was relapsed. It was observed that HCV genotype 3a is the most prevalent genotype followed by 1a while prevalence of mixed genotype is the least in Pakistan. Moreover, the success rate of treatment is higher in patients infected with HCV genotype 3a as compared to HCV genotype 1a. Quantification of viral load at 3rd month of treatment is valuable determinant of SVR and also helpful in tailoring the individualize treatment. As the SVR rate (93.3%) is higher in patients who achieved early viral response (EVR) as compared to those who failed to attain EVR (6.7%). It was observed that the success rate in female patients is more than male patients while rate of non-response is more in male patients than female. While no association of SVR with body mass index and age of patient was analyzed. Human genetic variations of IL28B SNPs (rs12979860, rs12980275, rs8099917, rs1181222) was identified and find out that the patients with CC genotype of SNP rs12979860 of IL28B are more likely to cure than patients with CT/TT genotype of SNP rs12979860. While the rate of NVR and relapse is higher in patients having GG genotype of SNP rs8099917. The results of multivariate logistic regression showed significant association of following factors with SVR; female gender (OR; 5.99, 95% C.I; 1.26-28.51, p= 0.024), HCV genotype 3a (OR; 9.33, 95% C.I; 1.94-44.95, p=0.005), 12 week response EVR (OR; 14.83, 95% C.I; 2.87-76.7, p=0.001) and CC genotype of SNP rs12979860 (OR; 6.39, 95% C.I; 1.18-34.7, p=0.032).